Navigation Links
Unsaturated fat breakdown leads to complications of acute pancreatitis in obese patients
Date:11/2/2011

PITTSBURGH -- The toxic byproducts produced by the breakdown of unsaturated fats lead to a higher likelihood of severe inflammation, cell death and multi-system organ failure among acute pancreatitis patients who are obese, say researchers at the University of Pittsburgh School of Medicine. Their findings, published online today in Science Translational Medicine, provide new insight into how fat can induce complications after sudden inflammatory, non-infectious illnesses.

Doctors have observed that obese people are at greater risk for adverse outcomes after trauma, severe burns, critical illnesses and acute pancreatitis, which is an inflammatory condition of the pancreas typically brought on by gallstones and alcohol, said senior author and UPMC gastroenterologist Vijay Singh, M.D., assistant professor, Division of Gastroenterology, Hepatology and Nutrition, Pitt School of Medicine.

"The mortality rate among patients with severe acute pancreatitis is 40 to 50 percent when kidney failure and respiratory failure develop," he said. "Our findings indicate that the breakdown of unsaturated fat in acute inflammatory conditions can lead to tissue damage throughout the body."

Dr. Singh's team examined pancreas tissue from 24 patients who died with acute pancreatitis and compared them to 50 people who died of other causes. They found that the diseased pancreases of patients who were obese, meaning a body mass index equal to or greater than 30, contained more fat cells, and confirmed the presence of fat from CT imaging scans from the patients taken before their deaths. Autopsy tissue showed also that there was more pancreatic cell death in the areas around fat cell destruction.

Pancreatic fluids from six obese patients with severe acute pancreatitis who had surgical procedures to remove dead tissue revealed high amounts of unsaturated fatty acids, produced from the breakdown of unsaturated fat, than saturated fatty acids. When
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Adding monounsaturated fats to a low-cholesterol diet can further improve levels
2. Adding Monounsaturated Fats to Diet May Boost Heart Health
3. Polyunsaturated Fats Really May Lower Heart Risk
4. Step in breakdown of HIV proteins essential to recognition, destruction of infected cells
5. ASU leads $5 million NIH-sponsored research initiative to advance diabetes care and treatment
6. Rise in Vulvar Precancers Leads to New Guidelines
7. Project leads next decade of aging research across Europe
8. Project leads next decade of ageing research across Europe
9. X-ray protein probe leads to potential anticancer tactic
10. Insulation from public pressure leads to more accurate suicide reporting by death investigators
11. Unconventional hunt for new cancer targets leads to a powerful drug candidate for leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... 2014 Jeremiah’s Tavern ... wood to create a unique atmosphere and highlight ... features reclaimed barn siding on the ... mixed softwoods flowing throughout the interior as flooring. ... sister company New Energy Works Timberframers ...
(Date:7/31/2014)... 31, 2014 US Hair Restoration Founder, Dr. ... be known as Parsa Mohebi Hair Restoration. Since first ... patients in Southern California and around the world, who traveled ... and Orange County. These patients achieved the full benefits of ... that were perfected by Dr. Mohebi. They have come ...
(Date:7/31/2014)... Ce-Classes.com has developed a Learning Management ... to pass inspections and audits. Ce-Classes.com can ... accreditation and state licensing criteria by providing their ... administrators can monitor employee compliance with mandatory training ... can be developed based on the policies and ...
(Date:7/31/2014)... 31, 2014 Current residents at ... program in Flagstaff, AZ, learn to kayak safely for ... and paddle strokes in preparation for next week's wilderness ... think that [the kayaking course] teaches [residents] to listen ... with in their early part of their sobriety," said ...
(Date:7/31/2014)... 31, 2014 Located on one of the ... The Rothenberg Law Firm LLP has moved its office to ... The Rothenberg Law Firm has been handling catastrophic personal injury ... by growth in the firm’s continued success in seeking justice ... York office has a team of experienced and successful trial ...
Breaking Medicine News(10 mins):Health News:Popular Tavern Restaurant Features Pioneer Millworks’ Reclaimed Wood in New Locations 2Health News:US Hair Restoration Becomes Parsa Mohebi Hair Restoration 2Health News:Company Helps Healthcare Agencies to Pass Inspections and Audits 2Health News:Company Helps Healthcare Agencies to Pass Inspections and Audits 3Health News:Back2Basics Substance Abuse Residents Take Kayaking Class for the First Time 2
... Group to Release Groundbreaking Study on Economic Impact of Life ... State SEATTLE, April 20 An alliance ... launch "We Work for Health," a landmark statewide effort to ... life sciences industry and to promote the growth and success ...
... 20 Stryker Corporation (NYSE: SYK ) reported operating ... Quarter Highlights , , ... basis (2.0% decrease as reported) to $1,601 million , ... constant currency basis (0.2% increase as reported) , ...
... common thread among all 3 conditions , , MONDAY, April ... credence to a long-suspected connection between psoriasis, diabetes and ... the Archives of Dermatology suspect the link ... is associated with all three conditions. , "We were ...
... need to make very difficult choices, such as deciding to ... in the Journal of Consumer Research delves into ... or doctors to make those "tragic choices." , Authors ... Iyengar (both Columbia University) say that from the time of ...
... HCA today announced the recipients of the ... a Physician Assistant at Wesley Medical Center in ... Northside Hospital in Macon, Ga., and Laurence Lesser, ... Center in Snellville. Ga., were honored today during ...
... WASHINGTON, April 20 In a recent study, ... blood into cells that are molecularly and functionally ... that provides a readily accessible source of stem ... cells. The findings were prepublished online in ...
Cached Medicine News:Health News:Life Sciences Leaders to Launch Statewide 'We Work for Health' Economic Development and Jobs Campaign 2Health News:Stryker Operating Results for Quarter Ended March 31, 2009 2Health News:Stryker Operating Results for Quarter Ended March 31, 2009 3Health News:Stryker Operating Results for Quarter Ended March 31, 2009 4Health News:Stryker Operating Results for Quarter Ended March 31, 2009 5Health News:Stryker Operating Results for Quarter Ended March 31, 2009 6Health News:Stryker Operating Results for Quarter Ended March 31, 2009 7Health News:Stryker Operating Results for Quarter Ended March 31, 2009 8Health News:Having Psoriasis Raises Risk of Diabetes, Hypertension 2Health News:Tragic choices: Is it better for doctors or patient families to decide? 2Health News:HCA Announces National 2008 Frist Humanitarian Award Recipients 2Health News:HCA Announces National 2008 Frist Humanitarian Award Recipients 3Health News:Study Finds Blood Cells Can Be Reprogrammed to Act as Embryonic Stem Cells 2Health News:Study Finds Blood Cells Can Be Reprogrammed to Act as Embryonic Stem Cells 3
(Date:7/31/2014)... For its innovative modular Biomedical Research building ... Scientific has earned a Modular Building Institute (MBI) 2014 ... 30 categories, MBI,s contest is the commercial modular industry,s ... manufacturers, dealers, and product and service providers. ... of our team," said Dan Palmer , President ...
(Date:7/31/2014)... VIENNA , July 31, 2014 ... in New York results of AFF008, ... Parkinson,s disease. PD01A is the first therapy against the protein ... The Michael J. Fox Foundation for Parkinson,s Research ... and presented at the press conference on the impact a ...
(Date:7/31/2014)... For the first time, cardiac surgeons, medical ... the SynCardia temporary Total Artificial Heart in a peer ... the Journal of Visualized Experiments website. ... the SynCardia Total Artificial Heart implantation   goo.gl/2OZyKW ... the SynCardia Total Artificial Heart," a July 18, 2014 ...
Breaking Medicine Technology:Art's Way Scientific Earns Prestigious Modular Building Institute Award 2Art's Way Scientific Earns Prestigious Modular Building Institute Award 3Art's Way Scientific Earns Prestigious Modular Building Institute Award 4First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 2First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 3First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 4How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 2How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video 3
... JOSE, Calif., June 13, 2011 SI-BONE, Inc. (San Jose, ... of a minimally invasive surgical (MIS) device to treat the ... surgeon training milestone for its iFuse Implant System® with over ... in Europe.  As a result, the medical community,s awareness of ...
... MIAMI, June 13, 2011 Sanomedics International Holdings, Inc. (Pink ... Chairman, with Keith Houlihan, Co-founder and President of Sanomedics ... appointment of Charlie Alvarez, Co-founder and President of Watermark ... "The addition of Charlie to the Sanomedics ...
Cached Medicine Technology:Over 400 Surgeons Trained by SI-BONE to Perform Minimally Invasive iFuse Sacroiliac Joint Fusion 2Over 400 Surgeons Trained by SI-BONE to Perform Minimally Invasive iFuse Sacroiliac Joint Fusion 3Over 400 Surgeons Trained by SI-BONE to Perform Minimally Invasive iFuse Sacroiliac Joint Fusion 4Mr. Charlie Alvarez Joins the Board of Sanomedics International Holdings, Inc. 2Mr. Charlie Alvarez Joins the Board of Sanomedics International Holdings, Inc. 3
... absolute knowledge. Access it with ... Diagnostic Workstation, uniting two trusted ... and Orbscan IIz Anterior Segment ... critically important data. Together they ...
... LADARWave® device gives you ... measure and display the ... individual eye. This capability ... a better understanding of ...
ZYMAR™ ophthalmic solution is an anti-infective prescription eye drop that your doctor may instruct you to use if you have an eye infection caused by bacteria. Bacterial conjunctivitis is the e...
...
Medicine Products: