Navigation Links
Unusual suspect: Hopkins scientists find 'second fiddle' protein's role in Type 2 diabetes
Date:4/11/2013

A team of researchers at the Johns Hopkins Children's Center has found that a protein long believed to have a minor role in type 2 diabetes is, in fact, a central player in the development of the condition that affects nearly 26 million people in the United States alone and counts as one of the leading causes of heart disease, stroke and kidney, eye and nerve damage.

Working with mice, the scientists discovered that a protein called EPAC2 deemed a second-fiddle player up until now is actually an important regulator of insulin that appears to work by nudging insulin-secreting cells of the pancreas to ramp up production of the sugar-regulating hormone when the body needs it most. Until now, EPAC2 was suspected of playing a merely supporting role as a signaling molecule, but scientists remained uncertain why and how that mattered, if at all.

The results of the federally funded research, described online April 11 in the journal Diabetes, also suggest EPAC2 could provide an important new target for treatment to restore pancreatic cell function, the researchers say. Current diabetes treatments halt disease progression at best and focus on controlling symptoms and averting complications, so therapies that actually reverse the disease are badly needed.

"Drugs that precision-target failing pancreatic cells and restore or boost their function have become the holy grail of diabetes research. We believe that our finding establishes a pathway to do just that," says lead investigator Mehboob Hussain, M.D., a pediatric endocrinologist at the Johns Hopkins Children's Center and a metabolism expert at the newly formed Johns Hopkins Diabetes Institute.

The researchers say several experimental compounds known to alter EPAC2 are now lined up for testing in diabetic animals, but caution that their findings remain far from human application.

Type 2 diabetes stems from the failure of beta cells members of a family of hormo
'/>"/>

Contact: Ekaterina Pesheva
peshev1@jhmi.edu
410-502-9433
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Unusual protein helps regulate key cell communication pathway
2. Abnormal gene product associated with prostate cancer generated by unusual mechanism
3. 29 Johns Hopkins stem cell researchers awarded funding
4. Johns Hopkins African bioethics program receives 5-year continuation grant from NIH
5. Johns Hopkins researchers return blood cells to stem cell state
6. Johns Hopkins team finds ICU misdiagnoses may account for as many annual deaths as breast cancer
7. Johns Hopkins Armstrong Institute receives $8.9 million patient safety grant
8. Hopkins scientists discover how an out-of-tune protein leads to muscle demise in heart failure
9. Johns Hopkins scientists pair blood test and gene sequencing to detect cancer
10. In US first, Johns Hopkins surgeons implant brain pacemaker for Alzheimers disease
11. Johns Hopkins study reveals what makes nonprofits special
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... 2015 , ... The 2015 ALS Ice Bucket Challenge will officially get underway ... Sox honor Ice Bucket co-founders Pat Quinn and Pete Frates, the ALS community and ... efforts among the ALS organizations to find treatments and cures for the disease. ...
(Date:7/31/2015)... ... July 31, 2015 , ... BioViva USA, Inc. (“BioViva”), a to-clinic gene therapy ... , BioViva announces it has begun a fundraiser through Maximum Life Foundation (“MaxLife”) ... find a cure. MaxLife will grant 100% of the money raised to BioViva to ...
(Date:7/31/2015)... ... July 31, 2015 , ... Like nearly every other form of surgery, it ... made more effective and less intrusive and painful. Leading these advances in the ... Dr. Loria currently stands as the only doctor in the United States who is ...
(Date:7/31/2015)... ... 2015 , ... Recently, ZKB filed another federal lawsuit in ... No. 3:15-cv-00397) involving the Implanon® contraceptive implant . , As described in ... implants, inability to locate the implants, unsuccessful and invasive attempts at implant removal, ...
(Date:7/31/2015)... ... July 31, 2015 , ... Successful ... DC, http://www.fdanews.com/importexportprogram , Having FDA-regulated products held at ports costs time, ... of risking containment — or even destruction — of products, an FDA insider ...
Breaking Medicine News(10 mins):Health News:Major League Baseball Joins MDA and Fourteen Other ALS Organizations to Launch ALS Ice Bucket Challenge 2015 2Health News:Major League Baseball Joins MDA and Fourteen Other ALS Organizations to Launch ALS Ice Bucket Challenge 2015 3Health News:Major League Baseball Joins MDA and Fourteen Other ALS Organizations to Launch ALS Ice Bucket Challenge 2015 4Health News:BioViva USA, Inc.’s Alzheimer’s Disease Gene Therapy Human Trial 2Health News:BioViva USA, Inc.’s Alzheimer’s Disease Gene Therapy Human Trial 3Health News:Loria Medical Penile Enlargement Center to Expand, Offering Practice Partnership to Doctors 2Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 2Health News:Can Implanon® (Etonogestrel Implant) Go Missing? Zoll, Kranz & Borgess, LLC Files Another Lawsuit on Behalf of Women with Lost or Migrated Implanon® Implants 3Health News:FDAnews Announces — Successful Import/Export Programs: Former FDA Expert Shows the Way, Oct. 20-21, 2015 2Health News:FDAnews Announces — Successful Import/Export Programs: Former FDA Expert Shows the Way, Oct. 20-21, 2015 3Health News:FDAnews Announces — Successful Import/Export Programs: Former FDA Expert Shows the Way, Oct. 20-21, 2015 4
... of Pennsylvania School of Medicine and other study sites ... non-invasive technique that excites neurons in the brain via ... safe and effective, non-drug treatment with minimal side effects ... treatment options without benefit. , This study ...
... generates green pods while a variant of that gene ... helped Gregor Mendel, the 19th century Austrian priest and ... are focused on the strange ability of some genes ... ways. , In order to better understand this phenomenon ...
... researchers have identified structural damage to the lungs caused ... the study, conducted by researchers at the University of ... Hospital of Philadelphia in Pennsylvania, were presented today at ... America (RSNA). , Its long been hypothesized that prolonged ...
... of Australias leading medical,research institutes, unveiled a powerful ... cutting edge in medical technology and microscopy, the ... scientists at the Centenary Institute,unprecedented access to the ... and molecular,level., The Centenary Institute is equally excited ...
... CARLSBAD, Calif., Nov. 26 Visage Imaging, a,wholly ... MRCY ),announced an agreement with Siemens Medical ... solutions to hospitals and imaging,centers worldwide., Siemens ... into its SIENET Magic product line. This unique ...
... Ohio, Nov. 26 Understand how improving ... That,s the message behind,the new book "REM ... by Timothy J. Walter, M.D., a sleep ... (Lotus Magnus, August,2007, ISBN-13: 978-1604022377, $19.95) integrates ...
Cached Medicine News:Health News:Penn research shows transcranial magnetic stimulation effective in treating major depression 2Health News:Flip-flopping gene expression can be advantageous 2Health News:Novel MRI technique shows secondhand smoke damages lungs 2Health News:World class technology and talent battle cancer at the Centenary Institute 2Health News:Visage Imaging Expands Availability of Its Advanced Visualization Offering 2Health News:Visage Imaging Expands Availability of Its Advanced Visualization Offering 3Health News:Understand How Sleep Impacts Learning and Memory 2
(Date:7/30/2015)... , July 30, 2015 ... new research report with market overview, trends, ... forecast, porter analysis, recent developments, competitive scenario ... Global Industry Insight: Biosensors Market Development and ... (Logo: http://photos.prnewswire.com/prnh/20150727/756778 ) Explore ...
(Date:7/30/2015)...   Gaumard® Scientific Company today announced ... first operating system to support an entire family ... Gaumard users. UNI® version 2.27.21.0 adds enhanced functionality ... as well as improvements to laboratory functions, patient ... as EtCO 2 .  First ...
(Date:7/30/2015)... 2015   Sentrian , the Remote Patient ... recently received confirmation from the Food & Drug ... solution meets the definition of a "medical device" ... Discretion." The designation identifies medical ... regulatory requirements at this time" and clears the ...
Breaking Medicine Technology:Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 2Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 3Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 4Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 5Gaumard's Latest UNI Operating System Update Adds Performance and New Functionality 2Gaumard's Latest UNI Operating System Update Adds Performance and New Functionality 3FDA Clears Way for Commercial Marketing of Sentrian Remote Patient Intelligence Solution 2FDA Clears Way for Commercial Marketing of Sentrian Remote Patient Intelligence Solution 3
... Effectiveness of Autologous Therapy, DUSSELDORF, Germany, ... two-year,representative study of knee osteoarthritis, published in ... safety and effectiveness of Orthokine therapy, in ... blood are,injected into the arthritic joint., ...
... New Therapeutic Platform in Patients with Cystoid Macular ... ... Aug. 5 Icon Bioscience, Inc., (IBI),a privately held ophthalmic pharmaceutical ... clinical trial to assess the,safety and efficacy of its lead product, ...
Cached Medicine Technology:Orthokine Treatment is Effective for Knee Arthritis, Even After Two Years 2Icon Bioscience Completes Enrollment in Phase I Study of Novel Ophthalmic Drug Candidate 2
The Leica M500 OH3 is an advanced surgical microscope used by neurosurgeons. It is a smart system combining the best optical performance available on the market with an innovative and unique stand....
Surgical Loupes...
... MAGNETOM Allegra is the ultimate brain ... been optimized for best image quality ... all in a highly compact design. ... diagnosing stroke, epilepsy, tumor and multiple ...
Signa Profile is built on the Signa foundation to deliver speed & image quality....
Medicine Products: