Navigation Links
Unusual suspect: Hopkins scientists find 'second fiddle' protein's role in Type 2 diabetes
Date:4/11/2013

ne-secreting pancreatic cells known as islets of Langerhans to keep up with the body's demand for insulin. Insulin regulates blood sugar by transporting glucose from the blood into organs and tissues for fuel or storage. The body normally releases extra insulin when blood sugar levels surge after eating, but repeated or continued overeating and high-fat diets put added demand on the pancreas to churn out more insulin to keep up with constantly high blood sugar levels. The chronically overworked beta cells eventually slow down their insulin output until it ceases altogether. Insulin deficiency causes abnormal buildup of glucose in the blood and the body's inability to deliver it as fuel to organs and tissues. This, the researchers say, is the essence of diabetes.

Working with mice whose pancreatic cells were missing the EPAC2 signaling molecule, the researchers found that lean, healthy mice regulated their blood sugar levels even in the absence of EPAC2. Short-term surges in food consumption did not affect the mice's ability to regulate their blood sugar, but when the mice were put on a high-fat diet for a month, they developed a condition similar to human diabetes. At the same time, a group of overfed, pudgy mice with intact EPAC2 managed to control blood sugar levels without a problem. In other words, EPAC2 remained dormant and played no role in insulin production under normal conditions, but emerged as a critical factor when the fat mice needed more insulin to control their surging blood sugar levels. This finding led the scientists to believe EPAC2 is an important fail-safe mechanism unlocked only during abnormal conditions.

"It is as if during these extreme conditions, the body calls upon EPAC2 as backup to help it balance insulin supply and demand," Hussain says.

The study further reveals that EPAC2 is critical because it acts as a link in a signaling cascade that culminates in the release of insulin by pancreatic cells. Comparing E
'/>"/>

Contact: Ekaterina Pesheva
peshev1@jhmi.edu
410-502-9433
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Unusual protein helps regulate key cell communication pathway
2. Abnormal gene product associated with prostate cancer generated by unusual mechanism
3. 29 Johns Hopkins stem cell researchers awarded funding
4. Johns Hopkins African bioethics program receives 5-year continuation grant from NIH
5. Johns Hopkins researchers return blood cells to stem cell state
6. Johns Hopkins team finds ICU misdiagnoses may account for as many annual deaths as breast cancer
7. Johns Hopkins Armstrong Institute receives $8.9 million patient safety grant
8. Hopkins scientists discover how an out-of-tune protein leads to muscle demise in heart failure
9. Johns Hopkins scientists pair blood test and gene sequencing to detect cancer
10. In US first, Johns Hopkins surgeons implant brain pacemaker for Alzheimers disease
11. Johns Hopkins study reveals what makes nonprofits special
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... Harvard neuroscientists have made a discovery that turns 160 ... electrical insulating material long known to be essential for ... nerve cells, is not as ubiquitous as thought, according ... of the Harvard Stem Cell Institute (HSCI) and the ... collaboration with Professor Jeff Lichtman, of Harvard,s Department of ...
(Date:4/18/2014)... did it make you feel? According to psychologists, remembering ... as how sad you were or how embarrassed you ... can,t stop thinking about it. , When these ... the memories, rather than how you felt, is a ... effects of these memories, a new study suggests. , ...
(Date:4/18/2014)... Fraser University psychologists have made a brain-related discovery ... attention-deficit disorders. , This discovery opens up the ... or suppress a specific brain activity that the ... , The Journal of Neuroscience has ... John McDonald, an associate professor of psychology and ...
(Date:4/18/2014)... This news release is available in French . ... breakthrough could revolutionize surgical practice and regenerative medicine. A ... Molle et Chimie (CNRS/ESPCI Paris Tech) and Didier Letourneur ... and Paris 13), has just demonstrated that the principle ... used in vivo to repair soft-tissue organs and tissues. ...
(Date:4/17/2014)... The presence of chronic inflammation in benign ... prostate cancer, and this association was found even ... according to a study published in Cancer ... the American Association for Cancer Research. , An ... participants of the placebo arm of the Prostate ...
Breaking Medicine News(10 mins):Health News:Finding turns neuroanatomy on its head 2Health News:Finding turns neuroanatomy on its head 3Health News:New study suggests a better way to deal with bad memories 2Health News:New study suggests a better way to deal with bad memories 3Health News:Scientists discover brain's anti-distraction system 2Health News:Innovative strategy to facilitate organ repair 2Health News:Innovative strategy to facilitate organ repair 3Health News:Chronic inflammation may be linked to aggressive prostate cancer 2Health News:Chronic inflammation may be linked to aggressive prostate cancer 3
... at Jefferson have found a mechanism by which a ... makes breast cancer more aggressive. Publishing in the ... prolactin, a pituitary hormone that normally stimulates breast development ... oncogene called BCL6. The BCL6 protein has previously been ...
... Predictive, Preventive and Personalised Medicine have founded, as the ... Creating a reliable scientific platform for the optimal combination ... laboratory medicine, the EPMA Journal will highlight ... and personalised medicine. The EPMA Journal ...
... , CARROLLTON, Texas , Feb. ... (AAUCM) has begun a sponsorship of the A-Claim™ medical payment ... , A-Claim ( www.A-Claim.com ) is a proprietary medical payment ... Carrollton, Texas , that is changing the way physicians, hospitals ...
... Nixon declared a "War on Cancer," the disease still claims ... expenditure of $5 billion by the U.S. government on research ... made since Nixon,s call to action in 1971, cancer research ... which is only increasing as scientists discover new drugs and ...
... ... As Strauss Radio Strategies continues to grow and expand, it has ... signing onto the GSA Schedule - the federal government procurement system. Government ... base and the addition to the GSA schedule will greatly facilitate the ...
... ... , ... February 3, 2010 -- Governance, Risk and Compliance (GRC) leader MetricStream ... over 2008 combined with record profits. MetricStream’s growth was fueled by companies prioritizing their need ...
Cached Medicine News:Health News:Springer publishes new journal in predictive, preventive and personalized medicine 2Health News:Urgent Care Providers Tout Benefits of A-Claim Medical Payment Solution 2Health News:Urgent Care Providers Tout Benefits of A-Claim Medical Payment Solution 3Health News:Developing a cyberinfrastructure for comparative effectiveness in cancer research 2Health News:Developing a cyberinfrastructure for comparative effectiveness in cancer research 3Health News:Developing a cyberinfrastructure for comparative effectiveness in cancer research 4Health News:Developing a cyberinfrastructure for comparative effectiveness in cancer research 5Health News:Strauss Radio Strategies - The Nation's Leading Radio Media Relations Firm - Expands Government Business with Award on GSA Schedule 2Health News:Strauss Radio Strategies - The Nation's Leading Radio Media Relations Firm - Expands Government Business with Award on GSA Schedule 3Health News:MetricStream Achieves Record Revenue Growth in 2009 with Global Customer Adoption of its Enterprise GRC Platform and Solutions 2Health News:MetricStream Achieves Record Revenue Growth in 2009 with Global Customer Adoption of its Enterprise GRC Platform and Solutions 3Health News:MetricStream Achieves Record Revenue Growth in 2009 with Global Customer Adoption of its Enterprise GRC Platform and Solutions 4
(Date:1/15/2014)... , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds ... its store . (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ... upgrade and policy support, China,s ... years, with total market size rising from 3.28 billion ...
(Date:1/15/2014)... Texas , Jan. 15, 2014  Novation, the leading ... awarded several new IT value-added reseller (VAR) national contracts ... IT goods and services at lower costs. These include ... services such as initiative assistance and ongoing IT consulting ...
(Date:1/15/2014)... BreedIT Corp (OTC: BRDT), through its ... highly sophisticated agro-breeding solutions for plant breeders and researchers, ... board of directors appointed chemistry and pharmaceutical industry expert ... of the board. From 1975 to 2012, ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3
... 2011 Omnicell, Inc . (NASDAQ: ... and supply management solutions and analytics software for ... Hospital (RVH) selected Omnicell G4 solutions to ... Omnicell,s hallmark flexibility and functionality, RVH became the ...
... 26, 2011 PolyGel, the manufacturer of Orthopedic, ... long term exclusive distribution agreement with China National ... in Beijing, China, Sinopharm Foreign Trade is a ... (SINOPHARM Group). (Photo:   http://photos.prnewswire.com/prnh/20110726/NY40954 ...
Cached Medicine Technology:Royal Victoria Hospital Selects Omnicell to Improve Patient Safety with Automated Medication Management 2Royal Victoria Hospital Selects Omnicell to Improve Patient Safety with Automated Medication Management 3Royal Victoria Hospital Selects Omnicell to Improve Patient Safety with Automated Medication Management 4PolyGel Signs Long Term Exclusive Agreement With China's Largest Distributor of Healthcare Products 2
... The PK Super-Sect is a ... tissue removal with minimal thermal spread ... for superior hemostatis. It can be ... gland and/or bladder tumor. It is ...
... CS is a fully ... treatment system designed to ... unlimited flexibility. Cryocare CS ... specific physician needs through ...
... Oncura's SeedNet system is a minimally invasive ... to learn and simple to use, SeedNet ... the cryoablation process. SeedNet is the ... Ultra-thin needles, exclusive to the SeedNet system, ...
Medium Clip Appliers. American-made stainless steel, 6" long, curved tip. For use with VE-6-25 and VE-6-10 titanium surgical clips only....
Medicine Products: