Navigation Links
Urine protein may be present before hypertension diagnosis in at-risk adolescents
Date:2/27/2008

A protein that is an early indicator of kidney dysfunction in adults may predict hypertension in black adolescents, Medical College of Georgia researchers have found.

Microalbuminuria, excessive amounts of albumin in the urine, is a common problem among diabetics, says Dr. Gregory Harshfield, director of the Medical College of Georgias Georgia Prevention Institute. For that reason, the few studies that have looked at adolescent patients have been focused on sick populations and even fewer have examined the phenomenon in healthy adolescents. What we were looking to find was the prevalence of the problem in a healthy population of children and adolescents and the impact of race, sex, sodium-handling and blood pressure on microalbuminuria.

Dr. Harshfield and his co-investigators, Dr. Coral Hanevold, a former MCG pediatric nephrologist now at the University of Washington in Seattle, and Dr. Jennifer Pollock, an MCG pharmacologist, studied 317 healthy teens age 15-18. The results are published in the February issue of Hypertension, a journal of the American Heart Association.

The subjects were place on a three-day sodium-controlled diet prior to testing on day four. Testing consisted of a two-hour baseline period, a one-hour stress period and a two-hour post-stress period. Urine samples were obtained at the end of each hour. Levels of microalbumin were determined following the first-hour baseline period.

Researchers found that the black teens had a 10 percent higher rate of albumin in their urine than their white counterparts, despite the fact that both groups had normal blood pressure. Those results suggest that kidney damage in these high-risk youths is apparent even before the development of high blood pressure. The black girls had a 22 percent higher albumin excretion rate than white girls.

The higher levels correspond to a tendency to retain sodium after stress, Dr. Harshfield says, noting that sodium retention is normal during stress but should normalize after the stressor has passed.

What weve shown is that children and adolescents, particularly black children, can display reduced kidney function prior to the onset of hypertension. Therefore, it would be prudent to measure levels of microalbuminuria in high-risk patients.


'/>"/>

Contact: Jennifer Hilliard
jhilliard@mcg.edu
706-721-8604
Medical College of Georgia
Source:Eurekalert  

Related medicine news :

1. Urine Test Results Can Point to Heart Dangers
2. Contamination from depleted uranium found in urine 20 years later
3. Human Urine Safe, Productive Fertilizer
4. VBI, Mayo Clinic investigate link between fungal proteins, innate immunity and asthma
5. Researchers identify and shut down protein that fuels ovarian cancer
6. Out-of-whack protein may boost Parkinsons
7. Scientists identify proteins that help bacteria put up a fight
8. Protein shines light on cancer response
9. 3 newly discovered ERK pathway proteins related to CagA induced disease
10. U of M researchers determine structure of protein that mutates DNA of the AIDS virus HIV-1
11. Oncoproteins double-team and destroy vital tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Urine protein may be present before hypertension diagnosis in at-risk adolescents
(Date:8/18/2017)... ... August 18, 2017 , ... The Dawn Johnson Insurance Group, ... new charity drive to generate community support for efforts to educate the local population ... treatments for all types of cancer. , Each day in America, roughly 4,600 ...
(Date:8/18/2017)... ... August 18, 2017 , ... Radabaugh & ... assistance to communities in North-Central West Virginia, is embarking on a cooperative charity ... in the area. , The Chestnut Mountain Ranch (CMR) is a Christ-centered boarding ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... planning assistance that serves communities throughout southern Florida, is working to support the ... assets to children from low income families. , The Take Stock In Children ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... and financial planning firm that serves residential and commercial clients in the greater ... drive to raise community support for the fight against cancer. , Founded by ...
(Date:8/18/2017)... Louis, Missouri (PRWEB) , ... August 18, 2017 , ... ... says Suzanne Tucker, Founder of St. Louis-based positive education company Generation Mindful. To help ... they help children learn social and emotional skills, she created the Time-In Toolkit, which ...
Breaking Medicine News(10 mins):
(Date:8/11/2017)... , Aug. 11, 2017 DarioHealth Corp. (NASDAQ: ... health and big data solutions, today announced that it ... August 14 and host a conference call at 9:00am ... operating and financial results and its strategy and outlook ... hosted by Erez Raphael , Chief Executive Officer, ...
(Date:8/7/2017)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... Board of Directors has approved the payment of a quarterly ... The cash dividend of ... 27, 2017 to stockholders of record as of the close ... are subject to approval of the Board of Directors and ...
(Date:8/4/2017)... -- Agragen, LLC, a Cincinnati -based ... and aquacultural feed sectors, announces a significant step ... AGR131.  This drug is designed to trap and ... patients suffering from inflammatory conditions such as rheumatoid ... Biological pharmaceuticals currently used ...
Breaking Medicine Technology: