Navigation Links
Unsaturated fat breakdown leads to complications of acute pancreatitis in obese patients
Date:11/2/2011

PITTSBURGH -- The toxic byproducts produced by the breakdown of unsaturated fats lead to a higher likelihood of severe inflammation, cell death and multi-system organ failure among acute pancreatitis patients who are obese, say researchers at the University of Pittsburgh School of Medicine. Their findings, published online today in Science Translational Medicine, provide new insight into how fat can induce complications after sudden inflammatory, non-infectious illnesses.

Doctors have observed that obese people are at greater risk for adverse outcomes after trauma, severe burns, critical illnesses and acute pancreatitis, which is an inflammatory condition of the pancreas typically brought on by gallstones and alcohol, said senior author and UPMC gastroenterologist Vijay Singh, M.D., assistant professor, Division of Gastroenterology, Hepatology and Nutrition, Pitt School of Medicine.

"The mortality rate among patients with severe acute pancreatitis is 40 to 50 percent when kidney failure and respiratory failure develop," he said. "Our findings indicate that the breakdown of unsaturated fat in acute inflammatory conditions can lead to tissue damage throughout the body."

Dr. Singh's team examined pancreas tissue from 24 patients who died with acute pancreatitis and compared them to 50 people who died of other causes. They found that the diseased pancreases of patients who were obese, meaning a body mass index equal to or greater than 30, contained more fat cells, and confirmed the presence of fat from CT imaging scans from the patients taken before their deaths. Autopsy tissue showed also that there was more pancreatic cell death in the areas around fat cell destruction.

Pancreatic fluids from six obese patients with severe acute pancreatitis who had surgical procedures to remove dead tissue revealed high amounts of unsaturated fatty acids, produced from the breakdown of unsaturated fat, than saturated fatty acids. When
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Adding monounsaturated fats to a low-cholesterol diet can further improve levels
2. Adding Monounsaturated Fats to Diet May Boost Heart Health
3. Polyunsaturated Fats Really May Lower Heart Risk
4. Step in breakdown of HIV proteins essential to recognition, destruction of infected cells
5. ASU leads $5 million NIH-sponsored research initiative to advance diabetes care and treatment
6. Rise in Vulvar Precancers Leads to New Guidelines
7. Project leads next decade of aging research across Europe
8. Project leads next decade of ageing research across Europe
9. X-ray protein probe leads to potential anticancer tactic
10. Insulation from public pressure leads to more accurate suicide reporting by death investigators
11. Unconventional hunt for new cancer targets leads to a powerful drug candidate for leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... California (PRWEB) April 24, 2015 Ryadon ... a wide range of capabilities and services to complement ... , Ryadon's Quantity Discount Program will be offered on ... follows: , Order 4-19: Receive 10% discount - Order ... by Using the Drawer Slides Products, ...
(Date:4/24/2015)... New York, New York (PRWEB) April 24, 2015 ... continue to move forward in the federal ... of South Carolina. According to court documents, the ... Status Report on April 16th detailing, among other ... The report notes that counsel for both plaintiffs ...
(Date:4/24/2015)... The first step to transforming one’s life is ... and yoga teacher Stine Koppernæs, meditation and changing the ... allow her to experience more peace and freedom from ... since 2006, and through the years she has experienced ... “I love sharing this way of finding true, lasting ...
(Date:4/24/2015)... Anchor Health Administrators (Anchor), specialists in Long-Term Care ... exclusive agreement with LTC Solutions for All LLC (SFA) ... , Anchor has more than 18 years of experience ... and is currently the designated advocate for the American ... member benefit. , “I am very pleased to be ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 “Kind,” “selfless,” ... were among the ways Denise Weiner described pediatric oncology ... cared for her daughter, Alexa, during her five-year battle ... resections, a bone marrow transplant and numerous experimental treatments, ... to visit Alexa when she was not in the ...
Breaking Medicine News(10 mins):Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3Health News:Federal Lipitor Lawsuits Progress, as New Status Report Details Preparation for Upcoming Bellwether Trials 2Health News:Federal Lipitor Lawsuits Progress, as New Status Report Details Preparation for Upcoming Bellwether Trials 3Health News:CURE™ Magazine Names Pediatric Nurse Laura Vasquez from Children’s Hospital Los Angeles As Extraordinary Healer™ of 2015 2Health News:CURE™ Magazine Names Pediatric Nurse Laura Vasquez from Children’s Hospital Los Angeles As Extraordinary Healer™ of 2015 3Health News:CURE™ Magazine Names Pediatric Nurse Laura Vasquez from Children’s Hospital Los Angeles As Extraordinary Healer™ of 2015 4
... it is that can induce maximum learning amongst the ... revealed that toddlers learn the maximum when they watch ... with. ,The researchers conducted two experiments to ... the first, they tested differences in learning from video ...
... economy class syndrome, that is associated with the formation of ... cabin environment, //as it is thought to be, reveals a ... could form in healthy people, while sitting in cramped places, ... legs, which lead to the formation of clots. This is ...
... According to a new study it was found that ... of age or above, their mental abilities are on ... //Presented in New York City at the 21st Annual ... 2006), the study measured blood pressure and cognitive function ...
... American Journal of Respiratory and Critical Care Medicine says that ... in lung capacity equivalent to what usually happens after 12 ... ,An average loss of 372 milliliters was noted, which ... loss is at least 10 times more than the annual ...
... new study that has thrown light on allergic reactions in ... who get bitten by insects are in need of medical ... any adverse allergic symptoms. ,The study, entitled “Allergic reactions to ... high school children in Israel” can be found in the ...
... Chapel Hill it is very much essential for the expression of ... eye. // Neural stem cells are totipotent cells and can differentiate ... gene is expressed properly then it results in the formation of ... Larysa H. Pevny, an assistant professor of genetics in the UNC ...
Cached Medicine News:Health News:Interactive Video, Better Teaching Aid For Toddlers 2Health News:As You Age Check Your BP for It Can Affect Your Mental Ability 2Health News:Insect Bites Among Children Do Not Warrant Medical Attention In Most Cases 2Health News:Importance of Gene in Eye Development 2
(Date:4/24/2015)... -- Boston Scientific Corporation (NYSE: BSX ) is scheduled ... Healthcare Conference on May 6 in Boston ... and chief financial officer, and Susie Lisa , vice ... answer session regarding the company with the host analyst at ... the presentation and question and answer session will be available ...
(Date:4/24/2015)... 2015  Novartis Pharmaceuticals Corporation (NPC) has been named the ... row on the annual DiversityInc Top 50 Companies for Diversity ... Companies for Diversity on April 23 at an awards ceremony ... ranked second on the DiversityInc Top 10 Companies for Recruitment ... Resource Groups list. David Epstein , ...
(Date:4/24/2015)... 2015 /CNW/ - T-Bird Pharma Inc. (TSXV:TPI) ("T-Bird" or ... quality medical marijuana products and a licensed producer ("LP") ... Regulations ( Canada ) ("MMPR"), is pleased ... shareholders, has closed the transaction announced on March 11, ... (the "Escrow Transfer") a total of 20,156,790 common shares ...
Breaking Medicine Technology:Boston Scientific To Participate In The Deutsche Bank 40th Annual Healthcare Conference 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 3Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 4T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 2T-Bird Pharma Inc. Announces Closing of Transaction with Medna Biosciences 3
... 2011 On Wednesday, April 27 at 11 a.m., ... Langevin, Governor Lincoln Chafee, Lieutenant Governor Elizabeth H. Roberts, ... at its headquarters at 211 Circuit Drive in North ... Peter F. Kilmartin will tour Dominion,s laboratory at 1 ...
... JACKSON, Wis., April 25, 2011 Wisconsin Pharmacal Company, ... market recall of Triad Povidone Iodine Prep Pads, manufactured ... names including Triad. The Triad Povidone Iodine Prep Pads ... distributed by Wisconsin Pharmacal Company. In the interest of ...
Cached Medicine Technology:Dominion Diagnostics Celebrates National Medical Laboratory Professionals Week with Rhode Island Elected Officials 2Important Information for Atwater Carey First Aid Kit Consumers Regarding Triad Group's Povidone Iodine Prep Pads 2
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Standard type 1/1 (mm), opening width 9.0 mm and length 6 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Standard type 1/1 (mm), opening width 8.0 mm and length 8 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Standard type 1/1 (mm), opening width 8.0 mm and length 7 mm....
... Signature is a state of the ... integrates blood, sterile body fluid and ... microbiology workstation with comprehensive capabilities. It ... and where expanded flexibility in operating ...
Medicine Products: