Navigation Links
Untangling the mysteries of Alzheimer's
Date:2/2/2012

One of the most distinctive signs of the development of Alzheimer's disease is a change in the behavior of a protein that neuroscientists call tau. In normal brains, tau is present in individual units essential to neuron health. In the cells of Alzheimer's brains, by contrast, tau proteins aggregate into twisted structures known as "neurofibrillary tangles." These tangles are considered a hallmark of the disease, but their precise role in Alzheimer's pathology has long been a point of contention among researchers.

Now, University of Texas Medical Branch at Galveston researchers have found new evidence that confirms the significance of tau to Alzheimer's. Instead of focusing on tangles, however, their work highlights the intermediary steps between a single tau protein unit and a neurofibrillary tangle assemblages of two, three, four, or more tau proteins known as "oligomers," which they believe are the most toxic entities in Alzheimer's.

"What we discovered is that there are smaller structures that form before the neurofibrillary tangles, and they are much more toxic than the big structures," said Rakez Kayed, UTMB assistant professor and senior author of a paper on the work now online in the FASEB Journal. "And we established that they were toxic in real human brains, which is important to developing an effective therapy."

According to Kayed, a key antibody developed at UTMB called T22 enabled the team to produce a detailed portrait of tau oligomer behavior in human brain tissue. Specifically designed to bond only to tau oligomers (and not lone tau proteins or neurofibrillary tangles), the antibody made it possible for the researchers to use a variety of analytical tools to compare samples of Alzheimer's brain with samples of age-matched healthy brain.

"One thing that's remarkable about this research is that before we developed this antibody, people couldn't even see tau oligomers in the brain," Kayed said. "With T22, we were able to thoroughly characterize them, and also study them in human brain cells."

Among the researchers' most striking findings: in some of the Alzheimer's brains they examined, tau oligomer levels were as much as four times as high as those found in age-matched control brains.

Other experiments revealed specific biochemical behavior and structures taken on by oligomers, and demonstrated their presence outside neurons in particular, on the walls of blood vessels.

"We think this is going to make a big impact scientifically, because it opens up a lot of new areas to study," Kayed said. "It also relates to our main focus, developing a cure for Alzheimer's. And I find that very, very exciting."


'/>"/>
Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. Unusual Place to Find Peace, Bliss and Explore Life's Mysteries
2. Scientists Unravel Mysteries of Intelligence
3. Secrets to Life, the Shroud of Turin, and Heaven's Mysteries Revealed
4. Man Receives Miracle – Able to Solve the Dead Sea Scrolls, Shroud of Turin, and Mysteries to Heaven
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... , ... May 22, 2017 , ... ... is now welcoming new patients with periodontal plastic surgery treatments, including crown ... general dentist. Dr. Green provides these esthetic and functional procedures to help patients ...
(Date:5/22/2017)... ... ... Faithfully following pop culture, people today are forever in pursuit of physical ... programs. It carries on to skin nourished, pampered and nurtured to be soft and ... CDA has found that just like a perfectly cut and polished diamond, that ...
(Date:5/21/2017)... , ... May 20, 2017 , ... ... systems between ABC Financial Services and financial systems. , Dozens of ... exported files that are electronically processed through GetLinked into their club’s accounting system ...
(Date:5/21/2017)... ... ... For more than 20 years United Cutlery has been distinguished by unique ... functional to fantasy. United Cutlery has always been “Stronger. Sharper” than the competition and ... Offering a range of weapons and tools built for battle, the M48 line by ...
(Date:5/19/2017)... (PRWEB) , ... May 19, 2017 , ... ... RawTrition’s BioEnergy in an upcoming episode of Innovations with Ed Begley, Jr., airing ... RawTrition is the distributor of a clean, organic dietary supplement made from naturally ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... 5, 2017  May is Stroke Awareness Month and ... most important methods to prevent a stroke: monitor and ... Disease Control and Prevention, undetected and uncontrolled hypertension is ... the global leader in personal heart health technology, recently ... heart attack and stroke and is advancing a national ...
(Date:5/4/2017)... and SAN DIEGO , May ... Gynecologists (ACOG) 2017 Annual Clinical and Scientific Meeting— OBP ... illuminating medical devices, today announced the launch of a ... OfficeSPEC and ER-SPEC vaginal specula. ... of extra-small and extra-large sizes makes OBP Medical,s line ...
(Date:5/3/2017)... ROCKVILLE, Md. , May 3, 2017 /PRNewswire/ ... revenue growth of nine percent next year and ... solid organ and hematopoietic stem cell (HSCT) or ... and donor. Molecular testing technologies are well-suited for this ... healthcare-only market research publisher Kalorama Information. The various ...
Breaking Medicine Technology: