Navigation Links
Updating family history of cancer associated with need for earlier or more intense cancer screening
Date:7/12/2011

In an analysis to examine how often throughout adulthood clinically significant changes occur in a patient's family history of cancer, researchers found substantial changes in family history of colorectal, breast, and prostate cancer between the ages of 30 and 50 years, which would result in recommendations for earlier or more intense cancer screening, according to a study in the July 13 issue of JAMA. The authors suggest that a patient's family history of cancer be updated at least every 5 to 10 years.

"One of the most effective tools to identify individuals at increased risk of cancer is to ascertain their family history. For example, having one or more close relatives with colorectal cancer increases risk from 2-fold to 6-fold. Individuals at increased risk of colorectal, breast, or prostate cancer due to family history are recommended to begin screening for these cancers earlier and in some cases using more sensitive methods than average-risk individuals," according to background information in the article. It is recommended that primary care clinicians collect a detailed family cancer history including age at diagnosis for affected first- and second-degree relatives. Little is known about how often clinically important changes in cancer family history occur over time that could change individual's risk and the need for earlier or intensive screening.

Argyrios Ziogas, Ph.D., of the University of California-Irvine, and colleagues conducted a study to quantify how often clinically significant changes in family history of breast, colorectal, or prostate cancer occur throughout adulthood. The study included an examination of baseline and follow-up family history data from participants in the Cancer Genetics Network (CGN), a U.S. national population-based cancer registry, between 1999 and 2009. Participants included adults with a personal history, family history, or both of cancer enrolled in the CGN through population-based cancer registries. Retrospective colorectal, breast, and prostate cancer screening-specific analyses included 9,861, 2,547, and 1,817 participants, respectively; prospective analyses included 1,533, 617, and 163 participants, respectively. Median (midpoint) follow-up was 8 years. The primary outcomes measured included percentage of individuals with clinically significant family histories and rate of change over two periods: (1) retrospectively, from birth until CGN enrollment and (2) prospectively, from enrollment to last follow-up.

The researchers found that retrospective analysis indicated that the percentages of participants who met criteria for high-risk screening based on family history at ages 30 and 50 years, respectively, were as follows: for colorectal cancer, 2.1 percent and 7.1 percent; for breast cancer, 7.2 percent and 11.4 percent; and for prostate cancer, 0.9 percent and 2.0 percent. "In prospective analysis, the numbers of participants who newly met criteria for high-risk screening based on family history per 100 persons followed up for 20 years were 2 for colorectal cancer, 6 for breast cancer, and 8 for prostate cancer. The rate of change in cancer family history was similar for colorectal and breast cancer between the 2 analyses," the authors write.

"Both analyses demonstrate that clinically relevant family history changes substantially during early and middle adulthood, particularly for colorectal and breast cancer, for which the percentage recommended for high-risk screening increases 1.5- to 3-fold between ages 30 and 50 years."

The researchers recommend that family cancer history should be updated at least every 5 to 10 years to appropriately inform recommendations for cancer screening.

(JAMA. 2011;306[2]172-178. Available pre-embargo to the media at www.jamamedia.org)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Recording, Interpreting, and Updating the Family History of Cancer

In an accompanying editorial, Louise S. Acheson, M.D., M.S., of Case Western Reserve University School of Medicine, Cleveland, writes that studies regarding screening must take into account risks, benefits, costs, and lead time issues.

"It is plausible but still unknown whether family history increases the likelihood that breast cancers, prostate cancers, or colon adenomas found by screening are clinically significant. An increase in the incidence of false-positive results and test-associated complications is a cost and potential harm of increased screening based on familial risk. Although some prospective data on the benefits of cancer screening based on familial risk are available, many estimates rely on extrapolation from small studies of patients with high-penetrance hereditary cancer susceptibility or from screening older patients at equivalent levels of risk."

(JAMA. 2011;306[2]208-210. Available pre-embargo to the media at www.jamamedia.org)

Editor's Note: Please see the article for additional information, including other affiliations, financial disclosures, funding and support, etc.


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Updating ethical guidelines for biomedical engineering
2. Changes in family history of cancer can impact screening recommendations
3. Family meals remain important through teen years, expert says
4. National quality committee recognizes UT family medicine clinic in TMC
5. Targeting the Ewing sarcoma family of tumors
6. Many Fathers Struggle to Balance Work, Family: Survey
7. When cancer runs in the family
8. No health card means no family doctor for many homeless people
9. Family Medical History Murky for Many
10. Researchers find increasing the number of family physicians reduces hospital readmissions
11. Family Meals Keep Kids Slimmer, Healthier, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... January 20, 2017 , ... Source Vitál Apothecary, a skin and body care ... announced the company had a successful visit to the 2017 ECRM Diet, Vitamin & ... that work in the nutritional, sports and health industries a chance to meet in ...
(Date:1/20/2017)... Florida (PRWEB) , ... January 20, 2017 , ... Lice ... head lice cases in families with school-aged children since the holiday season. , ... the holidays with their families, sharing hugs and taking photos, which is the head-to-head ...
(Date:1/20/2017)... ... ... Michael and Betsy Brauser celebrated 5 years of Betsy’s participation in a ... has been life-saving as she has been on the trial for more than six ... ovarian cancer in 2009. She underwent standard chemotherapy but a year later went to ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... “Mary Magdalene: ... the mysterious life of the woman who witnessed Jesus Christ firsthand. “Mary Magdalene: Grace ... denizen, who spent her career as an educator interacting with countless women who had ...
(Date:1/20/2017)... , ... January 20, 2017 , ... “I Forgive You”: a fine examination of ... Forgive You” is the creation of published author, Stephen Miller, who, for over ten long ... gracefully given to him. Born in Trinidad and Tobago, he has been serving the Lord ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Jan. 19, 2017 Report Details ... Alzheimer,s ... Leading Companies – our new study reveals trends, R&D ... and events affecting the Alzheimer,s disease therapeutics and diagnostics ... these key questions: - How is the Alzheimer,s disease ...
(Date:1/19/2017)... Incretin Mimetics/GLP-1 Agonists, SNDRIs, Lipase Inhibitors, Serotonin Receptor Agonists, Sympathomimetic-GABA Receptor ... market is expected to grow at a CAGR of 27.1% ... 38.7% in the second half of the forecast period. The market ... to 2027. The market is estimated at $1,058 million in 2016, ... ...
(Date:1/19/2017)... LONDON , January 19, 2017 ... Grothey ; European Oncology & Haematology, 2016;12(Suppl 2):3-8; ... ... http://photos.prnewswire.com/prnh/20151014/276718LOGO) Published recently in ... the peer-reviewed journal from touchONCOLOGY, an article by ...
Breaking Medicine Technology: