Navigation Links
Unusual comparison nets new sleep loss marker
Date:5/3/2013

For years, Paul Shaw, PhD, a researcher at Washington University School of Medicine in St. Louis, has used what he learns in fruit flies to look for markers of sleep loss in humans.

Shaw reverses the process in a new paper, taking what he finds in humans back to the flies and gaining new insight into humans as a result: identification of a human gene that is more active after sleep deprivation.

"I'm calling the approach cross-translational research," says Shaw, associate professor of neurobiology. "Normally we go from model to human, but there's no reason why we can't take our studies from human to model and back again."

Shaw and his colleagues plan to use the information they are gaining to create a panel of tests for sleep loss. The tests may one day help assess a person's risk of falling asleep at the wheel of a car or in other dangerous contexts.

PLOS ONE published the results on April 24.

Scientists have known for years that sleep disorders and disruption raise blood serum levels of interleukin 6, an inflammatory immune compound. Shaw showed that this change is also detectable in saliva samples from sleep-deprived rats and humans.

Based on this link, Shaw tested the activity of other immune proteins in humans to see if any changed after sleep loss. The scientists took saliva samples from research participants after they had a normal night's sleep and after they stayed awake for 30 hours. They found two immune genes whose activity levels rose during sleep deprivation.

"Normally we would do additional human experiments to verify these links," Shaw says. "But those studies can be quite expensive, so we thought we'd test the connections in flies first."

The researchers identified genes in the fruit fly that were equivalent to the human genes, but their activity didn't increase when flies lost sleep. When they screened other, similar fruit fly genes, though, the scientists found one that did.

"We've seen this kind of switch happen before as we compared families of fly genes and families of human genes," Shaw says. "Sometimes the gene performing a particular role will change, but the task will still be handled by a gene in the same family."

When the scientists looked for the human version of the newly identified fly marker for sleep deprivation, they found ITGA5 and realized it hadn't been among the human immune genes they screened at the start of the study. Testing ITGA5 activity in the saliva samples revealed that its activity levels increased during sleep deprivation.

"We will need more time to figure out how useful this particular marker will be for detecting sleep deprivation in humans," Shaw says. "In the meantime, we're going to continue jumping between our flies and humans to maximize our insights."


'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Related medicine news :

1. Unusual suspect: Hopkins scientists find second fiddle proteins role in Type 2 diabetes
2. Abnormal gene product associated with prostate cancer generated by unusual mechanism
3. Unusual protein helps regulate key cell communication pathway
4. Premier Provider of Hearing Aids in Santa Monica CA, American Hearing & Balance, Announces New Hearing Aid Comparison Chart
5. The Hearing Center of Lake Charles, Number One Provider of Hearing Aids in Lake Charles LA, Announces New Comparison Guide
6. The cost of prescription drugs -- a comparison of 2 countries
7. Comparison of Obesity Surgeries Turns Up Surprising Results
8. A comparison of 2 home exercises to treat vertigo
9. Sleep duration associated with higher colorectal cancer risk
10. Affordable Acupuncture Practice Helps South Florida Residents Relieve Pain, Sleep Better, Reduce Stress and More
11. Sleep Apnea is a Worldwide Epidemic: Better Rest Solutions Helps Spread Awareness on Sleep Apnea Awareness Day
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
(Date:10/12/2017)... ... , ... The American College of Medical Informatics (ACMI) will present the 2017 ... Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is ... pioneer in the field of medical informatics, this prestigious award is presented to an ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, ... a medical article to the newly revamped Cosmetic Town journal section, ... hair transplant procedure known as Follicular Unit Extraction (FUE). , Dr. ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the Health & ... by Moonlight to raise money for the American Heart Association Heart Walk. Teams of ... will work together to keep their treadmills moving for 5 hours. Treadmills will start ...
(Date:10/12/2017)... ... October 12, 2017 , ... In the ... a year. In some states—like New York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, ... retirement havens have extremely low property-tax rates, which contributes to the relatively lower ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... Mich. , Sept. 18, 2017  PMD Healthcare ... Specialty Pharmacy of Kalamazoo, Mich. , ... hub service that expedites and streamlines patient and provider ... PD 2.0, and wellness management services.  ... device used to measure lung function for a variety ...
(Date:9/12/2017)... NEW YORK , Sept. 12, 2017   EcoVadis , the ... chains, has published the first annual edition of its Global CSR Risk ... 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings that analyzed nearly ... ... Performance Index ...
(Date:9/9/2017)... 2017 ... coming to Washington DC ... Tuesday, September 12 th – Monday, September 18 th .The Brain ... MRI brain scans to the public.Where:  BTF,s Mobile ... 501 K Street NW, Washington, D.C.What:BTF brings its nationwide initiative, the Road ...
Breaking Medicine Technology: