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UofL researchers uncover mechanism in saliva production
Date:6/2/2011

Secretory Protein (PSP), selectively and directly binds to a rare lipid, a type of fat molecule called PtdIns(3,4)P2, present only in certain cell membranes - and only present on one side of the membrane. Darling also found PtdIns(3,4)P2 can flip to the inner part of the vesicle membrane giving PSP the opportunity to bind it.

"These data imply that phosphatidylinositol-phosphate lipids like PtdIns(3,4)P2 may have multiple functions on the inner surface of organelles," Darling said. "This is contrary to the current belief that their functions are always limited to one surface of the cell membrane."

The next step is for Darling and his team to identify the molecular components used for flipping PtdIns(3,4)P2, and develop approaches to test ways to manipulate this potential protein sorting mechanism.


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Contact: Julie Heflin
julie.heflin@louisville.edu
502-852-7987
University of Louisville
Source:Eurekalert

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