Navigation Links
Unsaturated fat breakdown leads to complications of acute pancreatitis in obese patients
Date:11/2/2011

PITTSBURGH -- The toxic byproducts produced by the breakdown of unsaturated fats lead to a higher likelihood of severe inflammation, cell death and multi-system organ failure among acute pancreatitis patients who are obese, say researchers at the University of Pittsburgh School of Medicine. Their findings, published online today in Science Translational Medicine, provide new insight into how fat can induce complications after sudden inflammatory, non-infectious illnesses.

Doctors have observed that obese people are at greater risk for adverse outcomes after trauma, severe burns, critical illnesses and acute pancreatitis, which is an inflammatory condition of the pancreas typically brought on by gallstones and alcohol, said senior author and UPMC gastroenterologist Vijay Singh, M.D., assistant professor, Division of Gastroenterology, Hepatology and Nutrition, Pitt School of Medicine.

"The mortality rate among patients with severe acute pancreatitis is 40 to 50 percent when kidney failure and respiratory failure develop," he said. "Our findings indicate that the breakdown of unsaturated fat in acute inflammatory conditions can lead to tissue damage throughout the body."

Dr. Singh's team examined pancreas tissue from 24 patients who died with acute pancreatitis and compared them to 50 people who died of other causes. They found that the diseased pancreases of patients who were obese, meaning a body mass index equal to or greater than 30, contained more fat cells, and confirmed the presence of fat from CT imaging scans from the patients taken before their deaths. Autopsy tissue showed also that there was more pancreatic cell death in the areas around fat cell destruction.

Pancreatic fluids from six obese patients with severe acute pancreatitis who had surgical procedures to remove dead tissue revealed high amounts of unsaturated fatty acids, produced from the breakdown of unsaturated fat, than saturated fatty acids. When the researchers combined healthy pancreatic cells with the unsaturated fatty acids in a test tube, the pancreatic cells died.

Then, they induced pancreatitis in obese mice and found that like the human patients, they had high amounts of fat in their pancreases. The fat in obese mice was mostly unsaturated. Kidneys of the mice with pancreatitis were damaged and contained fat deposits, an unexpected finding supported by studies in human autopsy tissue. Infusing unsaturated fatty acids into the bloodstream of the animals leads to lung injury akin to the problems seen in human patients, while administration of saturated fatty acids does not.

"Now that we better understand why these complications arise, we might be able to prevent them and reduce deaths," Dr. Singh said. "We must find ways to stop this toxic process from happening."

He and his team are studying ways to prevent the generation of unsaturated fatty acids in obese rodents to see what happens when they develop acute pancreatitis.


'/>"/>
Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Related medicine news :

1. Adding monounsaturated fats to a low-cholesterol diet can further improve levels
2. Adding Monounsaturated Fats to Diet May Boost Heart Health
3. Polyunsaturated Fats Really May Lower Heart Risk
4. Step in breakdown of HIV proteins essential to recognition, destruction of infected cells
5. ASU leads $5 million NIH-sponsored research initiative to advance diabetes care and treatment
6. Rise in Vulvar Precancers Leads to New Guidelines
7. Project leads next decade of aging research across Europe
8. Project leads next decade of ageing research across Europe
9. X-ray protein probe leads to potential anticancer tactic
10. Insulation from public pressure leads to more accurate suicide reporting by death investigators
11. Unconventional hunt for new cancer targets leads to a powerful drug candidate for leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... 25, 2016 , ... Today Omega Institute, a leading destination for yoga education ... training opportunities in the growing field of yoga therapy . Yoga therapy ... with specific health issues—including injuries, illnesses, and temporary or chronic health conditions. , “Yoga ...
(Date:5/25/2016)... ... May 25, 2016 , ... DKT International, one ... developing world, is pleased to release their 2015 global impact data. In 2015, ... almost 14,000 maternal deaths and 3.8 million unsafe abortions across 21 countries worldwide. ...
(Date:5/25/2016)... Coral Gables, FL (PRWEB) , ... May 25, ... ... in its Cross Benefit Clearinghouse supporting the real time adjudication of medical service ... Urgent Care providers using their current medical claims management software. The TransactRx Cross ...
(Date:5/25/2016)... SAN FRANCISCO, CA (PRWEB) , ... May 25, 2016 , ... ... the School of Nursing and Health Professions. She will lead a team of more ... Leadership Team. Baker will begin her role as dean in late August. , Baker ...
(Date:5/25/2016)... ... May 25, 2016 , ... Laser Skin & ... turn back the hands of time of female aging. The Juliet™ ... Women with symptoms such as leakage, laxity, itchiness and pain have reported real relief ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... Mass. , May 24, 2016  NxStage Medical, ... technology company focused on advancing renal care, today announced ... plans to participate in the following schedule of investor ... be made available at http://ir.nxstage.com/ . ... Jefferies Healthcare Conference NY, NY           Friday, June ...
(Date:5/24/2016)... HONG KONG , May 24, 2016 /PRNewswire/ ... primer stent de doble terapia del mundo, introduce ... fístula arteriovenosa. OrbusNeich, una compañía global ... cambian las vidas, ha expandido su cartera incluyendo ... catéteres balón JADE™ y Scoreflex™ PTA son los ...
(Date:5/24/2016)... AMSTERDAM , May 24, 2016 ... met elkaar verbindt, zodat zij collectief patiënten kunnen behandelen, ... Dat is het idee achter de nieuwe en revolutionaire ... aanvoering van de Nederlandse vaatchirurg dr. Hans Flu en ... MDLinking app, die inmiddels beschikbaar is, wordt op dinsdag ...
Breaking Medicine Technology: