Navigation Links
Upending a cancer dogma
Date:7/2/2014

Researchers at the University of California, San Diego School of Medicine say a protein essential to regulating cell cycle progression the process of cell division and replication activates a key tumor suppressor, rather than inactivating it as previously thought.

"The finding is the result of literally 20 years of work in my lab," said Steven F. Dowdy, PhD, professor in the Department of Cellular and Molecular Medicine at UC San Diego. "It completely turns upside-down what was thought to be a fundamental aspect of cell cycle progression in all cancer cells driven by one of the most common genetic pathways mutated in cancer, namely the p16-cyclin D pathway."

The findings are published in the journal eLife.

Cyclin D is synthesized during the first stage of cell replication and is believed to help drive the complex, multi-stage process, including interaction with the retinoblastoma (Rb) protein, whose function is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. Rb acts as a tumor suppressor.

But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been described as an oncogene that promotes cancer because it was believed to inactivate the Rb tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.

Dowdy and colleagues painstakingly counted the number of phosphates added to Rb during cell cycle progression. There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor. The single phosphate serves to activate Rb, not inactivate it as had been thought for over 20 years.

The researchers said the findings fundame
'/>"/>

Contact: Jackie Carr
jcarr@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Cancer Research UKs new funding scheme to nurture future world-leading scientists
2. Biomarker predicts effectiveness of brain cancer treatment
3. GW researcher receives more than $1 million in grants to study epigenetics of pancreatic cancer
4. For cancer patients, sugar-coated cells are deadly
5. Mayo Clinic: Proton therapy has advantages over IMRT for advanced head and neck cancers
6. Mayo Clinic researchers reveal treasure trove of genes key to kidney cancer
7. Enlightening cancer cells
8. Cancer risk: Aspirin and smoking affect aging of genes
9. EORTC presents European solution for effective cancer drug development
10. New approach identifies cancer mutations as targets of effective melanoma immunotherapy
11. Case Western Reserve, University Hospitals fundraising for adolescent, young adult cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Upending a cancer dogma
(Date:3/29/2015)... North American Seminars receives Texas Board ... Education Courses . , Utilizing Pilates to ... TPTA, approval # 56399TX      , The Interactive ... complex - 10.5 hours - Texas Board of Physical ... Treatment of the SI Joint - 10 hours - ...
(Date:3/28/2015)... "Necrorun" was featured on NewsWatch as part of ... latest and coolest applications on the market for iOS, ... and technology expert, conducted the app review and shared ... game with knights, nature, and peasants. , The ... to Eurogamer. The popularity of these games grew over ...
(Date:3/28/2015)... Emergency Medical Care (EMC), a New York ... commemorated its three-year anniversary of being the only 24/7 ... 24-hour urgent care, Emergency Medical Care offers its clients ... Emergency Medical Care’s Urgent Care NYC services ... injuries, ear infections, fevers, insect bites, burns, animal bites, ...
(Date:3/28/2015)... NV (PRWEB) March 28, 2015 One ... re-injury, according to research presented today at the American ... Day. The study examined the long term success of ... , “We examined survey data from 242 patients who ... author Justin P. Roe, MBBS, FRACS, from North Sydney ...
(Date:3/28/2015)... Andrew Hawley of Vintage Rock Posters Inc., ... posters. The Who and the Doors played together at the ... According to Hawley, “The Who toured the United States heavily ... campuses. Perhaps the most famous Who poster was a poster ... Doors on August 2, 1968 at the Singer Bowl in ...
Breaking Medicine News(10 mins):Health News:A Grim Endless Runner Game Was Featured on NewsWatch Television on January 30, 2015 2Health News:Emergency Medical Care Celebrates Three Years of 24/7 Walk-In Urgent Care Services 2Health News:Young Athletes at Greater Risk for Re-Injury after ACL Surgery 2Health News:Avid Collector from Vintage Rock Posters, Inc. Announces His Search For Original 1960's Who Psychedelic Concert Posters. 2
... individuals, who constitute a rapidly growing population in the ... care utilization and cost. Yet more than ... age or age-related conditions, according to a new study ... the University of Michigan. "These findings are ...
... an inexpensive, FDA-approved hypertension medication may improve the ... In a report in the early edition of ... , Massachusetts General Hospital (MGH) investigators describe experiments ... the network of collagen fibers that characterizes most ...
... available in French . Montreal, February 2, ... (LGB) are at far higher risk for severe mental health ... suggests that the stress of being rejected or victimized because ... and bisexuals. Recently published as a doctoral thesis ...
... German . Lung tumors are the number one ... is lung cancer. Each year, there are 50,000 new cases of ... detected, the greater the chance of healing the patient. But early ... chronic inflammatory reactions. To get a more complete diagnosis, the patient ...
... thought to be active in killing cells also promotes cellular ... of RIP1 is actually necessary for survival of septic injury, ... potential for developing new treatments for sepsis PROVIDENCE, ... protein that plays a dual role in the liver during ...
... Children who grow up in poverty have health problems as ... live in communities with more social cohesiveness and control get ... be obese as adolescents. The new study, published in ... Psychological Science, is part of a long-term examination of children ...
Cached Medicine News:Health News:Older adults often excluded from clinical trials 2Health News:Generic drug may improve the effectiveness of cancer nanotherapies 2Health News:Physiological impacts of homophobia 2Health News:Physiological impacts of homophobia 3Health News:Early detection of lung cancer 2Health News:The 'death switch' in sepsis also promotes survival 2Health News:Having a strong community protects adolescents from risky health behaviors 2
(Date:3/27/2015)... March 27, 2015 Zimmer Holdings, Inc. (NYSE and SIX: ZMH) ... ® Complete Knee System. ... th year since Zimmer first introduced the NexGen knee ... date, more than five million implantations of the NexGen knee ... the NexGen knee demonstrates the importance of design innovation and ...
(Date:3/27/2015)... Report Details  New study shows ... What does the future hold for top companies ... new report shows you potential revenues to 2025, assessing ... 242-page report provides 185 tables, charts, and graphs. Discover ... future market prospects. Our new study lets you assess ...
(Date:3/27/2015)... 2015 The International Myeloma Foundation (IMF) – ... working toward prevention and a cure – today commended ... federal resolution (H. Res. 174) that supports the designation ... Myeloma Awareness Month." Currently there are more ... than 110,000 new cases are diagnosed yearly, according to ...
Breaking Medicine Technology:Zimmer Celebrates Key Milestones For NexGen Complete Knee System 2Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 2Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 3Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 4Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 5Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 6Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 7The International Myeloma Foundation (IMF) Secures the Introduction of a Federal Resolution Recognizing March 2015 as "National Multiple Myeloma Awareness Month" 2
... WASHINGTON, Sept. 1, 2011 Lung Cancer ... approval of Xalkori (crizotinib) with non-small cell lung cancer ... based on data from two clinical trials, both of ... Xalkori targets the echinoderm microtubule-associated protein-like 4-anaplastic ...
... Sept. 1, 2011 Roche Diabetes Care, makers of ... is proud to host its second annual Infusion Site ... highlight the importance of proper infusion site management for ... 1 diabetes who use an insulin pump. ...
Cached Medicine Technology:New Drug Approved for Treatment of Non Small Cell Lung Cancer in Specific Patient Population 2Roche Diabetes Care Celebrates Second Annual Infusion Site Awareness Week, Aug. 29-Sept. 4 2Roche Diabetes Care Celebrates Second Annual Infusion Site Awareness Week, Aug. 29-Sept. 4 3
Lorgnette pinhole occluder...
9 inch double ended with one end black and the other end with 49 holes...
6 inch hand held occlcuder with 49 holes...
Double Ended Occluders...
Medicine Products: