Navigation Links
Urine Markers May Reveal Kidney Damage Earlier
Date:11/12/2010

THURSDAY, Nov. 11 (HealthDay News) -- Researchers have pinpointed certain markers in urine that may indicate acute kidney injury (AKI), a finding they believe could lead to a simple urine test to diagnose AKI early and prevent kidney failure.

AKI usually doesn't show obvious physical symptoms, which is why researchers are eager to find other signs of disease.

The study found that urine samples from mice and humans with AKI had elevated levels of monocyte chemoattractant protein-1 (MCP-1) as well as its mRNA (the template for protein synthesis).

This suggests that the gene that encodes MCP-1 and its mRNA is activated in patients with AKI, said the researchers.

Previous studies have found MCP-1, which plays a role in recruiting immune cells to injured or infected sites in the body, in the joints of patients with rheumatoid arthritis and in the urine of people with lupus.

Using a new technique called chromatin immunoprecipitation assay, the scientists were also able to show changes in proteins (known as histones) that can activate the gene that produces MCP-1. This is the first study to show that these protein modifiers can be detected in human urine.

The research will be published in an upcoming issue of the Journal of the American Society of Nephrology.

"This is a new diagnostic test that provides information about what processes are actually inducing acute kidney injury; however, a much larger prospective study is required to ultimately determine clinical utility," wrote Dr. Richard Zager of the clinical research division at Fred Hutchinson Cancer Research Center and colleagues in a news release from the publisher.

More information

The U.S. National Kidney Disease Education Program explains how to keep kidneys healthy.

-- Robert Preidt

SOURCE: American Society of Nephrology, news release, Nov. 11, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Color, Odor Changes in Urine Usually -- But Not Always -- Harmless, Reports Harvard Women's Health Watch
2. Autism finding could lead to simple urine test for the condition
3. Moving Closer to a Urine Test for Colon Cancer
4. Urine test for kidney cancer a step closer to development
5. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
6. Prognostic markers for prostate cancer patients who receive radiation after surgery
7. Radiation pharmacogenomics identifies biomarkers that could personalize cancer treatment
8. Mayo researchers find biomarkers for personalizing radiation cancer treatment
9. Biomarkers May Aid in Early Diagnosis of Alzheimers
10. NIH launches effort to define markers of human immune responses
11. Biomarkers Could Spot Alzheimers Disease Early, Studies Suggest
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Urine Markers May Reveal Kidney Damage Earlier
(Date:1/17/2017)... ... ... SunView Software’s Service Smart Technology has been selected as a finalist for ... year, Pink Elephant recognizes a new product or service developed by an IT services ... opportunity. The award highlights original innovations that were released in 2016, either as a ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... at the National Association of Music Merchants (NAMM) winter trade show, Booth #2876, ... , Etymotic’s ER•4® has long been the gold standard for high-definition, in-ear earphones. ...
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... ... as well as Palm Desert, is opening a new office in San Clemente, ... transcranial magnetic stimulation (dTMS) in Southern California, successfully treating individuals struggling with major ...
(Date:1/17/2017)... ... 17, 2017 , ... Medic-CE , a Career Step ... has released four new continuing education courses as part of its Code3 CME ... online classroom and meet the requirements of the National Continued Competency Program (NCCP), ...
(Date:1/17/2017)... ... 17, 2017 , ... Surgeons from New York’s fastest growing ... on the latest breakthroughs in the prevention, diagnosis and treatment of the most ... eye surgeon, Jeffrey Martin, MD, FACS, Chief Executive Officer of SightMD and Managing ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... Jan. 18, 2017   Seno Medical Instruments, Inc. ... breast cancer through the development of an opto-acoustic (OA/US) ... Miller as SVP of Engineering. Mr. Miller previously ... FUJIFILM SonoSite, with headquarters in Bothell, Washington ... his 30-year career to the development of innovative medical ...
(Date:1/18/2017)... Jan. 18, 2017  Tarix Orphan LLC today announced ... a Rare Pediatric Disease (RPD) designation for the company,s ... Epidermolysis Bullosa (RDEB), a rare genetic skin disorder. There ... is limited to supportive care. "The RPD ... Designation previously granted by the FDA in this indication," ...
(Date:1/18/2017)... January 18, 2017 After the recent ... the use of cannabis both for medical and recreational purposes ... Americans open to the use of cannabis, but the focus ... to Arcview Market Research, the North American legal cannabis market ... the previous year. The research projects sales will grow at ...
Breaking Medicine Technology: