Navigation Links
Urine Markers May Reveal Kidney Damage Earlier
Date:11/12/2010

THURSDAY, Nov. 11 (HealthDay News) -- Researchers have pinpointed certain markers in urine that may indicate acute kidney injury (AKI), a finding they believe could lead to a simple urine test to diagnose AKI early and prevent kidney failure.

AKI usually doesn't show obvious physical symptoms, which is why researchers are eager to find other signs of disease.

The study found that urine samples from mice and humans with AKI had elevated levels of monocyte chemoattractant protein-1 (MCP-1) as well as its mRNA (the template for protein synthesis).

This suggests that the gene that encodes MCP-1 and its mRNA is activated in patients with AKI, said the researchers.

Previous studies have found MCP-1, which plays a role in recruiting immune cells to injured or infected sites in the body, in the joints of patients with rheumatoid arthritis and in the urine of people with lupus.

Using a new technique called chromatin immunoprecipitation assay, the scientists were also able to show changes in proteins (known as histones) that can activate the gene that produces MCP-1. This is the first study to show that these protein modifiers can be detected in human urine.

The research will be published in an upcoming issue of the Journal of the American Society of Nephrology.

"This is a new diagnostic test that provides information about what processes are actually inducing acute kidney injury; however, a much larger prospective study is required to ultimately determine clinical utility," wrote Dr. Richard Zager of the clinical research division at Fred Hutchinson Cancer Research Center and colleagues in a news release from the publisher.

More information

The U.S. National Kidney Disease Education Program explains how to keep kidneys healthy.

-- Robert Preidt

SOURCE: American Society of Nephrology, news release, Nov. 11, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Color, Odor Changes in Urine Usually -- But Not Always -- Harmless, Reports Harvard Women's Health Watch
2. Autism finding could lead to simple urine test for the condition
3. Moving Closer to a Urine Test for Colon Cancer
4. Urine test for kidney cancer a step closer to development
5. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
6. Prognostic markers for prostate cancer patients who receive radiation after surgery
7. Radiation pharmacogenomics identifies biomarkers that could personalize cancer treatment
8. Mayo researchers find biomarkers for personalizing radiation cancer treatment
9. Biomarkers May Aid in Early Diagnosis of Alzheimers
10. NIH launches effort to define markers of human immune responses
11. Biomarkers Could Spot Alzheimers Disease Early, Studies Suggest
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Urine Markers May Reveal Kidney Damage Earlier
(Date:5/24/2017)... New York, New York (PRWEB) , ... May 24, 2017 , ... ... and general vascular surgery in New York City. He is known for ... his broad specialization in vascular surgery, Dr. Benvenisty holds sub-specialty training in treating renovascular ...
(Date:5/24/2017)... ... 2017 , ... Dr. Manju R. Kejriwal, a leading Ohio dentist, is now ... a referral. Dr. Kejriwal understands the emotional and financial toll traditional orthodontics can take ... Patients no longer need to feel the esthetic effects of wires and brackets when ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... II of the HP3 (High-Performance Periodontal Practice) continuing education (CE) series. As a ... advancements in his field by attending numerous CE courses each year. His recent ...
(Date:5/24/2017)... ... 24, 2017 , ... If you are thinking of a visit to San Francisco , ... is the perfect time to visit. , Business Architecture Associates is pleased to offer 5 ... individuals, as a 4-½ day package for individuals, and as 4-½ day corporate package for ...
(Date:5/24/2017)... Falls, Wisconsin (PRWEB) , ... May 24, 2017 ... ... leader in clean label food ingredient solutions for the food and beverage industry ... factor in food ingredient statements during the purchasing decision process. As a result, ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... JERUSALEM , May 9, 2017  Oramed ... www.oramed.com ), a clinical-stage pharmaceutical company focused on ... today that the Canadian Intellectual Property Office has ... for Oral Administration of Exenatide". The patent covers ... analog. GLP-1 is an incretin hormone ...
(Date:5/6/2017)... 5, 2017   Provista , a proven leader in ... customers, today announced Jim Cunniff as the company,s ... and business experience to Provista, including most recently serving as ... California . He assumed his new role with ... great fit for Provista," says Jody Hatcher , president, ...
(Date:5/4/2017)... 2017  A recent study published in the ... light as a means of disinfection anesthesia workstations ... bioburden on anesthesia workstations. In the study, UVC ... medical equipment surfaces contaminated with three (3) organisms ... study further validates the body of literature supporting ...
Breaking Medicine Technology: