Navigation Links
Urine Markers May Reveal Kidney Damage Earlier
Date:11/12/2010

THURSDAY, Nov. 11 (HealthDay News) -- Researchers have pinpointed certain markers in urine that may indicate acute kidney injury (AKI), a finding they believe could lead to a simple urine test to diagnose AKI early and prevent kidney failure.

AKI usually doesn't show obvious physical symptoms, which is why researchers are eager to find other signs of disease.

The study found that urine samples from mice and humans with AKI had elevated levels of monocyte chemoattractant protein-1 (MCP-1) as well as its mRNA (the template for protein synthesis).

This suggests that the gene that encodes MCP-1 and its mRNA is activated in patients with AKI, said the researchers.

Previous studies have found MCP-1, which plays a role in recruiting immune cells to injured or infected sites in the body, in the joints of patients with rheumatoid arthritis and in the urine of people with lupus.

Using a new technique called chromatin immunoprecipitation assay, the scientists were also able to show changes in proteins (known as histones) that can activate the gene that produces MCP-1. This is the first study to show that these protein modifiers can be detected in human urine.

The research will be published in an upcoming issue of the Journal of the American Society of Nephrology.

"This is a new diagnostic test that provides information about what processes are actually inducing acute kidney injury; however, a much larger prospective study is required to ultimately determine clinical utility," wrote Dr. Richard Zager of the clinical research division at Fred Hutchinson Cancer Research Center and colleagues in a news release from the publisher.

More information

The U.S. National Kidney Disease Education Program explains how to keep kidneys healthy.

-- Robert Preidt

SOURCE: American Society of Nephrology, news release, Nov. 11, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Color, Odor Changes in Urine Usually -- But Not Always -- Harmless, Reports Harvard Women's Health Watch
2. Autism finding could lead to simple urine test for the condition
3. Moving Closer to a Urine Test for Colon Cancer
4. Urine test for kidney cancer a step closer to development
5. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
6. Prognostic markers for prostate cancer patients who receive radiation after surgery
7. Radiation pharmacogenomics identifies biomarkers that could personalize cancer treatment
8. Mayo researchers find biomarkers for personalizing radiation cancer treatment
9. Biomarkers May Aid in Early Diagnosis of Alzheimers
10. NIH launches effort to define markers of human immune responses
11. Biomarkers Could Spot Alzheimers Disease Early, Studies Suggest
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Urine Markers May Reveal Kidney Damage Earlier
(Date:4/29/2016)... ... April 30, 2016 , ... World Patent Marketing ... Up Springboard, an automotive invention that improves the storage features of a pick ... billion," says Scott Cooper, CEO and Creative Director of World Patent Marketing. "Over ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... Footwear Foundation, the national charitable foundation serving the footwear industry, has broken all ... representing more than 130 companies across 23 states during the months of April ...
(Date:4/29/2016)... Beach, Calif. (PRWEB) , ... April 29, 2016 , ... ... us. An effective way to confront and deal with these stressors is to adopt ... bad to be good for you. Risa Groux, a certified Holistic Nutritionist and the ...
(Date:4/29/2016)... ... April 29, 2016 , ... Dr. Bernie Siegel, ... seller "LOVE, MEDICINE and MIRACLES") addresses touchy topics related to Death live on ... . Dr. Bernie Siegel, author of a plethora of essential books-to-read for ...
(Date:4/29/2016)... ... April 29, 2016 , ... Coast Dental Fort Stewart is ... its new location in the Exchange Furniture Mall at 112 Vilseck Road in Fort ... Samsung Smart TV. Plus attendees will have the opportunity to meet general dentists Thomas ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... Review, H1 2016" is a report that provides ... helps strengthen R&D pipelines by identifying new targets ... Company Profiles discussed in this H1 ... Farmaceutiche Riunite Srl, AbbVie Inc., Abiogen Pharma S.p.A., ...
(Date:4/27/2016)... 2016   ... sur le trimestre, soutenu par une croissance de ... Croissance de +16% des ventes aux hôpitaux et ... Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), inventeur de ... son chiffre d,affaires pour le premier trimestre clos ...
(Date:4/27/2016)... April 27, 2016 Transparency Market ... Devices Market - Global Industry Analysis, Size, Share, Growth, ... report, the global skincare devices market was valued at ... expand at a CAGR of 10.1% from 2015 to ... Browse the full Skincare Devices Market (Treatment Device - ...
Breaking Medicine Technology: