Navigation Links
Upside-down world: DNA protecting protein helps cancer drug to kill cells
Date:4/27/2009

Some DNA repair enzymes can become double-edged swords If they work too slowly, they can block necessary cell maintenance and contribute to cell death. This could explain the somewhat mysterious success of the widely used cancer drug 5-Fluorouracil (5FU) and help clinicians to predict patient's response to chemotherapy, according to new findings from the University of Basel, Switzerland. The work, published in this week's issue of PLoS Biology, reports that 5FU keeps the DNA-repair enzyme TDG too busy to perform properly in cancer cells, thereby promoting tumor death.

5FU has been used in cancer therapy for more than four decades and remains a mainstay in the treatment of colorectal cancer. But precisely how the drug kills cancerous cells was not well understood. It was generally thought that as an inhibitor of thymidylate synthase the compound worked by starving cells of the thymidine needed to make DNA.

First author on the paper Christophe Kunz and his colleagues inactivated the TDG enzyme in different human and mouse cells and found that the cells became resistant to the cancer drug. They wondered how a DNA repair enzyme could change the tolerance of cells to chemotherapy. They found that, in addition to other effects, 5FU is incorporated into DNA, in the place of the normal DNA base Thymidine. TDG identifies these 5FU insertions, and is tasked with removing the 5FU from the DNA. TDG depends on a chemical modification to leave DNA after doing its job, and its turnover is very slow. When large amounts of 5FU are present in DNA the slow turnover can overload the entire repair system. Under those circumstances, an abasic site (a site where a base is missing) is left unrepaired, and so the DNA damage response kicks in, and kills the cell. So TDG may cause the death of cells flooded with 5FU a desirable goal in tumour therapy.

"These findings provide a better understanding of how 5-Fluorouracil kills cancer cells," says Dr. Kunz, "in the future this knowledge could provide clinicians with a prognostic tool to decide which chemotherapeutic treatment to use based on the patient's level of TDG expression in the tumor cells." To this end, future research should focus on determining whether TDG expression correlates with 5FU response rates in cancer patients.


'/>"/>

Contact: Sally Hubbard
press@plos.org
Public Library of Science
Source:Eurekalert

Related medicine news :

1. Healthcare Tech and the World: Advancing Autonomy in the UK Healthcare System
2. Healthcare Tech and the World: A Discussion About the Impact of Medical Automation on Healthcare
3. The Wireless World: Untethered Opportunities
4. Healthcare Tech and the World: A Discussion About Quality Initiatives Pioneered at Ascension Health
5. HEALTHCARE TECH AND THE WORLD: A MACRO PERSPECTIVE ON HOW TECHNOLOGY WILL IMPACT HEALTHCARE IN THE FUTURE
6. Healthcare Tech and the World: A New Perspective on Innovation in Healthcare
7. HEALTHCARE TECH AND THE WORLD: HOW INFORMATION TECHNOLOGY CAN IMPACT THE PURSUIT OF PERFECT CARE
8. Healthcare Tech and the World: Personalized Technology to Benefit Healthcare Consumers in the Future
9. Healthcare Tech and the World: Podcast Examines The Challenges & Opportunities for Change in the Healthcare Industry
10. Kaiser Permanente Recognized by U.S. Environmental Protection Agency for Commitment to Protecting Environment
11. April Rain is Protecting Skin with The Launch of Day Rainew
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... February 24, 2017 , ... Only two months after the ... Market (ILTM) show in Cannes (France), XO Private has initiated a second print-run of ... book measures almost a metre across when open, weighs in at more than six ...
(Date:2/24/2017)... , ... February 24, 2017 , ... In the Health ... be a top priority because it’s not if you will be attacked, but when.” ... when it comes to digital health care. , Improvements in auditing and monitoring have ...
(Date:2/24/2017)... Diego, CA (PRWEB) , ... February 24, 2017 , ... ... its 2017 national conference convening academic faculty engaged in or interested in palliative care ... and Research,” will be held in North County San Diego on Sept. 28 ...
(Date:2/24/2017)... ... February 24, 2017 , ... Rosica Communications, ... thought leadership , media relations, social media, content marketing and SEO, is ... powered through Act-On, an intuitive marketing automation platform. , Rosica will now offer ...
(Date:2/23/2017)... ... 2017 , ... The 89th Academy Awards will be celebrated this weekend, which ... Center Bunkum Award. We invite you to enjoy our 11th annual tongue-in-cheek “salute” to ... the Center for American Progress (CAP), for its report, Lessons From State Performance on ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... 23, 2017  Genesis Healthcare Services has merged with ... made by Bill Monast , President and CEO ... Nathan Feltman , executives with Home Health Depot, ... This acquisition helps Hospice Cloud maintain ... enabled durable medical equipment (DME) solutions for the hospice ...
(Date:2/23/2017)... Feb. 23, 2017 Nevro Corp. (NYSE: NVRO), a ... for the treatment of chronic pain, today reported financial results ... 2016. 2016 Accomplishment & Highlights: ... 2016, an increase of 228% as reported, over the prior ... an increase of 612% over the prior year ...
(Date:2/23/2017)... 2017 Research and Markets has announced the ... 2016" report to their offering. ... The latest research Fibromyalgia Drugs Price Analysis ... the global Fibromyalgia market. The research answers the following ... for Fibromyalgia and their clinical attributes? How are they positioned in ...
Breaking Medicine Technology: