Navigation Links
Unlocking the key to human fertility
Date:8/3/2009

is a definite pattern to the way DNA is packaged in sperm cells and we can see that this pattern is the same in unrelated fertile men. It is different in the sperm of infertile men. This implies that there is a significance to the packaging of DNA that has a direct relevance to male fertility," says Dr Iles.

Detailed analyses of the DNA in the 'open', less tightly packaged conformation, showed this DNA carries much of the information critical for activating genes essential for directing the development of the embryo. Further investigations showed the same conformation to exist in the sperm of several unrelated human donors and remarkably, highly similar packaging patterns to exist in the sperm of mice.

DNA regions in the 'open' conformation may therefore be more vulnerable to damaging toxins, such as those in cigarette smoke and certain anti-cancer drugs, than those that are tightly packaged. As Dr Brinkworth says, "this might mean that anything capable of causing genetic damage to sperm could have particular significance for the development of the embryo".

The findings also help explain why inter-species breeding is so rarely successful. Where the locks and keys of two species do not match, however similar their DNA is, no viable offspring can be born. Occasionally, for example, with horses and donkeys, offspring are produced - but because the sperm and egg signatures are incompatible, their development as embryos is abnormal and any offspring are almost always infertile.

The research team believes that the same mechanism must also have played a role during human evolution. In the ancient history of mankind, Neanderthals co-existed with modern humans over many thousands of years. Sexual encounters between these two closely related species cannot be ruled out, yet there is no evidence in our DNA of a legacy from such couplings. It is possible that if offspring were produced, they either did not survive long or if they did, t
'/>"/>

Contact: Dr. David Iles
d.e.iles@leeds.ac.uk
44-113-343-2890
University of Leeds
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Zenger Folkman Releases Latest Book: The Inspiring Leader: Unlocking the Secrets of How Extraordinary Leaders Motivate
2. United Spinal Association Reports Positive Results of Stem Cell Transplantation to Treat Multiple Sclerosis: Study May be Key to Unlocking a Cure
3. Unlocking the mysteries of memory
4. Unlocking the promise of clinical and translational science
5. Unlocking mysteries of brain cancer, stroke
6. Scientists ID First Human With Gorilla Strain of HIV
7. Webinar Offers Tips for Meeting Compliance Communications and Provides HRCI Credit for Human Resource Professionals
8. Human Pheromones: Whats Purported, Whats Supported - A White Paper Published by The Sense of Smell Institute
9. MEK4, genistein and invasion of human prostate cancer cells
10. Humanitas Designated as Approved Provider by California Board of Registered Nursing for Continuing Education Course Credit and Units
11. Itanium Solutions Alliance Selects Swedens Kiwok as the 2009 Innovation Awards Winner for Humanitarian Impact
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... August 28, 2015 , ... With the goal of furthering ... the second year to the Adams County Fairgrounds in Mendon, IL on May 30th, ... money to support music education in the underfunded school districts of Mendon and its ...
(Date:8/28/2015)... ... , ... As reported by Medical Daily on August 22 , Cellfina, ... last for two years, the longest of any cellulite reduction system currently on the ... long-lasting, effective solution for their cellulite, according to Dr. Robert Weiss, director of the ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... who might personally be struggling with chemical dependency, may be able to find ... Rehabilitation, a results-driven holistic treatment center for addiction located in Western Michigan. Focusing ...
(Date:8/28/2015)... ... 28, 2015 , ... Altima Technologies, Inc., the maker of ... center assets and audio-video devices, recently released Visio Stencils for the following product ... Gen9, EMC VNX Series , Super Micro Computer SuperStorage, Hitachi Data Systems Virtual ...
(Date:8/28/2015)... , ... August 28, 2015 , ... ... the Veterans Award, honoring military veterans leading in business. Mr. Troy Mizell, ... , The inaugural Nashville Business Journal's 2015 Veterans Awards will recognize Nashville ...
Breaking Medicine News(10 mins):Health News:Best Drug Rehabilitation Interviews Country-Rock Duo Highway Run at the 2015 "Music With A Mission" Benefit Concert 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 3Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 2Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 3Health News:Altima Updates NetZoomâ„¢ Visio® Stencil Library for Cisco, HP, and EMC Devices 2Health News:Altima Updates NetZoomâ„¢ Visio® Stencil Library for Cisco, HP, and EMC Devices 3Health News:MyGenetx Board Member Receives Veterans Award 2
... EXTON, Pa., Nov. 2 Kensey Nash Corporation,(Nasdaq: ... exclusively licensed U.S. patent,6,175,669, Optical Coherence Domain Reflectometry ... expand the intellectual,property portfolio related to its chronic ... with enhanced optical sensing capabilities,allowing it to sense ...
... 24%, Digital Revenue Up 30% ... a.m. Eastern Time, NASHUA, N.H., Nov. 2 iCAD, ... the early detection of cancer, today announced financial,results for the ... nine,months year to date for 2007. Third Quarter 2007 ...
... to get screened for each point scored, CENTENNIAL, ... to great lengths to show support for their favorite ... freezing temperatures, traveling,great distances for the big game. Now ... health by raising awareness of a deadly disease --,prostate ...
... while complying ... US applicable standards, FREDERICA, Del., Nov. 1 ... the pharmaceutical industry,as well as spacesuits for NASA, announced ... use in their DoverPac (R) Containment Solution,products. ArmorFlex (R) ...
... 1 HHS Secretary Mike,Leavitt signed a Memorandum ... Clement today to improve the health status of ... best practices, and innovative approaches to learning,opportunities., ... HHS, national,headquarters., The MOU, which continues the ...
... Inc. (Nasdaq:,IFLG), a leading technology provider of mobile ... release its financial results,for the Third Quarter ended ... the press release, President and Chief Executive Officer,David ... host a conference,call with the financial community at ...
Cached Medicine News:Health News:Kensey Nash Announces Exclusive License of Optical Guidance Patent to Enhance Chronic Total Occlusion Platform 2Health News:Kensey Nash Announces Exclusive License of Optical Guidance Patent to Enhance Chronic Total Occlusion Platform 3Health News:iCAD Reports Third Quarter Results 2Health News:iCAD Reports Third Quarter Results 3Health News:iCAD Reports Third Quarter Results 4Health News:iCAD Reports Third Quarter Results 5Health News:iCAD Reports Third Quarter Results 6Health News:iCAD Reports Third Quarter Results 7Health News:iCAD Reports Third Quarter Results 8Health News:Professional Football Takes the Field to Tackle Prostate Cancer 2Health News:Professional Football Takes the Field to Tackle Prostate Cancer 3Health News:ILC Dover Launches Revolutionary ArmorFlex (R) Pharmaceutical Product Contact Film 2Health News:HHS Secretary Leavitt Signs Agreement With Canada to Improve Indigenous Health Care Delivery and Access 2Health News:InfoLogix to Report Third Quarter and Nine Month Financial Results on November 8, 2007 2
(Date:8/28/2015)... , Aug. 28, 2015 ... the addition of the "Investigation Report on China,s ... Developed by Roche under the trade name of ... the world. In Feb.26, 2010, it was approved by ... available in China all come ...
(Date:8/28/2015)... DRAPER, Utah , Aug. 28, 2015  Today, ... and Prevention,s (CDC) Contact Lens Health Week, 1-800 Contacts ... CDC has found that contact lens wearers who do ... the greatest risk for eye infections. ... cleaning their lenses, but a clean lens case is ...
(Date:8/28/2015)... 2015 Research and ... the "Investigation Report on China,s Insulin Aspart ... Developed by Novo Nordisk, insulin aspart (under ... drug for the treatment of diabetes. Compared with ... insulin analog, starts working fast and reports higher ...
Breaking Medicine Technology:Investigation Report on China's Bevacizumab Market 2015-2019 21-800 Contacts Shares Tips on How to Clean Lens Cases 2China Insulin Aspart Market Report 2010-2019 - Developed by Novo Nordisk 2
... study shows that loss of Arf gene in ... the growth-enhancing environment of the bone,marrow, helping cells ... MEMPHIS, Tenn., Aug. 29 Results of a ... provide strong,evidence for why the drug imatinib (Gleevec(TM)), ...
... Aug. 29 Accera, Inc. announced today,that recent data ... Ketasyn(TM),(AC- 1202) in age-associated memory impairment (AAMI) showed that ... in older adults. AAMI is the decline in ... National Institute of Mental Health criteria for AAMI include,complaints ...
Cached Medicine Technology:St. Jude Discovers Factors That Accelerate Resistance to Gleevec(TM) Targeted Therapy in Lymphoblastic Leukemia 2Experimental Drug Ketasyn(TM) Improves Memory in Age-Associated Memory Impairment Study 2Experimental Drug Ketasyn(TM) Improves Memory in Age-Associated Memory Impairment Study 3
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Deflected large type, opening width 8.0 mm and length 5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Fenestrated large type 1/1 (mm), opening width 8.0 mm and length 10 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Fenestrated large type 1/1 (mm), opening width 8.0 mm and length 7.5 mm....
Extremely wide blade opening. Excellent bio and MRI compatibility. Lot number on each clip. Long reliable history. Large type 1/1 (mm), opening width 10.0 mm and length 10 mm....
Medicine Products: