Navigation Links
Unlocking the secrets of DNA repair
Date:10/31/2012

Scientists from the University of Sheffield have unlocked one of the secrets to DNA repair helping doctors identify DNA base damage and a patient's susceptibility to certain types of cancer.

Groundbreaking research led by Dr David Williams from the University of Sheffield's Department of Chemistry and an international collaboration of expert researchers has discovered how some proteins recognise damaged bases within DNA which, if untreated, could lead to cancer.

Dr Williams said: "Proteins carry out all the day-to-day processes needed for survival. If the DNA bases become damaged the associated protein may not function or in some cases, too much of a certain protein can be produced which might lead to cancer.

"Everyday humans are exposed to chemicals known as alkylating agents which may be derived from environmental sources or from dietary sources such as a high intake of red or processed meat or exposure to tobacco smoke. Alkylating agents can chemically modify the bases in DNA which can, in turn, lead to non-functional proteins being produced or indeed cancer.

"Fortunately humans have a large number of different DNA repair proteins whose task it is to find and repair damaged bases in DNA. However DNA base damage, although highly problematic, is rare and often only one or two bases per million or even fewer. The task of locating a damaged base is similar to finding a needle in a haystack."

DNA contains all the information needed for life within the sequence of its four bases; adenine, cytosine, guanine and thymine. Specific sequences of bases in DNA known as genes instruct what proteins are made and furthermore genes may be switched on or off to control how much of each protein is made.

The pioneering research, published in the journal: Proceeding of the National Academy of Sciences of the United States of America (PNAS), was conducted by scientists from the University of Sheffield, Univer
'/>"/>

Contact: Amy Pullan
a.l.pullan@sheffield.ac.uk
01-142-229-859
University of Sheffield
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Dotcomsecrets is Offering New Opportunities to People Who Want to Become Expert in Localized Internet Marketing
2. DotComSecrets Invites Professionals to Learn Great Tips On How to Make a Handsome Income By Working As Local Internet Marketing Consultants
3. 13 Free Weight Loss Secrets Program Kicks-Off
4. DotComSecrets Offers Free Webinar to Make Individuals Skilled in Earning Thousands of Dollars by Becoming DCS’s Local Consultant
5. DotComSecrets’ Russell Brunson Is Revealing Online Money Making Secrets in Free Webinars for Students
6. DotComSecrets Is Seeking Local DCS Consultants Through Free Webinars in Coming Days
7. Secrets of lung cancer drug resistance revealed at UCSF
8. Could the Naked Mole Rat Hold Secrets to Longevity?
9. UMass Amherst researchers unravel secrets of parasites replication
10. Unmasking the deadly secrets of pancreatic cancer
11. Researchers Repair Damage Caused by Heart Attacks in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... research co-funded by the Engineering and Physical Sciences ... of the UK,s vital industrial control systems which ... electricity grid, and the rail network. , ... from hackers or malware infiltrating the systems behind ... Institute in Trustworthy Industrial Control Systems (RITICS), based ...
(Date:10/1/2014)... 01, 2014 Marriagelifeinsurance.com has released ... insurance for retired couples. , Senior citizens can ... security for their loved ones. A joint policy is ... persons pass away. , Life insurance can be ... insurance can even be purchased online, as the application ...
(Date:10/1/2014)... Phoseon Technology, the pioneer in developing ... business worldwide. This rapid growth includes increased hiring for ... efforts. The company has experienced average annual growth rates ... this growth to continue in the future as new ... , “We are very pleased that UV ...
(Date:10/1/2014)... 01, 2014 Beverly Hills licensed Clinical ... is celebrating 20 years of private practice in her ... people to achieve greater joy and fulfillment in their ... warning signs and suggestions for anyone who suspects they ... “Believe it or not, it’s not always easy ...
(Date:10/1/2014)... Anti Aging Clinic (AntiAgingClinic.ca), the Greater ... of choice, is announcing a discounted cost on Botox ... , “We’re doing this because we want to give ... skin clinic in Toronto,” says Dr. Brian Sieber, founder ... Anti Aging Clinic, including laser facials, genesis laser facials, ...
Breaking Medicine News(10 mins):Health News:£2.5 million to recognize and reduce cyber-attack threats to critical infrastructure 2Health News:Elderly Life Insurance - Find Life Insurance for Retired Couples! 2Health News:Phoseon Technology Continues to Drive Growth Worldwide 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 3Health News:Anti Aging Clinic, the GTA’s Premier Provider of Anti Aging Treatments, Announces Deal on Units of Botox 2
... June 13 (Pink Sheets: ICTY) As of,June 11, ... that is,going to completely revamp the company and move ... very tight and secure team of corporate,individuals are in ... must be addressed prior to the release of any ...
... HILL, N.C., June 13 Market competition ... interest of the most highly,qualified clinical investigators. ... clinical investigators to their studies win an ... Best Practices, LLC,s white paper "Recruiting and ...
... could detect disease sooner, when it,s more treatable , , FRIDAY, ... development of pancreatic cancer have been identified by U.S. researchers, ... to develop a blood test to detect this type of ... , "Our team identified, for the first time, protein ...
... Paris, France, Friday 13 June 2008: Rheumatoid ... (PsA) patients should undergo compulsory cardiovascular (CV) risk ... adapted to the increased CV risk in inflammatory ... ,Cardiovascular Risk Management in RA, recommended today at ...
... End of Life Urges Congress to Preserve ... Compassionate End-of-Life Care, WASHINGTON, June ... Payment Advisory Commission (MedPAC),reported that the rapid growth of the Medicare ... and more spending per,beneficiary. According to the report, "Evaluating Medicare,s Hospice,Benefit," ...
... 13 June 2008: A new DNA microarray chip can ... arthritis (RA), as presented today at EULAR 2008, the ... Paris, France. The chip (called the ,ARTchip,) has yielded ... in anticipating likely disease progression and prognosis and thereby ...
Cached Medicine News:Health News:EyeCity.com, Inc. Changes Ownership and Moves Into a New Direction 2Health News:Pancreatic Cancer Biomarkers Found 2Health News:CV risk management should be mandatory in RA and other types of inflammatory rheumatic disease 2Health News:CV risk management should be mandatory in RA and other types of inflammatory rheumatic disease 3Health News:More Data Needed Before Changing Medicare Hospice Funding, Report Finds 2Health News:More Data Needed Before Changing Medicare Hospice Funding, Report Finds 3Health News:Novel DNA microarray chip predicts functional impairment and remission in rheumatoid arthritis 2
(Date:9/30/2014)... Sept. 30, 2014  Tasly Pharmaceuticals, Inc., the ... medicine, announced today the launch of Deepure. ... to address men and women concerned with supporting ... into old age while helping keep their health ... whole-food and herb-based formulas, namely, ProHeart PLUS, ImmunoPower ...
(Date:9/30/2014)... , Sept. 30, 2014 Arbor Pharmaceuticals, ... Summary Global Markets Direct,s, ,Arbor Pharmaceuticals, LLC. ... overview of the Arbor Pharmaceuticals, LLC.,s pharmaceutical research ... information on the current therapeutic developmental pipeline of ... various stages, therapeutics assessment by drug target, mechanism ...
(Date:9/30/2014)... Sept. 30, 2014  Decision Resources Group finds that the ... , China , India ... a strong rate through 2023. Dental implant procedure volumes will grow ... awareness rises. Other key findings from Decision Resources Group,s ... market: , Dental implant penetration: Penetration of dental ...
Breaking Medicine Technology:Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 2Arbor Pharmaceuticals, LLC. - Product Pipeline Review - 2014 3Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 2Asia Pacific Dental Implant Market Will Grow at a Strong Rate Through 2023 3
... Study Comparing Leading Hepatitis C Therapies Provides ... Insights to Help Guide Clinical Practice, MILAN, Italy, ... first large, randomized, clinical study comparing the,leading therapies for ... Meeting of the European Association for the Study of ...
... of treatment with R7128 1500mg BID with Pegasys(R) plus Copegus(R) -, - Safety and ... ... presentation available on Pharmasset website -, - Conference call scheduled for Friday, April 25, 2008 at ... and 7:00 PM CEST (Milan) -, ...
Cached Medicine Technology:Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL) 2Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL) 3Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL) 4Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL) 5Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL) 6Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL) 7Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL) 8Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL) 9Final Results of Ideal Study Presented at Annual Meeting of the European Association for the Study of the Liver (EASL) 10Pharmasset Presents Results of 4-Week Combination Study of R7128 for the Treatment of Chronic Hepatitis C 2Pharmasset Presents Results of 4-Week Combination Study of R7128 for the Treatment of Chronic Hepatitis C 3Pharmasset Presents Results of 4-Week Combination Study of R7128 for the Treatment of Chronic Hepatitis C 4Pharmasset Presents Results of 4-Week Combination Study of R7128 for the Treatment of Chronic Hepatitis C 5Pharmasset Presents Results of 4-Week Combination Study of R7128 for the Treatment of Chronic Hepatitis C 6
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: