Navigation Links
Unusual comparison nets new sleep loss marker
Date:5/3/2013

For years, Paul Shaw, PhD, a researcher at Washington University School of Medicine in St. Louis, has used what he learns in fruit flies to look for markers of sleep loss in humans.

Shaw reverses the process in a new paper, taking what he finds in humans back to the flies and gaining new insight into humans as a result: identification of a human gene that is more active after sleep deprivation.

"I'm calling the approach cross-translational research," says Shaw, associate professor of neurobiology. "Normally we go from model to human, but there's no reason why we can't take our studies from human to model and back again."

Shaw and his colleagues plan to use the information they are gaining to create a panel of tests for sleep loss. The tests may one day help assess a person's risk of falling asleep at the wheel of a car or in other dangerous contexts.

PLOS ONE published the results on April 24.

Scientists have known for years that sleep disorders and disruption raise blood serum levels of interleukin 6, an inflammatory immune compound. Shaw showed that this change is also detectable in saliva samples from sleep-deprived rats and humans.

Based on this link, Shaw tested the activity of other immune proteins in humans to see if any changed after sleep loss. The scientists took saliva samples from research participants after they had a normal night's sleep and after they stayed awake for 30 hours. They found two immune genes whose activity levels rose during sleep deprivation.

"Normally we would do additional human experiments to verify these links," Shaw says. "But those studies can be quite expensive, so we thought we'd test the connections in flies first."

The researchers identified genes in the fruit fly that were equivalent to the human genes, but their activity didn't increase when flies lost sleep. When they screened other, similar fruit fly genes, though, the scientists found one that did.

"We've seen this kind of switch happen before as we compared families of fly genes and families of human genes," Shaw says. "Sometimes the gene performing a particular role will change, but the task will still be handled by a gene in the same family."

When the scientists looked for the human version of the newly identified fly marker for sleep deprivation, they found ITGA5 and realized it hadn't been among the human immune genes they screened at the start of the study. Testing ITGA5 activity in the saliva samples revealed that its activity levels increased during sleep deprivation.

"We will need more time to figure out how useful this particular marker will be for detecting sleep deprivation in humans," Shaw says. "In the meantime, we're going to continue jumping between our flies and humans to maximize our insights."


'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Related medicine news :

1. Unusual suspect: Hopkins scientists find second fiddle proteins role in Type 2 diabetes
2. Abnormal gene product associated with prostate cancer generated by unusual mechanism
3. Unusual protein helps regulate key cell communication pathway
4. Premier Provider of Hearing Aids in Santa Monica CA, American Hearing & Balance, Announces New Hearing Aid Comparison Chart
5. The Hearing Center of Lake Charles, Number One Provider of Hearing Aids in Lake Charles LA, Announces New Comparison Guide
6. The cost of prescription drugs -- a comparison of 2 countries
7. Comparison of Obesity Surgeries Turns Up Surprising Results
8. A comparison of 2 home exercises to treat vertigo
9. Sleep duration associated with higher colorectal cancer risk
10. Affordable Acupuncture Practice Helps South Florida Residents Relieve Pain, Sleep Better, Reduce Stress and More
11. Sleep Apnea is a Worldwide Epidemic: Better Rest Solutions Helps Spread Awareness on Sleep Apnea Awareness Day
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... February 24, 2017 , ... ... again hosted their Military Wedding Giveaway, with the winning couple announced on Feb. ... with services generously donated from local vendors: A Matter of Taste, Ryan Rousseau ...
(Date:2/23/2017)... ... February 23, 2017 , ... On February 22, 2017 ... letter to withdraw previous guidance issued by the Obama Administration requiring schools ... in May 2016 by the Obama Administration came in response to a growing ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... to funding innovative lymphoma research and serving the lymphoma community through a comprehensive ... the La Gorce Country Club in Miami Beach to host its Swirl: Miami ...
(Date:2/23/2017)... ... February 23, 2017 , ... The American Cleft Palate-Craniofacial Association (ACPA) ... Meeting. KLS is a longtime supporter of the event. , "We are pleased ... Sponsor," said Dr. Bob Havlik, 2017 ACPA President. "KLS Martin has a long track ...
(Date:2/23/2017)... ... ... Hamlin Dental Group and Dr. Hamid Reza, dentist in North Hollywood ... of February, patients who visit Hamlin Dental Group will receive a ticket for a ... the Cheesecake Factory. , Tickets are available for routine dental visits and other ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... DUBLIN , Feb. 24, 2017 Research ... Health Market Analysis & Trends - Industry Forecast to 2025" ... ... at a CAGR of around 23.8% over the next decade to ... analyzes the market estimates and forecasts for all the given segments ...
(Date:2/24/2017)... 24, 2017 Research and Markets has announced the ... 2016" report to their offering. ... The latest research Dry eye Drugs Price Analysis and Strategies ... eye market. The research answers the following questions: ... their clinical attributes? How are they positioned in the Global Dry eye ...
(Date:2/24/2017)... 2017 Juan Monteverde , founder and ... a boutique securities firm headquartered at the Empire State ... announces that a class action lawsuit has been filed in ...  against Inotek Pharmaceuticals Corporation (NASDAQ:  ITEK)("Inotek" or the "Company") ... 23, 2015 and December 30, 2016, inclusive (the "Class ...
Breaking Medicine Technology: