Navigation Links
Unlocking the genetic mysteries behind stillbirth
Date:12/6/2012

Galveston, Texas Stillbirth is a tragedy that occurs in one of every 160 births in the United States. Compounding the sadness for many families, the standard medical test used to examine fetal chromosomes often can't pin down what caused their baby to die in utero. In most cases, the cause of the stillbirth is not immediately known. The traditional way to determine what happened is to examine the baby's chromosomes using a technique called karyotyping. This method leaves much to be desired because, in many cases, it fails to provide any result at all. Today, some 25 to 60 percent of stillbirths are still unexplained.

A new test for analyzing the chromosomes of stillborn babies, known as microarray analysis, has now proven 40 percent more effective in pinpointing potential genetic causes of death than the old karyotype testing procedure. Researchers at the University of Texas Medical Branch at Galveston, along with a team of other national leaders in maternal-fetal medicine, have published their findings in the Dec. 6 New England Journal of Medicine.

"Families have a much greater sense of closure if they understand what likely caused their baby to die," said Dr. George Saade, lead investigator of the UTMB arm of the study. "And for doctors to be able to see more genetic information about each stillborn baby can only be a good thing in terms of continuing the fight to reduce stillbirths worldwide."

Stillbirth, as defined separately from miscarriage, is when a baby dies in the womb prior to delivery at or after 20 weeks of gestation.

The study, part of the National Institutes of Health Stillbirth Collaborative Research Network's ongoing program, showed that microarray analysis genetic testing offers families strikingly more information than karyotyping about what potentially caused their baby to die before it was born. UTMB's Saade is the lead investigator for the study at UTMB, and chairman of the genetics committee for the Stillbirth Network.

The researchers compared the results of karyotypes from more than 500 stillbirths to results from microarray analysis, a method that detects small segments of missing parts of chromosomes (deletions) or additional sections of genetic material (duplications) that cannot be seen by karyotyping.

They analyzed samples from all stillbirths in a population-based study in five U.S. areas, covered by 59 hospitals over a period of two and a half years. Shortly after each stillbirth, parents gave research staff permission to collect blood from the umbilical cord and tissue from the fetus and the placenta.

The UTMB research team's goal was to reach the parents of 90 percent of all stillborn babies to residents of Galveston and Brazoria counties during the time period of the study. To achieve this, they formed partnerships with 11 hospitals in the region and developed a methodology whereby stillbirths were reported immediately to UTMB if the stillborn child's parents granted permission. Upon notification, UTMB sent staff members to the hospital to meet with the bereaved families.

If the families agreed to take part in the study, UTMB staff members then worked with the participating hospitals to transport the babies to Galveston for genetic testing and/or autopsy before arranging with funeral homes for the babies' final transport. About 100 stillbirths occurred in the Galveston/Brazoria county region during the two and a half years the study took place.

"It's really something, that families in such a tough situation, with all the shock and sadness they must be feeling upon the loss of their baby, would be willing to work with us to conduct this important stillbirth research," said Saade.

The hospitals included in the UTMB arm of the study were Angleton Danbury Medical Center, Brazosport Memorial Hospital, Clear Lake Regional Medical Center, Memorial Hermann Hospital, Mainland Medical Center, Methodist Hospital, Memorial Hermann Southeast Hospital, Christus St. John Hospital, St. Joseph Medical Center, St. Luke's Episcopal Hospital, the Woman's Hospital of Texas and UTMB.

"We are so glad that the data from our region was included in this important national study," said Saade. "We are proud here at UTMB that our national reputation as a leader in maternal-fetal clinical research has enabled us to be part of this Network and study, and that we were able to work with such an outstanding group of participating hospitals."


'/>"/>

Contact: Molly Dannenmaier
mjdannen@utmb.edu
409-771-5105
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. Unlocking the secrets of DNA repair
2. New evidence for epigenetic effects of diet on healthy aging
3. Genetic data shows that skin cancer risk includes more than UV exposure
4. Genetics Society of Americas Genetics journal highlights for December 2012
5. McKinney Orthodontics Educates on New Evidence that Crooked Teeth are Genetic
6. Genetic factor holds key to blood vessel health
7. A new factor of genetic susceptibility to Alzheimers disease
8. Optogenetics illuminates pathways of motivation through brain, Stanford study shows
9. Genetics point to serious pregnancy complication
10. Worlds largest respiratory genetics study launches on World COPD Day
11. Genetic link between pancreatitis and alcohol consumption, says Pitt team
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg ... Legal Elite. The attorneys chosen by their peers for this recognition are considered among ... Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite Hall ...
(Date:6/24/2016)... ... ... Comfort Keepers® of San Diego, CA is excited to announce they are ... drive cancer patients to and from their cancer treatments. Comfort Keepers provides quality ... and ongoing independence. Getting to and from medical treatments is one of the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
(Date:6/24/2016)... 2016 Dehaier Medical Systems Ltd. (NASDAQ: ... markets and sells medical devices and wearable sleep respiratory ... strategic cooperation agreement with Hongyuan Supply Chain Management Co., ... June 20, 2016, to develop Dehaier,s new Internet medical ... Dehaier will leverage Hongyuan Supply Chain,s sales platform to ...
Breaking Medicine Technology: