Navigation Links
Update: 50 percent of patients in Cedars-Sinai brain cancer study alive after 5 years
Date:11/23/2013

LOS ANGELES (NOV. 23, 2013) Eight of 16 patients participating in a study of an experimental immune system therapy directed against the most aggressive malignant brain tumors glioblastoma multiforme survived longer than five years after diagnosis, according to Cedars-Sinai researchers, who presented findings Nov. 23 at the Fourth Quadrennial Meeting of the World Federation of Neuro-Oncology.

Seven of the 16 participants still are living, with length of survival ranging from 60.7 to 82.7 months after diagnosis. Six of the patients also were "progression free" for more than five years, meaning the tumors did not return or require more treatment during that time. Four participants still remain free of disease with good quality of life at lengths ranging from 65.1 to 82.7 months following diagnosis. One patient who remained free of brain cancer for five years died of leukemia.

The original clinical trial a Phase I study designed to evaluate safety included 16 patients with glioblastoma multiforme enrolled between May 2007 and January 2010 by researchers at Cedars-Sinai's Johnnie L. Cochran, Jr. Brain Tumor Center.

Results published in January at the end of the study showed median overall survival of 38.4 months. Typically, when tumor-removal surgery is followed by standard care, which includes radiation and chemotherapy, median length of survival is about 15 months. Median progression-free survival the time from treatment to tumor recurrence was 16.9 months at study's end. With standard care, the median is about seven months.

The experimental treatment consists of a vaccine, ICT-107, intended to alert the immune system to the existence of cancer cells and activate a tumor-killing response. It targets six antigens involved in the development of glioblastoma cells.

According to information presented at the scientific meetings, all eight long-term survivors had tumors with at least five antigens, 75 percent had tumors with all six, and 100 percent had tumors with at least four antigens associated with cancer stem cells cancer-originating cells that appear to enable tumors to resist radiation and chemotherapy and even regenerate after treatment.

"Our findings suggest that targeting antigens that are highly expressed by cancer stem cells may be a viable strategy for treating patients who have glioblastomas. Long-term remission of disease in this group of patients was correlated with the expression of cancer stem cell tumor-associated antigens," said Surasak Phuphanich, MD, director of the Neuro-Oncology Program at the Cochran Brain Tumor Center and professor of neurology with Cedars-Sinai's Department of Neurosurgery and Department of Neurology.

Based on results of the Phase I study, the ICT-107 vaccine entered a Phase II multicenter, randomized, placebo-controlled trial in 2011.

The vaccine is based on dendritic cells, the immune system's most powerful antigen-presenting cells those responsible for helping the immune system recognize invaders. They are derived from white blood cells taken from each participating patient in a routine blood draw. In the laboratory, the cells are cultured with synthetic peptides of the six antigens essentially training the dendritic cells to recognize the tumor antigens as targets. When the "new" dendritic cells in the vaccine are injected under the patient's skin, they are intended to seek and destroy lingering tumor cells. Vaccine is administered three times at two-week intervals after standard radiation and chemotherapy.

Phuphanich is first author of an abstract presented at the scientific meetings' poster session from 5 to 7 p.m. PST Nov. 23.

ICT-107 is a product of the biotechnology company ImmunoCellular Therapeutics, Ltd. Cedars-Sinai owns equity in the company, and certain rights in the dendritic cell vaccine technology and corresponding intellectual property have been exclusively licensed by Cedars-Sinai to ImmunoCellular Therapeutics, including rights associated with ICT-107, the vaccine investigated in this clinical study.

Several members of the research and presentation team have ties to the company. Abstract co-author Keith Black, MD, a Cedars-Sinai physician, owns stock in the company. Senior author John Yu, MD, a Cedars-Sinai physician, owns stock in the company and is its founder, chief scientific officer and chair of the board of directors. James Bender, PhD, MPH, a co-author, is Immunocellular Therapeutics' vice president for product development and manufacturing. Elma Hawkins, a co-author, also is identified with Immunocellular.


'/>"/>

Contact: Sandy Van
sandy@prpacific.com
808-526-1708
Cedars-Sinai Medical Center
Source:Eurekalert

Related medicine news :

1. HRT Update: Therapy May Reduce Fractures, Boost Some Risks
2. Transvaginal Mesh Lawsuit Update: New Study Concerning Use of Vaginal Mesh in Prolapse Procedures, Bernstein Liebhard LLP Reports
3. Cell Phone Radiation Lawsuit Update: ICEMS Position Paper Supports Italian Supreme Court Ruling on Cell Phones and Brain Tumors, Bernstein Liebhard LLP Reports
4. DrugRisk Update: NuvaRing Lawsuit Trials to Begin This Year
5. DrugRisk Update: Court Allows Charges of Prior Fraud Into Pradaxa Lawsuit
6. DrugRisk Pradaxa Lawsuit Update: Court Denys Boehringer’s Protective Order Request
7. DrugRisk Pradaxa Update: Litigation Grows As New Study Adds to Risks
8. Research update: Chemists find help from nature in fighting cancer
9. Yasmin Blood-Clotting Lawsuits Update: Resource4thePeople Providing Legal Assistance as Concerns Rise Over Health Risks
10. Tylenol Liver Failure Allegation Lawsuits Update: Resource4thePeople Reports Hearing to Consolidate Federal Cases Is Scheduled
11. DrugRisk Update: Bayer Discloses $500 Million Remaining for Yaz Lawsuits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... Brady ... announced that its B-595 and B-7569 vinyl label materials received ... and warning labels are tested to remain intact and legible, for use on chemical ...
(Date:4/21/2017)... ... April 21, 2017 , ... The VIA Agency ... (AOR) for Theravent, Inc. , the makers of a revolutionary new device ... Healthcare, is now working to expand distribution in anticipation of a national launch. ...
(Date:4/21/2017)... ... 21, 2017 , ... Airway Management, the medical device manufacturer ... regarded and well renowned Asian distributor, Discovery Sleep. The agreement involves ... Mask, and will stabilize and strengthen Airway’s presence with a dedicated, reputable medical ...
(Date:4/21/2017)... ... 21, 2017 , ... BrightStar Care Salt Lake City, a home care agency ... (APCUT) and has appointed Rex Wheeler as its new Director of Business Development. “This ... and our ability to provide quality care to the community,” said Tammara Brown, owner ...
(Date:4/21/2017)... ... April 21, 2017 , ... Federal mandate, fines, controversy, questions ... the Obamacare program that most Republicans love to hate and Texas Agriculture Commissioner ... hogs. , Like Obamacare, the Miller program centers upon a federal mandate. ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... April 18, 2017  Astute Medical, Inc., developer of ... to be presented at the 2017 National Kidney Foundation ... and continues through April 22. Physicians will present data ... to assess risk for acute kidney injury (AKI) during ... (ADHF). Elevated levels of TIMP-2 and ...
(Date:4/18/2017)... April 18, 2017  Socionext Inc. and SOINN ... in 2016, in which Socionext extracts and delivers ... companies achieved initial results in reading ultrasound images ... Brain SOINN. The results will be introduced at ... 19-21, at booths 4505 & 4507. ...
(Date:4/18/2017)... Mass. , April 18, 2017  Spero Therapeutics, ... for the treatment of bacterial infections, will present preclinical ... the treatment of multidrug resistant (MDR) Gram-negative infections at ... Diseases (ECCMID) April 22-25, 2017 in Vienna, ... ...
Breaking Medicine Technology: