Navigation Links
Urine Test for Heart Disease Shows Promise
Date:4/29/2009

Noninvasive method detects dangerous levels of artery-blocking proteins

WEDNESDAY, April 29 (HealthDay News) -- A urine test to detect coronary artery disease has worked well in a small trial, German researchers report.

The test looks for fragments of the protein collagen, which plays a major role in blocking heart arteries, said study author Dr. Constantin von zur Muehlen, a fellow in cardiology at University Hospital Freiberg. He was scheduled to report the findings Wednesday at an American Heart Association meeting in Washington, D.C.

"Collagen forms a fibrous cap on the epithelium, the lining of the arteries," Muehlen explained. "These fibrous caps produce collagen fragments."

High concentrations of those fragments, called proteomes, in urine can signal atherosclerosis (hardening of the arteries), which can lead to a heart attack, Muehlen said.

The urine test was done for 67 people with symptoms of coronary artery disease, he said. Two techniques to detect proteins, mass spectrometry and capillary electrophoresis, were used to find levels of 17 protein fragments that the researchers had identified as being associated with atherosclerosis.

When the results were compared to coronary angiography, an X-ray exam that is a standard method for diagnosing atherosclerosis, the urine tests were found to be 84 percent accurate, Muehlen said.

But a urine test to detect heart disease will not be developed quickly, he said. The German researchers have gone back to the laboratory, working with a strain of mice genetically engineered to develop coronary artery disease as they age.

"We went to this mouse model and found that, over time, the pattern of proteomes becomes more heavily expressed," Muehlen said. "The older the animal, the more extreme the pattern will be."

While he hopes to do a larger human study, no timetable for one has been set, Muehlen said.

More animal studies are needed to fill in knowledge gaps, he said. "We don't know if stable regions of atherosclerosis produce more collagen than unstable regions," Muehlen explained. Unstable collagen is more likely to rupture, blocking an artery completely.

This is not the first report of a urine test for coronary artery disease. In 2007, physicians at Brigham and Women's Hospital in Boston found that the presence of the protein albumin in urine of people with stable cardiovascular disease indicated an increased risk of death.

Albumin is normally found in blood, but not in urine. Leakage of albumin into the urine indicates damage to the blood vessels of the kidney, and so points to an increased risk of cardiovascular death, the researchers said.

The German study is "interesting, but I'd be cautious," said Dr. Alan Daugherty, director of the Cardiovascular Research Center at the University of Kentucky.

"In general, it obviously would be desirable to be able to diagnose coronary artery disease without an angiogram," Daugherty said. "There has been a tremendous amount of effort looking for biomarkers."

But a good deal of work is needed to move the results of the study toward clinical use, he said. "We've been trying to do something like this for decades," Daugherty noted.

More information

Learn about coronary artery disease from the U.S. National Heart, Lung, and Blood Institute.



SOURCES: Constantin von zur Muehlen, fellow, cardiology, University Hospital Freiberg, Germany; Alan Daugherty, M.D., director, Cardiovascular Research Center, University of Kentucky, Lexington; April 29, 2009, presentation, American Heart Association Arteriosclerosis, Thrombosis and Vascular Biology annual conference, Washington, D.C.


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Urine test may determine if a smoker is at risk for lung cancer
2. Urine Test Could Gauge Smokers Lung Cancer Risk
3. Urine Test May ID Unhealthy Diets
4. Breath or urine analysis may detect cancer, diabetes
5. Taurine: Key to the visual toxicity of an anti-epileptic drug for children?
6. Urine Test May One Day Predict Prostate Cancer
7. Super Prostate Product - More Beta-sitosterol, all-natural Best Prostate(TM) Formula for Enlarged Prostate and BPH - Increases Urine Flow, Reduces Waking and Improves Quality of Life
8. Urine protein may be present before hypertension diagnosis in at-risk adolescents
9. Urine Test Results Can Point to Heart Dangers
10. Contamination from depleted uranium found in urine 20 years later
11. Human Urine Safe, Productive Fertilizer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Urine Test for Heart Disease Shows Promise
(Date:3/24/2017)... , ... March 24, 2017 , ... ... for contaminated soil, dredged material, and hazardous and non-hazardous materials announced today the ... Pennsylvania. This acquisition will add four additional processing facilities and a vast ...
(Date:3/24/2017)... ... 2017 , ... Digital Scientists, a software innovation lab specializing in web design ... Greenville, South Carolina location. The lab has set up shop at the renowned ... with South Carolina clients for years from our office here in Atlanta,” explains Digital ...
(Date:3/24/2017)... ... 2017 , ... The iaedp Foundation, the premier provider of educational programs and ... from the full spectrum of disordered eating, announced today that the 2017 Symposium set ... 50 states and several countries converged on the Green Valley Resort in Las Vegas. ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... (ONS) wanted to create a communications platform that positions them as the go-to ... and ONS reinvented their online publication as an always-on, always-fresh news, views and ...
(Date:3/24/2017)... , ... March 24, 2017 , ... Viewers who like ... of critical historical facts, cultural practices, goods, services, and societal issues tend to appreciate ... look into the popular practice of utilizing running events for causes around the world. ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... --  Genprex, Inc. , a privately held, clinical-stage biopharmaceutical company developing ... Company,s Chief Operating Officer, is scheduled to present a corporate overview ... Annual Cancer BioPartnering & Investment Forum: Tuesday, March 28, 2017 at ... ... Annual Future Leaders in Biotech Industry – Friday, April 7, 2017 ...
(Date:3/24/2017)... and PUNE, India , March 24, 2017 ... estimated to reach $2,614 million by 2022, Globally, registering a CAGR of 5.1% from ... highest revenue, and is projected to dominate the market during the study period. ... ... Research Logo ...
(Date:3/24/2017)... Mar. 24, 2017 Research and Markets has announced ... Growth and Demand Forecast to 2022" report to their offering. ... The global wound care market ... at a CAGR of 6.7% during 2016-2022 Among the various ... largest share in the global market in 2015. Among the various applications, ...
Breaking Medicine Technology: