Navigation Links
Unpublished trial data 'violates an ethical obligation' to study participants, say researchers
Date:10/29/2013

Almost one in three (29%) large clinical trials remain unpublished five years after completion. And of these, 78% have no results publicly available, finds a study published on bmj.com today.

This means that an estimated 250,000 people have been exposed to the risks of trial participation without the societal benefits that accompany the dissemination of their results, say the authors.

They argue that this "violates an ethical obligation that investigators have towards study participants" and call for additional safeguards "to ensure timely public dissemination of trial data."

Randomized clinical trials are a critical means of advancing medical knowledge. They depend on the willingness of people to expose themselves to risks, but the ethical justification for these risks is that society will eventually benefit from the knowledge gained from the trial.

But when trial data remain unpublished, the societal benefit that may have motivated someone to enrol in a study remains unrealized.

US law requires that many trials involving human participants be registered - and their results posted - on the largest clinical trial website ClinicalTrials.gov. But evidence suggests that this legislation has been largely ignored.

So a team of US-based researchers set out to estimate the frequency of non-publication of trial results and, among unpublished studies, the frequency with which results are unavailable in the ClinicalTrials.gov database.

They searched scientific literature databases and identified 585 trials with at least 500 participants that were registered with ClinicalTrials.gov and completed prior to January 2009. The average time between study completion and the final literature search (November 2012) was 60 m
'/>"/>

Contact: Stephanie Burns
sburns@bmj.com
44-020-738-36920
BMJ-British Medical Journal
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brain Tumor Vaccine Shows Promise in Early Trial
2. URMC clinical trial tests new regimen for hypertension
3. Analysis Finds Clinical Trials Often Small, of Poor Quality
4. US spends far more for health care than 12 industrialized nations, but quality varies
5. New Weight-Loss Drug Shows Promise in Trial
6. Palpitations are predictive of future atrial fibrillation
7. Trial Set to See if Drug Can Prevent Alzheimers
8. Experts call for clinical trials to test non-skeletal benefits of vitamin D
9. Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
10. Canada should significantly increase its funding of randomized clinical trials
11. Alzheimers vaccine trial a success
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... 2014 Fuel additives are chemicals, which ... jet fuel, kerosene, and so on, in order to ... reducing the corrosion effects caused by fuels and improving ... any fuel, provide economies of scale in the long ... overall cost of the fuel products. , The various ...
(Date:7/13/2014)... July 13, 2014 MarketsandMarkets recently ... [3D Modeling; 3D Scanning; 3D rendering; Layout and ... Analysis (2013 - 2018)”, which analyzes and studies ... North America, Western Europe, Eastern Europe, Middle East ... also draws the competitive landscape of the 3D ...
(Date:7/13/2014)... HealthDay Reporter FRIDAY, July 11, 2014 (HealthDay ... with diabetes is being developed to measure sugar levels in ... Scientists at Brown University in Providence, R.I., created the sensor ... metal and a special enzyme that changes color when exposed ... prick their fingers to draw blood to check their blood ...
(Date:7/13/2014)... WA (PRWEB) July 13, 2014 Athletes ... longer recovery period from concussions, according to research presented ... ( AOSSM ) Annual Meeting. The research marks the ... concussion based on the known physical events that occur ... patients with a long allele in the (GT)n genotype ...
(Date:7/13/2014)... July 13, 2014 Recently, 2014QuinceaneraDresses.com, ... has unveiled its new range of gorgeous ... market, the demand for elegant Quinceanera outfits is ... beautiful items. All the company’s newly released dresses ... They are all elegant and vivid. , ...
Breaking Medicine News(10 mins):Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 2Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 4Health News:Saliva Test Might Someday Replace Needle Prick for Diabetics 2Health News:Saliva Test Might Someday Replace Needle Prick for Diabetics 3Health News:Genetic Factors May Be Responsible for Slowing Concussion Recovery in Athletes 2Health News:2014QuinceaneraDresses.com Releases Its New Quinceanera Dresses 2
... allays some concerns about how patients interpret results, researchers ... genetic testing for lung cancer appears to offer some ... the use of an online test among 44 smokers. ... model for genetic testing. You see a professional genetics ...
... , BOISE, Idaho, June 30 WinCo Foods , LLC ... ground beef items sold at some of its stores between ... by the expanded recall of beef products by the JBS ... recall of beef products that could potentially be contaminated with ...
... Labatt Family School of Nursing at The University of Western ... issues surrounding the chronic shortage of registered nurses in Canada ... named the first Arthur Labatt Family Nursing Research Chair in ... Canadian Nurses Association found the country will be short 78,000 ...
... humor and a family,s story to encourage individuals to call ... community , , WASHINGTON, June 30 Baldo and ... Alliance for Hispanic Health (the Alliance) to get the word ... of comic strips that begin today, June 30th, and run ...
... , OMAHA, Neb. and PHOENIX, Ariz., June 30 ... Joseph,s Hospital and Medical Center in Phoenix today announced an ... school presence in Phoenix. , , The Phoenix ... School of Medicine at St. Joseph,s Hospital and Medical Center, ...
... (TB) is a difficult infection to treat and requires ... To combat the TB pandemic, a shorter and simpler ... TB occurs in resource-limited settings with poor public health ... measurements might help identify which TB patients could benefit ...
Cached Medicine News:Health News:Online Genetic Testing Appears to Have Benefits 2Health News:WinCo Foods Voluntarily Recalls Beef and Ground Beef Sold at Some Stores Between May 9 and May 15, 2009 Due to Possible Contamination 2Health News:Finding solutions to the chronic nursing shortage 2Health News:Comic Strip Delivers Message on Diabetes Health 2Health News:Comic Strip Delivers Message on Diabetes Health 3Health News:Creighton University, St. Joseph's Hospital and Medical Center Announce New School of Medicine Campus in Phoenix 2Health News:Measurements fail to identify TB patients who could benefit from shorter treatment course 2
(Date:7/10/2014)... , July 10, 2014  The U.S. Department of ... grant to University Hospitals (UH) Case Medical Center Seidman ... national model aimed at improving care for patients with ... the project will test a unique model developed at ... late-stage disease, significant comorbidities, or demonstrated need for high ...
(Date:7/10/2014)... Yesterday, former Congressman Patrick Kennedy ... facility. Rep. Kennedy and Dick Moberg ... research in neurological disease and treatment. ... Garen Staglin , created One Mind, a ... that will radically accelerate the development and implementation ...
(Date:7/10/2014)... July 10, 2014  Decision Resources Group finds ... disease (ID) specialists are willing to prescribe Durata,s ... for use as OPAT, approximately two-thirds of the ... to their hospital inpatients. However, our findings indicate ... are initiated on OPAT following hospital discharge, and ...
Breaking Medicine Technology:University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3
... NEW YORK, Feb. 24, 2011 Reportlinker.com announces that ... catalogue: Global Orthopedic Orthotics Industry ... report analyzes the worldwide markets for Orthopedic Orthotics in ... (Knee Braces, Ankle Braces, & Others) and Orthopedic Support ...
... 2011 Reportlinker.com announces that a new market ... Global Cardiac Defibrillators Industry ... analyzes the worldwide markets for Cardiac Defibrillators in ... US markets is analyzed by the following segments ...
Cached Medicine Technology:Reportlinker Adds Global Orthopedic Orthotics Industry 2Reportlinker Adds Global Cardiac Defibrillators Industry 2
The Lineage acetabular system with UHMWPE liners provide lipped options for increased femoral head coverage promoting a stable joint....
Hemisphere modular Cup....
Link All-Poly acetabular cups for cement....
Metal on metal hip acetabular cups available for both cemented and cementless applications, the Biomet Merck metal on metal articulation hip system (M2aTM) combines proven materials with the latest i...
Medicine Products: