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Unraveling kidney cancer
Date:1/6/2010

genetic foundation of ccRCC will ultimately help in diagnosis and in selection of treatment: the data show that, on the basis of genetic lesions, even apparently homogeneous cancers can be begin to be classified into subtypes that display distinctive biological features driven by specific mutations.

There has been some success in exploiting one driver mutation in ccRCC, VHL, in therapeutic approaches the most productive means to discover new biological understanding of this enigmatic cancer has been genetics and more will be needed.

"Even in a tumour type dominated by single histology, with a prevalent signature, even in this 'clearest' of cases, we see evidence for substantial genetic heterogeneity," explains Dr Futreal. "In this large set of 100 ccRCC samples, some mutations are found only once or twice and so we are likely to have missed others.

"To search comprehensively to build the full picture we need of cancer genetics we will need many hundred samples sequenced through the entire genome and all genes. The target for those cancers being analysed by the International Cancer Genome Consortium is 500. This is the scale that will be required to really take this group of diseases apart."


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Contact: Don Powell
press.officer@sanger.ac.uk
44-122-349-6928
Wellcome Trust Sanger Institute
Source:Eurekalert  

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