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Urigen Announces Issuance of Key Patent for URG101 - A Novel Therapy to Treat Painful Bladder Syndrome/Interstitial Cystitis
Date:8/19/2008

BURLINGAME, Calif., August 19 /PRNewswire-FirstCall/ -- Urigen Pharmaceuticals, Inc. (OTC Bulletin Board: URGP, http://www.urigen.com), a specialty pharmaceutical company focused on the development and commercialization of treatments for urological disorders, today announced the U.S. Patent and Trademark Office has issued the first patent for the use of URG101, an investigational, bladder instillation treatment for Painful Bladder Syndrome/Interstitial Cystitis (PBS/IC). Patent number US 7,414,039 broadly covers the use of the URG101 product in the treatment of PBS/IC. The term of the patent extends into 2025.

"Not only does this patent establish protection for the use of URG101 in Painful Bladder Syndrome and Interstitial Cystitis; it also validates the excellent intellectual property guidance provided by Tom Jurgensen, JD of Catalyst Law and Stephen Reiter, PhD, JD of Foley & Lardner," stated William J. Garner, MD, President and CEO of Urigen. "We will continue to execute our intellectual property strategy to strengthen our proprietary position in the field of PBS/IC."

Urigen has announced positive results from a Phase 2 study of URG101. The study was a multi-center, double-blind, placebo-controlled, crossover trial. Findings from the study included:

-- Primary Endpoint -- Improvement in Average Daytime Pain (p=0.03).

-- Secondary Endpoints -- Improvement in Daytime Urgency (p=0.03) and Total Symptom Score (p=0.03). In addition, patients reported improved symptom relief with URG101 as measured by PORIS (p=0.01).

About URG101

URG101 is a pharmaceutical treatment for Painful Bladder Syndrome/Interstitial Cystitis that is instilled into the bladder. URG101 works with lidocaine reducing the sensations of pain, urge and muscle spasms and heparin, a glycosaminoglycan, coating the bladder wall thus augmenting the natural heparinoids.

About Painful Bladder Syndrome/In
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SOURCE Urigen Pharmaceuticals, Inc.
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