Navigation Links
Unusual suspect: Hopkins scientists find 'second fiddle' protein's role in Type 2 diabetes
Date:4/11/2013

PAC2-deficient and normal pancreatic cells under a microscope, the investigators found that the EPAC2-deficient cells were unable to regulate calcium, a well-known catalyst that triggers the release of insulin into the blood. EPAC2 functioned as calcium's gatekeeper, the researchers say. In its absence, calcium did not reach the critical mass needed to initiate the release of insulin.

The researchers say it remains unclear whether type 2 diabetes damages EPAC2 directly or whether EPAC2 can coax the cells to crank out extra insulin only for so long and eventually gives up. Either way, Hussain says, targeting EPAC2 with drugs could ratchet up the beta cells' dwindling insulin production and nip, or even reverse, diabetes at its root.

Type 2 diabetes is the predominant form of the disease, accounting for more than 90 percent of all diabetes diagnoses. It is commonly associated with diet and lifestyle. Previously seen mostly in middle-aged and older adults, type 2 diabetes is now increasingly diagnosed in younger people and children, a phenomenon fueled by growing obesity rates, experts say.


'/>"/>

Contact: Ekaterina Pesheva
peshev1@jhmi.edu
410-502-9433
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Unusual protein helps regulate key cell communication pathway
2. Abnormal gene product associated with prostate cancer generated by unusual mechanism
3. 29 Johns Hopkins stem cell researchers awarded funding
4. Johns Hopkins African bioethics program receives 5-year continuation grant from NIH
5. Johns Hopkins researchers return blood cells to stem cell state
6. Johns Hopkins team finds ICU misdiagnoses may account for as many annual deaths as breast cancer
7. Johns Hopkins Armstrong Institute receives $8.9 million patient safety grant
8. Hopkins scientists discover how an out-of-tune protein leads to muscle demise in heart failure
9. Johns Hopkins scientists pair blood test and gene sequencing to detect cancer
10. In US first, Johns Hopkins surgeons implant brain pacemaker for Alzheimers disease
11. Johns Hopkins study reveals what makes nonprofits special
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... (PRWEB) July 28, 2014 FAA-certified ... pilot an airplane, helicopter, gyroplan or airship, and should ... to pilot balloons and gliders are exempt from the ... physical exam is to alert potential pilots and contractors ... aviation. By detecting these conditions early, the physicians at ...
(Date:7/28/2014)... A lush green lawn offers the perfect setting for backyard ... heat, lack of rain, foot traffic, and insects can often ... Grounds Guys recommends these suggestions for nurturing your summer lawn: ... and set the height on the lawn mower about one ... heat and allows roots to retain water and grow more ...
(Date:7/28/2014)... July 28, 2014 Quincy Bioscience, makers ... is pleased to announce the release of the fourth ... president and co-founder Mark Underwood. , The Brain Health ... offering useful techniques for readers to improve memory and ... unavoidable conclusion, The Brain Health Guide provides ways to ...
(Date:7/28/2014)... 2014 (HealthDay News) -- Elementary school students seem to be ... according to a new study of school officials. , , ... Agriculture -- went into effect in the fall of 2012. ... buying lunch, or throw away most of their food. But ... this isn,t the case. , , "The updated meals standards ...
(Date:7/28/2014)... July 28, 2014 Shofner Vision ... Military June . Renowned LASIK and Cataract Surgeon, ... provide significant funds and public awareness for local ... military personnel and their families. “This was our ... give nearly $5,000 to a variety of local ...
Breaking Medicine News(10 mins):Health News:Healthpointe Invites All Aspiring Pilots to Complete an FAA Certified Exam 2Health News:Nurturing Lawns in the Summer Heat: The Grounds Guys® Offers Tips on Caring for Lawns This Summer 2Health News:Quincy Bioscience Launches the Fourth Edition of The Brain Health Guide 2Health News:Healthy School Lunches Get Thumbs Up From Students 2Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 2Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 3
... Launched officially today, the Institute on Asian Consumer Insight (ACI) ... centre for companies seeking to grow their business in Asia. ... Summit, organised with the Financial Times. Modelled in format after ... attended by global business leaders, will be a platform to ...
... the United States live with epilepsy, a complex brain disorder ... rate of onset occurs in children and older adults, and ... this common disorder is widely misunderstood. Epilepsy refers to ... cause, severity, and frequency. Many people do not know ...
... estimates that 1 in 88 children in the United States has ... and Prevention released a report Thursday (March 29) that looked at ... The new data show that autism rates in ... found 1 in 110 children were diagnosed with autism or a ...
... (HealthDay News) -- Doctors may fail to detect precancerous ... a colonoscopy, a new study warns. On the ... eating solid food and to consume only clear liquids. ... However, previous research suggests that up to one-quarter ...
... HealthDay Reporter , THURSDAY, March 29 (HealthDay News) -- ... dating for America,s adolescents, a new survey reveals. Researchers ... than 37 percent of 11- to 14-year olds had been ... one in six said they had fallen prey to physical ...
... HealthDay Reporter , THURSDAY, March 29 (HealthDay News) -- ... flavanols -- the antioxidants found in cocoa beans. ... cocoa might affect blood pressure, heart disease, painful nerve ... Wednesday at the American Chemical Society,s annual meeting in ...
Cached Medicine News:Health News:National institute launched to help businesses grow with Asian consumers 2Health News:National institute launched to help businesses grow with Asian consumers 3Health News:National institute launched to help businesses grow with Asian consumers 4Health News:National institute launched to help businesses grow with Asian consumers 5Health News:IOM report identifies public health actions for improving the lives of those with epilepsy 2Health News:Inadequate Bowel Prep May Invalidate Colonoscopy 2Health News:Dating Violence Common by 7th Grade: Survey 2Health News:Dating Violence Common by 7th Grade: Survey 3Health News:Chocolate a Sweet Remedy for Many Ills? 2Health News:Chocolate a Sweet Remedy for Many Ills? 3Health News:Chocolate a Sweet Remedy for Many Ills? 4
(Date:7/28/2014)... 28, 2014 Southern Research Institute today ... President and CEO of Southern Research Institute, has ... (CRS) for the 2014-2015 term.  The inauguration took ... 12 in Chicago with ... The Controlled Release Society is an international, ...
(Date:7/28/2014)... -- Research and Markets  has announced the addition of ... to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... inflammation and pain in the human body,s joints such as ... inflammation of the tissues that surround the joints and in ... begin slowly, usually just mild pain around the joints coupled ...
(Date:7/28/2014)... AUSTIN, Texas , July 28, 2014  MedSpring Urgent Care, ... new walk-in clinic at 517 S. Lamar Blvd., Austin, ... urgent care clinic is located on the southeast corner of ... doctor on-site from 9 a.m. - 9 p.m. daily, including weekends ... University of Texas, Central Austin , Anderson ...
Breaking Medicine Technology:Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 2Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 3Global Rheumatoid Arthritis Drugs Market 2014-2018 2MedSpring Urgent Care opens Barton Springs walk-in clinic in Austin, TX 2
... Calif., Oct. 7 Onyx Pharmaceuticals, Inc. (Nasdaq: ... its New Drug Application (NDA) filing for carfilzomib based ... Controls (CMC) review division of the U.S. Food and ... information related to commercial-scale manufacturing of carfilzomib.  Onyx had ...
... NEW YORK, Oct. 7 Reportlinker.com announces that a ... European RIS/PACS Market ... European RIS/PACS market in terms of the challenges faced ... The main chapters of the research service include an ...
Cached Medicine Technology:Onyx Pharmaceuticals Provides Status Update on Carfilzomib 2Onyx Pharmaceuticals Provides Status Update on Carfilzomib 3Reportlinker Adds European RIS/PACS Market 2Reportlinker Adds European RIS/PACS Market 3
... Self-Cath family of 100% ... a variety of options ... Each catheter is made ... PVC and has smooth ...
Used for intermittent catheterization of a male or female patient to provide drainage of urine from the bladder. Supplied sterile in peel-open packages. Intended for one-time use....
An enzyme-linked immuno-sorbent assay for the detectionand quantitation of anti-tissue Transglutaminase in serum of patients with Celiac Disease and Dermatitis Herpetiformis....
... Scoliosis Brace™ for neuromuscular scoliosis ... lightweight, soft, and easy to ... comfort. The Soft Boston ... non-cracking orthopedic grade copolymer and ...
Medicine Products: