Navigation Links
Upending a cancer dogma
Date:7/2/2014

Researchers at the University of California, San Diego School of Medicine say a protein essential to regulating cell cycle progression the process of cell division and replication activates a key tumor suppressor, rather than inactivating it as previously thought.

"The finding is the result of literally 20 years of work in my lab," said Steven F. Dowdy, PhD, professor in the Department of Cellular and Molecular Medicine at UC San Diego. "It completely turns upside-down what was thought to be a fundamental aspect of cell cycle progression in all cancer cells driven by one of the most common genetic pathways mutated in cancer, namely the p16-cyclin D pathway."

The findings are published in the journal eLife.

Cyclin D is synthesized during the first stage of cell replication and is believed to help drive the complex, multi-stage process, including interaction with the retinoblastoma (Rb) protein, whose function is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. Rb acts as a tumor suppressor.

But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been described as an oncogene that promotes cancer because it was believed to inactivate the Rb tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.

Dowdy and colleagues painstakingly counted the number of phosphates added to Rb during cell cycle progression. There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor. The single phosphate serves to activate Rb, not inactivate it as had been thought for over 20 years.

The researchers said the findings fundame
'/>"/>

Contact: Jackie Carr
jcarr@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Cancer Research UKs new funding scheme to nurture future world-leading scientists
2. Biomarker predicts effectiveness of brain cancer treatment
3. GW researcher receives more than $1 million in grants to study epigenetics of pancreatic cancer
4. For cancer patients, sugar-coated cells are deadly
5. Mayo Clinic: Proton therapy has advantages over IMRT for advanced head and neck cancers
6. Mayo Clinic researchers reveal treasure trove of genes key to kidney cancer
7. Enlightening cancer cells
8. Cancer risk: Aspirin and smoking affect aging of genes
9. EORTC presents European solution for effective cancer drug development
10. New approach identifies cancer mutations as targets of effective melanoma immunotherapy
11. Case Western Reserve, University Hospitals fundraising for adolescent, young adult cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Upending a cancer dogma
(Date:1/22/2015)... Hawley, PA (PRWEB) January 22, 2015 Woodloch ... Pocono Mountains, has been selected by TripAdvisor as the number ... and the 6th best in the world for their annual ... online travel community . The website is home to ...
(Date:1/22/2015)... a famous wedding dress company offering many trendy designs. Today, ... Twitter, and Pinterest. The fans will have an opportunity to ... week. , Moreover, the company has extended its 2015 New ... for more information. , Angelweddingdress is a famous ...
(Date:1/22/2015)... A new white paper by The ... in the long-term care environment as well as provides ... The paper, “The Power of Person-Centeredness in Long-Term Care: ... of the patient, resident and family experience in long-term ...
(Date:1/22/2015)... NJ (PRWEB) January 22, 2015 Joan ... and keynote speaker at the upcoming 32nd Annual ... ACCME-accredited Physicians’ Education Resource®, LLC (PER®) , shares ... would have gone undetected if she had not followed ...
(Date:1/22/2015)... Four years since the release of their debut ... the marriage of Avasa & Matthew Love – the duo are ... for release through White Swan Records on February 24, 2015. , ... sacred path available to all of us to walk out of ...
Breaking Medicine News(10 mins):Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4
... the UNH scientist, the beginning of 'natural spring' starts a ... result of global warming, has made an impact in the ... the happenings takes place in nature. ,The sun will ... equinox and the official start of spring, but Mother Nature ...
... however tired or sleep deprived you are! Two-thirds of ... pillows and accompaniments and are simply tossing around till ... by more than 4 hours on each night, according ... indicates the unhealthy implications of sleep deprivation that include ...
... renewed his motivation to fight setbacks after watching a spider weave ... there are quite a few of us , who cannot look ... the web ! If creeps and spiders make you run a ... ,Arachnophobia, or any phobia for that matter could be alleviated ...
... release on the 28th regarding a study on stethoscope accuracy ... that physicians with more experience // are better able to ... heart disease. The researchers felt that with a greater experience ... pathologic heart disorders., ,Publishing their findings in the March ...
... a pilot study conducted by Jiahai Lu, Ph.D., of ... said that passive immunotherapy// is the best way to ... ,Passive immunotherapy uses antibodies from horses. Purified antibodies ... from horses were used against mice and it proved ...
... been developed at Leeds that will benefit at large ... for the next generation// of miniaturized computers. ,By ... Williams and Dr Yulong Ding have created ‘nanofluids’ which ... liquids. In a central heating system, nanofluids could increase ...
Cached Medicine News:Health News:‘Natural Spring’ Starts A Week Ahead Now Than Before: UNH Scienti 2Health News:‘Natural Spring’ Starts A Week Ahead Now Than Before: UNH Scienti 3Health News:Phobia Attack: Courting Fear with Cortisol, the Stress Hormone 2Health News:Experienced Physicians Diagnose Heart Disease’s Earlie 2Health News:Passive Immunotherapy Could Prevent Avian Flu from Affecting Humans 2
(Date:1/23/2015)... 23, 2015  CytoSorbents Corporation (NASDAQ CM: CTSO), a ... cytokine adsorber to reduce deadly inflammation in critically-ill ... $385,642, net of transaction costs, in non-dilutive funding ... Tax Certificate Transfer Program sponsored by the New ...
(Date:1/22/2015)... a privately held medical device company, announced today that ... ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) to sell ... cancer in Japan . ViewRay,s technology, ... only MRI-guided radiation therapy system that images and treats ...
(Date:1/22/2015)... THOUSAND OAKS, Calif. , Jan. 22, 2015  Amgen (NASDAQ: ... quarter and full year 2014 financial results on Tuesday, Jan. 27, ... will be followed by a conference call with the investment community ... be Robert A. Bradway , chairman and chief executive officer, ...
Breaking Medicine Technology:CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2
... Companies to Lead Public and Investor Relations -- BEIJING, Sept. 9 /PRNewswire-Asia-FirstCall/ -- ... ... (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, ...
... The Prix Galien USA committee, responsible for awarding the ... announced the 2010 winner of the Pro Bono Humanum ... competition. The award, recognizing exemplary and innovative efforts to ... in partnership with the Clinton Health Access Initiative (CHAI) ...
Cached Medicine Technology:Dehaier Medical Systems Announces Engagement of RedChip Companies to Lead Public and Investor Relations 2Dehaier Medical Systems Announces Engagement of RedChip Companies to Lead Public and Investor Relations 3Dehaier Medical Systems Announces Engagement of RedChip Companies to Lead Public and Investor Relations 4Dehaier Medical Systems Announces Engagement of RedChip Companies to Lead Public and Investor Relations 5Dehaier Medical Systems Announces Engagement of RedChip Companies to Lead Public and Investor Relations 6Dehaier Medical Systems Announces Engagement of RedChip Companies to Lead Public and Investor Relations 7Dehaier Medical Systems Announces Engagement of RedChip Companies to Lead Public and Investor Relations 82010 Prix Galien USA Pro Bono Humanum Award to be Presented to UNITAID for Work In Global HIV/AIDS Effort 2
Adsons bayonet forceps....
... Medpor Channel Implants, designed to ... the surgeon with an excellent ... wall and floor blowout defects. ... for placement of one or ...
... Rim is designed to augment ... the midface, including the inferior ... positioned in the hollow under ... Rim implant aids in restoring ...
Flattened points in vertical plane, straight shafts, cross action, round handle....
Medicine Products: