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Updating family history of cancer associated with need for earlier or more intense cancer screening
Date:7/12/2011

butions and affiliations, financial disclosures, funding and support, etc.

Editorial: Recording, Interpreting, and Updating the Family History of Cancer

In an accompanying editorial, Louise S. Acheson, M.D., M.S., of Case Western Reserve University School of Medicine, Cleveland, writes that studies regarding screening must take into account risks, benefits, costs, and lead time issues.

"It is plausible but still unknown whether family history increases the likelihood that breast cancers, prostate cancers, or colon adenomas found by screening are clinically significant. An increase in the incidence of false-positive results and test-associated complications is a cost and potential harm of increased screening based on familial risk. Although some prospective data on the benefits of cancer screening based on familial risk are available, many estimates rely on extrapolation from small studies of patients with high-penetrance hereditary cancer susceptibility or from screening older patients at equivalent levels of risk."

(JAMA. 2011;306[2]208-210. Available pre-embargo to the media at www.jamamedia.org)

Editor's Note: Please see the article for additional information, including other affiliations, financial disclosures, funding and support, etc.


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Contact: Sue McGreevey
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JAMA and Archives Journals
Source:Eurekalert

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