Navigation Links
Unlocking the genetic and molecular mystery of soft-tissue sarcoma
Date:11/30/2011

BostonNOVEMBER 30, 2011Scientists at Joslin Diabetes Center in Boston have uncovered important molecular and genetic keys to the development of soft-tissue sarcomas in skeletal muscle, giving researchers and clinicians additional targets to stop the growth of these often deadly tumors.

Published in the Proceedings of the National Academy of Sciences, the study identified two major molecular signaling pathways (the Ras and mTOR pathways) that are common in tumor growth and development. These molecular pathways regulate cell growth and division, two cellular properties whose over-activation are hallmarks of cancer biology.

"In humans, some sarcomas respond to chemotherapy," says lead author Amy J. Wagers, PhD, an associate professor of stem cell and regenerative biology at Harvard Medical School and Joslin Diabetes Center, "but many don't. With these findings, we have vetted a list of new candidate targets whose inhibition may lead to regression of these tumors. "

Many soft-tissue sarcomas, which develop in certain tissues such as bone and muscle, carry specific genetic mutations or unique gene signatures, which can allow scientists to develop more precise, targeted therapies. Wagers and her colleagues engineered a tumor system in mice by introducing into mouse skeletal muscle a cancer-carrying gene, or oncogene, known to cause tumors in humans. They used this engineered system to identify a small set of genes that are active in sarcoma tumors.

There are many different types of soft-tissue sarcomas, which develop in tissues that connect, support or surround other structures and organs, including muscle, tendons, nerves, fat and blood vessels. If diagnosed early, treatment, primarily through surgical removal of the tumor, radiation therapy or chemotherapy, can be effective. If the tumor has spread, however, the tumor can be controlled only for a period of time, but treatment does not often cure the disease.

B
'/>"/>

Contact: Jeffrey Bright
jeffrey.bright@joslin.harvard.edu
617-309-1957
Joslin Diabetes Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Unlocking jams in fluid materials
2. UNC researchers inch closer to unlocking potential of synthetic blood
3. Unlocking the secret of beauty: Scientists discover the complexities of attractive female bodies
4. Unlocking the Immune System's Response to Infection and Injury
5. CU-Boulder led study of smoking twins points to growing influence of genetic factors
6. Increasing dosage of clopidogrel for patients with genetic variation improves response to medication
7. Combination epigenetic therapy clinical trial results
8. Epigenetic therapy shows promise in hard-to-treat lung cancer
9. Breakthrough in understanding the genetics of high blood pressure
10. Possible Genetic Link to Autism Identified
11. Ohio State researchers design a viral vector to treat a genetic form of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unlocking the genetic and molecular mystery of soft-tissue sarcoma
(Date:9/23/2014)... September 23, 2014 Ale Gicqueau, President ... on Advanced Data Visualization for Clinical Trials at the ... in San Francisco on Friday, September 26, 2014. ... volunteers. Since its inception, PhUSE has expanded from its ... a global platform for the discussion of topics encompassing ...
(Date:9/23/2014)... 23, 2014 WetKeys Washable Keyboards announces ... in their industrial keyboards line. Labeled ... to last longer in heavy-duty industrial computing for the ... where grease and oil can destroy usability or cause ... constant threat to the longevity of computer equipment and ...
(Date:9/23/2014)... September 23, 2014 With the emergence ... sale of all tobacco products, retail chains are transforming ... services to patients, customers, and shoppers. In this capacity, ... of retail pharmacy healthcare to share their knowledge on ... to know to coordinate care with other colleagues inside ...
(Date:9/23/2014)... Névo takes a bold step forward in fitness ... activity tracking and phone notifications for a fashion conscious ... and more. , http://www.nevowatch.com , “Today, ... their busy lives to look and feel better. The ... results, but until now, style played a distance second ...
(Date:9/23/2014)... 23, 2014 Published by Nationwide Lifts, the ... to take charge of their mobility in a new way, ... impactful. Stair lifts are that equipment and can ... in the elevator business, I’ve seen so many ... or a loved one with mobility issues,” said Andy Darnley, ...
Breaking Medicine News(10 mins):Health News:Clinovo Sponsors and Presents at Pharmaceutical Users Software Exchange (PhUSE) SDE in San Francisco 2Health News:WetKeys Announces New Oil Resistant Keyboard for Industrial Computing, Food Processing Plants, Automotive Factories and Machine Shops 2Health News:WetKeys Announces New Oil Resistant Keyboard for Industrial Computing, Food Processing Plants, Automotive Factories and Machine Shops 3Health News:WetKeys Announces New Oil Resistant Keyboard for Industrial Computing, Food Processing Plants, Automotive Factories and Machine Shops 4Health News:WetKeys Announces New Oil Resistant Keyboard for Industrial Computing, Food Processing Plants, Automotive Factories and Machine Shops 5Health News:Retail Pharmacies at the Forefront of Primary Care Innovation 2Health News:Nevo changes the face of fitness wearables with an analogue watch combining activity tracking, phone notifications, and LED goal progress indicators for active lifestyles 2Health News:Nevo changes the face of fitness wearables with an analogue watch combining activity tracking, phone notifications, and LED goal progress indicators for active lifestyles 3Health News:Nationwide Lifts, America’s Leader in Home Elevators, Is Proud to Announce the Release of Its First Book, “Stair Lifts: Move Up, Not Out!” 2
(Date:9/22/2014)... Sept. 22, 2014 Decision Resources Group finds that ... expected to be worth $2 billion (U.S. dollars), increasing at ... next five years (to 2018). This growth comes as ... in 2013 and 4.9 percent expected over the next three ... is small but highly competitive. The pharmaceutical market is dominated ...
(Date:9/22/2014)... -- Persistence Market Research ( http://www.persistencemarketresearch.com/ ) ... Ophthalmic Devices: Asia to Witness ... at USD 29,171.5 million in 2014 and is expected ... to 2020, to reach an estimated value of USD ... Market Study on Ophthalmic Devices:  Asia  to ...
(Date:9/22/2014)... , Sept. 22, 2014  AVT, Inc. (OTC ... retailing systems and custom vending machines, announced today that ... Unit. This new, smaller sized unit is designed for ... practices. According to industry statistics, there are ... Opticwash is the world,s first automated kiosk ...
Breaking Medicine Technology:Despite Its Limited Size, Chile's Pharmaceutical Market Offers Growing Opportunity for Drug Industry 2Despite Its Limited Size, Chile's Pharmaceutical Market Offers Growing Opportunity for Drug Industry 3Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 2Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 3Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 4Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 5Opticwash Pro Enables Optical Retailers to Generate New Revenues and Customer Traffic through a Unique Eyeglass Cleaning System 2
... LAKES, N.J., Dec. 29 BD (Becton, Dickinson and Company) (NYSE: ... would present at the following investor healthcare conferences in January: , , ... 6, 2010, 9:15 a.m. ET, 28th ... 6:30 p.m. ET, , A live webcast of BD,s ...
... PALM CITY, Fla., Dec. 29 Connectyx Technologies Holdings Group, ... a National RV Owners Community as a marketing partner to ... over one million members and more than 3,400 individual club ... The RV Club provides its membership with essential services ranging ...
Cached Medicine Technology:BD to Present at Investor Healthcare Conferences 2Connectyx Announces MedFlash Sales Partnership with National Recreational Vehicle Club 2Connectyx Announces MedFlash Sales Partnership with National Recreational Vehicle Club 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: