Navigation Links
Urine Markers May Reveal Kidney Damage Earlier
Date:11/12/2010

THURSDAY, Nov. 11 (HealthDay News) -- Researchers have pinpointed certain markers in urine that may indicate acute kidney injury (AKI), a finding they believe could lead to a simple urine test to diagnose AKI early and prevent kidney failure.

AKI usually doesn't show obvious physical symptoms, which is why researchers are eager to find other signs of disease.

The study found that urine samples from mice and humans with AKI had elevated levels of monocyte chemoattractant protein-1 (MCP-1) as well as its mRNA (the template for protein synthesis).

This suggests that the gene that encodes MCP-1 and its mRNA is activated in patients with AKI, said the researchers.

Previous studies have found MCP-1, which plays a role in recruiting immune cells to injured or infected sites in the body, in the joints of patients with rheumatoid arthritis and in the urine of people with lupus.

Using a new technique called chromatin immunoprecipitation assay, the scientists were also able to show changes in proteins (known as histones) that can activate the gene that produces MCP-1. This is the first study to show that these protein modifiers can be detected in human urine.

The research will be published in an upcoming issue of the Journal of the American Society of Nephrology.

"This is a new diagnostic test that provides information about what processes are actually inducing acute kidney injury; however, a much larger prospective study is required to ultimately determine clinical utility," wrote Dr. Richard Zager of the clinical research division at Fred Hutchinson Cancer Research Center and colleagues in a news release from the publisher.

More information

The U.S. National Kidney Disease Education Program explains how to keep kidneys healthy.

-- Robert Preidt

SOURCE: American Society of Nephrology, news release, Nov. 11, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Color, Odor Changes in Urine Usually -- But Not Always -- Harmless, Reports Harvard Women's Health Watch
2. Autism finding could lead to simple urine test for the condition
3. Moving Closer to a Urine Test for Colon Cancer
4. Urine test for kidney cancer a step closer to development
5. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
6. Prognostic markers for prostate cancer patients who receive radiation after surgery
7. Radiation pharmacogenomics identifies biomarkers that could personalize cancer treatment
8. Mayo researchers find biomarkers for personalizing radiation cancer treatment
9. Biomarkers May Aid in Early Diagnosis of Alzheimers
10. NIH launches effort to define markers of human immune responses
11. Biomarkers Could Spot Alzheimers Disease Early, Studies Suggest
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Urine Markers May Reveal Kidney Damage Earlier
(Date:2/27/2017)... ... February 27, 2017 , ... Anahata ... Spiritual Awakening, is happy to announce her “Spring Rejuvenation in Sedona” personally ... individual customized retreats offer the winter-weary soul an excellent opportunity to come out ...
(Date:2/27/2017)... Nashville, TN (PRWEB) , ... February 27, 2017 , ... ... Dot Clayton went to work for a company involved in the underground testing of ... , In “Dying for Answers: Expendable Workers of the Cold War Nuclear Testing,” Clayton ...
(Date:2/27/2017)... CA (PRWEB) , ... February 27, 2017 , ... ... Periodontitis is a chronic inflammatory gum condition that occurs when the bacteria in plaque ... cleaning, also referred to as a scaling and root planing or SRP, and can ...
(Date:2/27/2017)... ... February 26, 2017 , ... Miro is the ultimate ... and video system brings songs, movies, TV shows and much more apps for user ... high-definition sound. An immersive view of 1280 x 720 provides crisp images with remarkable ...
(Date:2/27/2017)... ... February 27, 2017 , ... Texas based ... In addition, Discount Power's RCE (Residential Customer Equivalent) count exceeds 150,000. ... company had 800 customers and 2,250 RCEs at the time of acquisition. In ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... , Feb. 27, 2017  RegeneRx Biopharmaceuticals, ... clinical-stage drug development company focused on tissue protection, ... for RGN-137, GtreeBNT Co., Ltd., received a positive ... 3 clinical trial design for RGN-137 to treat ... healing gel that incorporates Thymosin beta 4 ("Tß4") ...
(Date:2/27/2017)... February 27, 2017 Leading Countries, Technologies and ... is expected to grow at a CAGR of 8.9% from 2016-2021 ... grow at a CAGR of 9.1% from 2016 to 2027. The ... ... will benefit you Read on to discover how you can ...
(Date:2/27/2017)... The Hague, The Netherlands , Feb 27, 2017 /PRNewswire/ ... Sectra Tiger/R is approved by NATO for use at ... requirements on security imposed within the NATO organization for the ... ... aimed at providing government authorities with an eavesdrop-secure smartphone solution. ...
Breaking Medicine Technology: