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Unusual chromosomal changes increase the risk of schizophrenia
Date:7/31/2008

People with schizophrenia have an increased number of unusual chromosomal changes, particularly structural changes that have the potential to alter the function of the genes. These results were published today in the scientific journal Nature.

Research scientists found changes in the structure of the genes in patients with schizophrenia when they studied what are known as copy number variants. Genetic diseases are caused by a large number of different possible changes in human DNA. The type of mutation or change referred to as CNV means that large pieces of DNA may exist in several copies, have disappeared or have been transposed. In some diseases such changes in the genome may be protective, for example in HIV infection and malaria.

"The results strongly support the notion that schizophrenia may be partly caused by the effects of such structural changes in genes, both across the whole genome and in specific chromosomes," says Christina Hultman, associate professor at Karolinska Institutet.

A breakthrough in genetic research on diabetes and prostate cancer, among other diseases, has been achieved in 2007 and 2008 by mapping the whole genome in what are known as genomwide association studies. There is now much to suggest that a breakthrough may also be made in schizophrenia in 2008, when up to seven studies relating to a total of 20,000 cases have been carried out. An important step will then be to understand the biological mechanisms underlying a complex pattern of genes that can be linked to schizophrenia and also what is known as epigenetics, that is to say how genes are switched on and off during the lifespan.

"We anticipate a breakthrough in the near future in research into psychiatric diseases such as schizophrenia, bipolar disease and autism. At the same I wish to stress that in such a complex disease as schizophrenia there is a need for research on both genetic and environmental causes and on treatment and ma
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Contact: Sabina Bossi
sabina.bossi@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

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