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UofL receives $5.5 million grant from Helmsley Charitable Trust
Date:5/16/2014

team that created the world's first cervical cancer vaccine. Drs. Bennett Jenson and Shin-Je Ghim are working on a vaccine that is biosimilar to the original vaccine, but produced in tobacco plants. This effort also will enter into the pre-IND phase over the next two years.

Drs. Nobuyuki Matoba and Palmer are developing an oral cholera vaccine that may prove to be a way to prevent colon cancer. The gastrointestinal issues associated with cholera create a favorable environment for the development of colon cancer, thus, preventing cholera can also prevent colon cancer. The goal is for this vaccine to enter clinical trials in late 2014.

For several years, Dr. Huang-Ge Zhang has been exploring the anticancer properties of tiny particles called plant exosomes. Animal studies suggest that exosomes may be able to play a role in the treatment or prevention of colon, breast and lung cancer. Zhang was the first to demonstrate that exosomes existed in plants and plans to demonstrate that they could be used to deliver higher concentrations of anticancer drugs directly to human tumors.

Dr. Ramesh Gupta has uncovered that certain compounds within colored berries increase the anticancer effect of chemotherapy drugs. This has the potential to enable smaller amounts of the drugs to be used, but with the same or more beneficial effects.

"Our goal is to cure cancer in people, not in mice," Miller said. "The Owensboro Cancer Research Program is a tremendous tool for reaching that goal, not just locally or regionally, but worldwide. Through plant-based pharmaceuticals, we will be able to provide low-cost vaccines and anticancer medications that make them accessible to even the poorest of nations. To have an organization like the Helmsley Charitable Trust partner with us will enable us to move toward our goal at a much quicker pace."

UofL's comprehensive campaign is scheduled to wrap up June 30 after already surpassing its $1 billion goal. Ch
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Contact: Gary Mans
gary.mans@louisville.edu
502-852-7504
University of Louisville
Source:Eurekalert  

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UofL receives $5.5 million grant from Helmsley Charitable Trust
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