Navigation Links
Unraveling kidney cancer
Date:1/6/2010

In a new study, scientists have searched for mutations in the gene regions of more than 100 kidney cancer samples, the largest number of samples from a single tumour type to be sequenced to date.

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, with 102,000 deaths worldwide each year. It is noteworthy because its pathology all the visible clues to its nature is remarkably consistent and the majority of cases are known to be driven, at least in part, by mutations in a single gene, VHL. In this study, the team looked for mutations in 3544 genes in 101 cases of ccRCC to begin to investigate the complexity within this reasonably homogeneous cancer type.

"ccRCC has such a strong genetic signature, with the VHL gene undergoing mutation in more than 50 per cent of samples," explains Dr Andy Futreal, co-leader of the Cancer Genome Project at the Wellcome Trust Sanger Institute. "It also has a strong pathological signature, with a homogeneous appearance in most cases.

"We also know that there are very few examples of known 'cancer genes' being mutated in ccRCC, making it a very interesting tumour to explore the contribution of novel genes in human cancer and thus provide opportunities to more fully understand the processes that can be subverted to drive cancer."

As well as finding mutations in more than half of the cases examined in the VHL gene previously known to be important in ccRCC, the researchers found evidence for additional mutations in other genes. In particular, they showed that two genes implicated in modulating structural control of gene expression on a genome-wide level had acquired inactivating mutations in ccRCC. These genes, JARID1C and SETD2, encode proteins that move modifying signatures on and off proteins known as histones, which are critical in packaging the DNA thus controlling gene activity. These mutations further elaborate on a theme in ccRCC this team of researchers ha
'/>"/>

Contact: Don Powell
press.officer@sanger.ac.uk
44-122-349-6928
Wellcome Trust Sanger Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Unraveling the Link Between Genes and Environment
2. Physics, Math Provide Clues to Unraveling Cancer
3. March of Dimes Awards $250,000 Prize to Scientists Unraveling the Causes of Muscular Dystrophy
4. Unraveling the Mad Cow Mystery
5. Single-incision belly-button surgery to remove kidney performed first at UT Southwestern
6. Expenses Overshadow Optimism for Kidney Failure Patients
7. Katie Lee Joel to Conduct Cooking Demonstration for Local Patients With Chronic Kidney Disease
8. Lowering Blood Protein Wont Help Kidney Patients
9. DaVita Teammates Bicycling 230 Miles for Kidney Disease Education
10. Stem Cell Therapy Disappoints Against Rare Kidney Ailment
11. Metabolic syndrome heightens risk for development of uric-acid kidney stones
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unraveling kidney cancer
(Date:7/31/2015)... ... 2015 , ... Easter Seals Southern Georgia’s Heels & Wheels Duathlon & Triathlon will be held ... 7:30 AM. The duathlon is a 2 mile run, 13 mile bike ride, and a ... 13 mile bike, and a 3 mile run. Heels & Wheels is sponsored by ...
(Date:7/31/2015)... , ... July 31, 2015 , ... ... same logic applies when purchasing disability insurance, where price is an important factor ... along with a leading insurance carrier, offers the Preferred Producer Multi-Life Discount program, ...
(Date:7/30/2015)... ... ... When responsible for the care of an aging loved one, summer vacations or ... happens if mom falls? Who will remind Dad to take his medications? What if ... taking time away from caregiving responsibilities can lead to bigger problems – caregiver burnout, ...
(Date:7/30/2015)... & Caicos Islands, BWI (PRWEB) , ... July 31, 2015 , ... The Venetian on ... for fall, 2015. Guests who stay at the Venetian will save 40% on their ... The fall months are always quiet in the Turks & Caicos, providing a chance to ...
(Date:7/30/2015)... ... July 30, 2015 , ... World Patent Marketing, ... an app invention that can help people during emergencies. , "The worldwide mobile ... and Creative Director of World Patent Marketing. "Currently, there are about 97,000 mobile ...
Breaking Medicine News(10 mins):Health News:Heels & Wheels for Megan's House Set for Saturday August 22, 2015 in Waycross, Georgia 2Health News:Secura Consultants Gives Advisers Competitive New Edge with Multi-Life Discount Program 2Health News:Aging Life Care Association™ Experts Offer Tips for Caregivers in Need of Vacation Time 2Health News:Aging Life Care Association™ Experts Offer Tips for Caregivers in Need of Vacation Time 3Health News:The Venetian on Grace Bay in Turks & Caicos Islands Offers 40% Savings This Fall. 2Health News:Emergency Alert Can Be A Rude Awakening Without World Patent Marketings New App Invention, I AM FINE 2Health News:Emergency Alert Can Be A Rude Awakening Without World Patent Marketings New App Invention, I AM FINE 3Health News:Emergency Alert Can Be A Rude Awakening Without World Patent Marketings New App Invention, I AM FINE 4Health News:Emergency Alert Can Be A Rude Awakening Without World Patent Marketings New App Invention, I AM FINE 5
... A novel idea to provide health services at supermarkets has ... class of patients who simply hate waiting. These clinics// can ... sprains. ,Take Care Health Systems is planning to ... Peter Eupierre, president of the Illinois State Medical Society is ...
... every month for several problems ranging from arthritis to ... enrolled// in Medicare Part D, the new federal prescription-drug ... plan paid for most of their drugs, minus $20 ... coverage stopped. Donna was told by a pharmacist that ...
... Chris and Caroline Snaith, a couple travelling on a My ... their 10-month-old baby son in Tenerife after the captain// of ... had a spot on his head. The captain thought it ... his grandparents since his mom had an interview to attend. ...
... you have a brain-crushing headache, you are probably better off ... regulatory doses of aspirin, according// to a new study funded ... the active ingredient in aspirin, is naturally available in certain ... are vital ingredients in a curry. ,Researchers at ...
... chewing gum that helps in fighting tooth decay has been developed ... as early as next year. The company claims its// product ... 50 times. The product was developed in collaboration with another ... tooth decay by preventing the Streptococcus mutans (bacteria involved in tooth ...
... junk foods and soft drinks in hospitals, schools and ... diabetes and obesity. Australia// has the world's fastest-growing ... type-2 diabetes. ,In an article published in ... of the International Diabetes Institute in Melbourne, and Philip ...
Cached Medicine News:Health News:Many American senior citizens fall into the “Doughnut Hole” 2Health News:Many American senior citizens fall into the “Doughnut Hole” 3Health News:Many American senior citizens fall into the “Doughnut Hole” 4
(Date:7/30/2015)... July 30, 2015  EP Global Communications, Inc. (Public ... recently contacted the Company about discussing EPGL,s electronic ... as Monday, August 3, 2015.  Novartis CEO ... that the coming electronic contact lens market could ... the next several years.  Novartis partnered with Google ...
(Date:7/30/2015)... 30, 2015  Amgen (NASDAQ: AMGN ) ... of 2015. Key results include: , Total ... of 2014 to $5,370 million, with 6 percent ... (etanercept), Prolia ® (denosumab), Sensipar ® ... ® (denosumab). Unfavorable changes in foreign exchange ...
(Date:7/30/2015)... , July 30, 2015  Cleveland Clinic President ... keynote address last month that industry is compelled to ... to gain the efficiencies—and develop the transformational innovations -- ... Barsoum,s comments were preceded by Doug Kohrs , ... OMTEC moderator, who stressed that industry must add "episode ...
Breaking Medicine Technology:Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 2Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 3Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 4Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 5Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 6Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 7Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 8Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 9Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 10Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 11Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 12Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 13Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 14Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 15Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 16Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 17Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 18Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 19Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 20Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 21Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 22Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 23Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2
... N.J., Dec. 8, 2011  At the Radiological Society ... announced its plans to enter the radiology display ... in display technology to bring a comprehensive line ... "Sony has set the standard for ...
... Dec. 8, 2011 Ecology Coatings, Inc. ... development of nanotechnology-enabled, ultraviolet-curable advanced coatings, today announced ... the rigorous requirements of the healthcare industry.  The ... patient wristband and is benzophenone free—a request that ...
Cached Medicine Technology:Ecology Coatings Develops UV-Curable Coatings for Medical Wristbands 2Ecology Coatings Develops UV-Curable Coatings for Medical Wristbands 3
... easy and economical generation of a hypoxic ... Chamber utilizes a surface-type seal where all ... by a stainless steel ring clamp for ... and semi-spherical top and bottom provide minimum ...
... A wide range of miniTHERM incubators is ... appropriate application solution for their specific requirements. ... liters, are compact and extremely space saving. ... microwave oven. It is possible to stack ...
... A wide range of miniTHERM incubators ... the appropriate application solution for their specific ... 18 liters, are compact and extremely space ... typical microwave oven. It is possible to ...
... corrosion resistance of stainless steel with ... SANYO offers an electro-polished copper-alloy-stainless interior ... The sterile environment promotes the integrity ... the safety of laboratory staff. This ...
Medicine Products: