Navigation Links
Unstable chromosomes linked to less favorable response to RT and surgery in prostate cancer patients
Date:9/25/2013

Atlanta, September 25, 2013 -- Detailed evaluation of a prostate cancer tumor biopsy may predict treatment outcomes for image-guided radiation therapy (IGRT) or surgery for prostate cancer, according to research presented today at the American Society for Radiation Oncology's (ASTRO's) 55th Annual Meeting. The study results indicate that patients who have abnormal levels of breaks at common fragile sites (CFSs), sites within the chromosomes that are sensitive to DNA damage, are more likely to have their cancer to return -- treatment failure. These CFS break abnormalities are usually associated with instability of the cell's DNA, a phenomenon that is particularly associated with cancer.

In this study, researchers assessed the outcomes of 280 prostate cancer (Cap) patients, and reviewed the DNA "fingerprints" of each patient's tumor (using the patient's initial diagnostic core biopsy) to determine if gene copy number alterations (CNAs), or breaks in CFSs, were related to a less positive response to treatment. Two groups were analyzed: 126 localized intermediate risk CaP patients who had received image-guided radiation therapy (IGRT) treatments, with a mean dose of 74.6 Gy; and 154 localized intermediate and high risk CaP patients who had undergone radical prostatectomy (RP), which is the surgical removal of the entire prostate gland.

Utilizing an array comparative genomic hybridization (aCGH), DNA from frozen needle biopsies of the RT patients was analyzed for 13 previously characterized CFSs: FRA2G, FRA3B, FRA4F, FRA6E, FRA6F, FRA7E, FRA7G, FRA7H, FRA7I, FRA7K, FRA8C, FRA9E, FRA16D. The effect of having at least one CNA in any CFS was assessed using the Kaplan-Meier method and Cox proportional hazard models.

The data revealed a pattern in which the patients who failed treatment had abnormal levels of CNAs at CFSs. In the IGRT group, CNAs in CFSs occurred frequently, with 80 of the patients (64 percent) having a CNA in one or more CF
'/>"/>

Contact: Michelle Kirkwood
michellek@astro.org
703-286-1600
American Society for Radiation Oncology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Skechers Fracture Lawsuit Filed on Behalf of an Arizona Woman Who Sustained Multiple Arm Fractures Allegedly Due to Unstable Shape-Ups, by Wright & Schulte
2. Dual systems key to keeping chromosomes intact
3. Scientists discover how chromosomes keep their loose ends loose
4. Caloric restriction has a protective effect on chromosomes
5. Warwick scientists uncover how checkpoint proteins bind chromosomes
6. HPV Linked to Growing Number of Young Adults with Oropharyngeal Cancer
7. HPV linked to growing number of young adults with oropharyngeal cancer
8. Casey Gollan’s LinkedIn Tips for Entrepreneurs
9. Fragile X syndrome protein linked to breast cancer progression
10. Cold sore linked to mutation in gene, study suggests
11. Study suggests antioxidant treatment may help NF1-linked behavioral issues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... By Alan Mozes ... 2014 (HealthDay News) -- Colon cancer patients who are ... slightly higher risk for developing a second weight-related cancer, ... to the risk of colon cancer recurrence, only the ... , "We found that colorectal cancer survivors who reported ...
(Date:9/30/2014)... breast cancer is the leading cause of cancer death ... why so many medical professionals encourage women to get ... only a minority of suspicious mammograms actually leads to ... needless worry for women and their familiesnot to mention ... ultrasounds and biopsies. , Recently, a different type ...
(Date:9/30/2014)... CO September 30, 2014 Keystone Symposia will ... the first in its 2014-15 Global Health Series ... the Sheraton Seattle Hotel immediately following the conclusion ... The four-day conference is part of the Keystone Symposia ... Gates Foundation, which has also funded travel awards for ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 A new ... State University studied the impact of stress on metabolism after ... and french fries from a fast food restaurant, about 930 ... resting metabolism for 20 minutes every hour for 7 hours, ... showed that women who had experienced a stressful event in ...
(Date:9/30/2014)... 30, 2014 Integrated Medicine Alliance ... opening another new medical specialty practice through a unique ... will be located within the company’s Shrewsbury location ... Dr. Isaac Tawfik of American Heart Center, P.C., a ... practice will offer Integrated Medicine Alliance patients top notch ...
Breaking Medicine News(10 mins):Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 2Health News:Obesity Tied to Higher Cancer Risk for Colon Cancer Survivors 3Health News:'Virtual breast' could improve cancer detection 2Health News:Keystone Symposia launches 2014-2015 meeting series with Global Health Vaccines Conference 2Health News:NutriGold Urges Every Woman To Read a Recent Study About Diet and Stress 2Health News:NutriGold Urges Every Woman To Read a Recent Study About Diet and Stress 3Health News:Integrated Medicine Alliance Announces New Cardiology Practice 2
... 9 According to Millennium Research Group (MRG), the ... economic crisis is putting pressure on publicly-funded health care ... (IC) device prices in the region. MRG,s ... (Part II) report details the extent to which ...
... ... world,s leading manufacturer and distributor of automated blood pressure monitors and health testing stations, ... ... -- Lifeclinic International has named Lon von Hurwitz Executive Vice President of ...
... July 9 Life Spine announced today that the ... marketing clearance to the FS3 Minimally Invasive Spinal System. ... the FS3 MIS Spinal System offers cannulated wire guided ... range of patient pathologies through a percutaneous or open ...
... Researchers suspect estrogen levels play a part in the connection , ... migraines, here,s a bit of good news: New research shows that ... as 26 percent. , And, no matter what a woman,s age ... of breast cancer is still reduced, according to the study, which ...
... NEW YORK, July 9 Thousands of ... to remain financially afloat. Some are forced to,choose between ... and medications, are being sacrificed and the results can ... difference between,staying healthy and developing a debilitating disease. The ...
... , SARASOTA, Fla., July 9 There,s a new company ... feel trapped - and it is carrying out this ... of products ranging from power wheelchairs and portable oxygen, to ... mobility to people who have trouble getting around. , ...
Cached Medicine News:Health News:European Health Care Institutions Forced to Select Lower-Priced Interventional Cardiology Devices 2Health News:Pioneer of Digital Place-Based Media Joins World's Leading Blood Pressure and Health Kiosk Manufacturer 2Health News:Migraines Linked to Reduced Breast Cancer Risk 2Health News:Keep Healthy in a Poor Economy 2Health News:Keep Healthy in a Poor Economy 3
(Date:9/30/2014)... LONDON , Sept. 30, 2014 This report ... Million by the following Product Categories: Enteral Feeding Pumps, Nasogastric ... analytics for the US Canada, Japan , ... Latin America , and Rest of World. ... through 2018. Also, a six-year historic analysis is provided for ...
(Date:9/30/2014)... 2014  Hologic, Inc. (NASDAQ: HOLX ), ... and Chief Executive Officer, will preside over the NASDAQ ... first day of Breast Cancer Awareness Month. In his ... on the important benefits of Hologic,s 3D Mammography technology, ... clinically superior to traditional mammography. This is ...
(Date:9/30/2014)... , Sept. 30, 2014  Tasly Pharmaceuticals, ... to modernize medicine, announced today the launch of ... nutraceuticals developed to address men and women concerned ... and vibrant into old age while helping keep ... three condition-specific, whole-food and herb-based formulas, namely, ProHeart ...
Breaking Medicine Technology:Global Enteral Feeding Devices Industry 2Global Enteral Feeding Devices Industry 3Global Enteral Feeding Devices Industry 4Global Enteral Feeding Devices Industry 5Global Enteral Feeding Devices Industry 6Global Enteral Feeding Devices Industry 7Global Enteral Feeding Devices Industry 8Global Enteral Feeding Devices Industry 9Global Enteral Feeding Devices Industry 10Global Enteral Feeding Devices Industry 11Global Enteral Feeding Devices Industry 12Global Enteral Feeding Devices Industry 13Global Enteral Feeding Devices Industry 14Global Enteral Feeding Devices Industry 15Global Enteral Feeding Devices Industry 16Global Enteral Feeding Devices Industry 17Global Enteral Feeding Devices Industry 18Global Enteral Feeding Devices Industry 19Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 2Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 3
... LYON, France, Oct. 9 Vical Incorporated,(Nasdaq: ... study in mice demonstrated,the potential of its patented ... with a protein-based H5N1 pandemic influenza vaccine,currently stockpiled ... in extending limited vaccine supplies to protect the ...
... - A Total of 13 Abstracts for Eight Compounds Being ... on October 24, 2007 at 6:00 PM PDT -, ... EXEL ) today announced that data from ongoing phase 2 ... non-small cell,lung cancer, respectively, will be presented at the 2007 ...
Cached Medicine Technology:Vical Demonstrates Dose-sparing of Protein-based H5N1 Influenza Vaccine With Vaxfectin(TM) Adjuvant 2Vical Demonstrates Dose-sparing of Protein-based H5N1 Influenza Vaccine With Vaxfectin(TM) Adjuvant 3Vical Demonstrates Dose-sparing of Protein-based H5N1 Influenza Vaccine With Vaxfectin(TM) Adjuvant 4New Data for XL880, XL647 and XL184 to Be Presented at AACR-NCI-EORTC 2New Data for XL880, XL647 and XL184 to Be Presented at AACR-NCI-EORTC 3
The STAAR ELASTIC LENS®, is a single piece silicone lens to be placed completely in the capsular bag....
... Lomb SoFlex™ UV-Absorbing, Silicone Posterior ... to be used for primary ... of aphakia in patients 60 ... where a cataractous lens has ...
Liberty Three Piece PMMA Lens with UV Absorber....
Single piece Anterior Chamber PMMA lens, AC depth: 4.9....
Medicine Products: