Navigation Links
Upside-down world: DNA protecting protein helps cancer drug to kill cells
Date:4/27/2009

Some DNA repair enzymes can become double-edged swords If they work too slowly, they can block necessary cell maintenance and contribute to cell death. This could explain the somewhat mysterious success of the widely used cancer drug 5-Fluorouracil (5FU) and help clinicians to predict patient's response to chemotherapy, according to new findings from the University of Basel, Switzerland. The work, published in this week's issue of PLoS Biology, reports that 5FU keeps the DNA-repair enzyme TDG too busy to perform properly in cancer cells, thereby promoting tumor death.

5FU has been used in cancer therapy for more than four decades and remains a mainstay in the treatment of colorectal cancer. But precisely how the drug kills cancerous cells was not well understood. It was generally thought that as an inhibitor of thymidylate synthase the compound worked by starving cells of the thymidine needed to make DNA.

First author on the paper Christophe Kunz and his colleagues inactivated the TDG enzyme in different human and mouse cells and found that the cells became resistant to the cancer drug. They wondered how a DNA repair enzyme could change the tolerance of cells to chemotherapy. They found that, in addition to other effects, 5FU is incorporated into DNA, in the place of the normal DNA base Thymidine. TDG identifies these 5FU insertions, and is tasked with removing the 5FU from the DNA. TDG depends on a chemical modification to leave DNA after doing its job, and its turnover is very slow. When large amounts of 5FU are present in DNA the slow turnover can overload the entire repair system. Under those circumstances, an abasic site (a site where a base is missing) is left unrepaired, and so the DNA damage response kicks in, and kills the cell. So TDG may cause the death of cells flooded with 5FU a desirable goal in tumour therapy.

"These findings provide a better understanding of how 5-Fluorouracil kills cancer cells," says Dr. Kunz, "in the future this knowledge could provide clinicians with a prognostic tool to decide which chemotherapeutic treatment to use based on the patient's level of TDG expression in the tumor cells." To this end, future research should focus on determining whether TDG expression correlates with 5FU response rates in cancer patients.


'/>"/>

Contact: Sally Hubbard
press@plos.org
Public Library of Science
Source:Eurekalert

Related medicine news :

1. Healthcare Tech and the World: Advancing Autonomy in the UK Healthcare System
2. Healthcare Tech and the World: A Discussion About the Impact of Medical Automation on Healthcare
3. The Wireless World: Untethered Opportunities
4. Healthcare Tech and the World: A Discussion About Quality Initiatives Pioneered at Ascension Health
5. HEALTHCARE TECH AND THE WORLD: A MACRO PERSPECTIVE ON HOW TECHNOLOGY WILL IMPACT HEALTHCARE IN THE FUTURE
6. Healthcare Tech and the World: A New Perspective on Innovation in Healthcare
7. HEALTHCARE TECH AND THE WORLD: HOW INFORMATION TECHNOLOGY CAN IMPACT THE PURSUIT OF PERFECT CARE
8. Healthcare Tech and the World: Personalized Technology to Benefit Healthcare Consumers in the Future
9. Healthcare Tech and the World: Podcast Examines The Challenges & Opportunities for Change in the Healthcare Industry
10. Kaiser Permanente Recognized by U.S. Environmental Protection Agency for Commitment to Protecting Environment
11. April Rain is Protecting Skin with The Launch of Day Rainew
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... ... , ... Leading dental clinicians, Drs. Ashlyn Price, Autumn Mayers and Ron Adelman, ... systems. With advanced digital images and modeling capabilities, the dentists identify all of the ... oral health for those who are missing teeth in Midlothian, VA. , ...
(Date:6/20/2017)... ... June 20, 2017 , ... This year, participants in the ... finding product improvements that could reduce the occurrence of unplanned extubations (UEs). ... breathing or to provide medication. Sometimes, patient movement can cause unplanned extubations which ...
(Date:6/20/2017)... ... June 20, 2017 , ... BrightStar Care Centerville/South Dayton, a ... the Joint Commission, which accredits and certifies nearly 21,000 healthcare organizations and programs ... a symbol of quality that reflects an organization’s commitment to meeting certain performance ...
(Date:6/20/2017)... ... June 20, 2017 , ... The law firm of ... installation as the president of the DuPage County Bar Association’s Board of Directors. Cassioppi ... June 9 at the Drake in Oak Brook. Momkus McCluskey Roberts LLC attorney Stacey ...
(Date:6/19/2017)... ... 19, 2017 , ... Intrinsic Clinical Systems announced it will ... actionable insights to improve health globally through the advancement of lifesaving medicines and ... faster, easier, and less painful. Attendees can visit Intrinsic’s booth showcasing its four ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... , June 14, 2017  In 2016, ... Creative Startups pitch competition and came away with ... platform is described by Forbes as "entering the life ... Medical Association as teaching "empathy to medical professionals in ... startup was recently named a finalist for the Department ...
(Date:6/9/2017)... 9, 2017 AirXpanders, Inc. (ASX: AXP) (AirXpanders ... design, manufacture, sale and distribution of the AeroForm® Tissue ... of its commercial roll-out in the United ... than one hundred (100) medical institutions and health systems, ... a needle-free alternative for women who choose reconstructive surgery ...
(Date:6/7/2017)... June 7, 2017 Endo International plc (NASDAQ: ... 2017, the Hon. Joseph R. Goodwin , U.S. ... West Virginia , entered a case management ... Repair System Products Liability Litigation (the "MDL") that includes ... to provide expert disclosures on specific causation within one ...
Breaking Medicine Technology: