Navigation Links
Urine Markers May Reveal Kidney Damage Earlier
Date:11/12/2010

THURSDAY, Nov. 11 (HealthDay News) -- Researchers have pinpointed certain markers in urine that may indicate acute kidney injury (AKI), a finding they believe could lead to a simple urine test to diagnose AKI early and prevent kidney failure.

AKI usually doesn't show obvious physical symptoms, which is why researchers are eager to find other signs of disease.

The study found that urine samples from mice and humans with AKI had elevated levels of monocyte chemoattractant protein-1 (MCP-1) as well as its mRNA (the template for protein synthesis).

This suggests that the gene that encodes MCP-1 and its mRNA is activated in patients with AKI, said the researchers.

Previous studies have found MCP-1, which plays a role in recruiting immune cells to injured or infected sites in the body, in the joints of patients with rheumatoid arthritis and in the urine of people with lupus.

Using a new technique called chromatin immunoprecipitation assay, the scientists were also able to show changes in proteins (known as histones) that can activate the gene that produces MCP-1. This is the first study to show that these protein modifiers can be detected in human urine.

The research will be published in an upcoming issue of the Journal of the American Society of Nephrology.

"This is a new diagnostic test that provides information about what processes are actually inducing acute kidney injury; however, a much larger prospective study is required to ultimately determine clinical utility," wrote Dr. Richard Zager of the clinical research division at Fred Hutchinson Cancer Research Center and colleagues in a news release from the publisher.

More information

The U.S. National Kidney Disease Education Program explains how to keep kidneys healthy.

-- Robert Preidt

SOURCE: American Society of Nephrology, news release, Nov. 11, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Color, Odor Changes in Urine Usually -- But Not Always -- Harmless, Reports Harvard Women's Health Watch
2. Autism finding could lead to simple urine test for the condition
3. Moving Closer to a Urine Test for Colon Cancer
4. Urine test for kidney cancer a step closer to development
5. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
6. Prognostic markers for prostate cancer patients who receive radiation after surgery
7. Radiation pharmacogenomics identifies biomarkers that could personalize cancer treatment
8. Mayo researchers find biomarkers for personalizing radiation cancer treatment
9. Biomarkers May Aid in Early Diagnosis of Alzheimers
10. NIH launches effort to define markers of human immune responses
11. Biomarkers Could Spot Alzheimers Disease Early, Studies Suggest
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Urine Markers May Reveal Kidney Damage Earlier
(Date:6/26/2016)... ... , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center ... Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This annual ... the world’s leading providers of cereal and other breakfast foods. Its residents often refer ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... On Friday, ... presented a Bronze Wellness at Work award to iHire in recognition of their exemplary ... part of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
(Date:6/23/2016)... 23, 2016  In a startling report released today, National ... by lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... of how states are tackling the worst drug crisis in recorded ... – Kentucky , New Mexico ... . Of the 28 failing states, three – Michigan ...
Breaking Medicine Technology: