Navigation Links
Unlocking the genetic and molecular mystery of soft-tissue sarcoma
Date:11/30/2011

BostonNOVEMBER 30, 2011Scientists at Joslin Diabetes Center in Boston have uncovered important molecular and genetic keys to the development of soft-tissue sarcomas in skeletal muscle, giving researchers and clinicians additional targets to stop the growth of these often deadly tumors.

Published in the Proceedings of the National Academy of Sciences, the study identified two major molecular signaling pathways (the Ras and mTOR pathways) that are common in tumor growth and development. These molecular pathways regulate cell growth and division, two cellular properties whose over-activation are hallmarks of cancer biology.

"In humans, some sarcomas respond to chemotherapy," says lead author Amy J. Wagers, PhD, an associate professor of stem cell and regenerative biology at Harvard Medical School and Joslin Diabetes Center, "but many don't. With these findings, we have vetted a list of new candidate targets whose inhibition may lead to regression of these tumors. "

Many soft-tissue sarcomas, which develop in certain tissues such as bone and muscle, carry specific genetic mutations or unique gene signatures, which can allow scientists to develop more precise, targeted therapies. Wagers and her colleagues engineered a tumor system in mice by introducing into mouse skeletal muscle a cancer-carrying gene, or oncogene, known to cause tumors in humans. They used this engineered system to identify a small set of genes that are active in sarcoma tumors.

There are many different types of soft-tissue sarcomas, which develop in tissues that connect, support or surround other structures and organs, including muscle, tendons, nerves, fat and blood vessels. If diagnosed early, treatment, primarily through surgical removal of the tumor, radiation therapy or chemotherapy, can be effective. If the tumor has spread, however, the tumor can be controlled only for a period of time, but treatment does not often cure the disease.

B
'/>"/>

Contact: Jeffrey Bright
jeffrey.bright@joslin.harvard.edu
617-309-1957
Joslin Diabetes Center
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Unlocking jams in fluid materials
2. UNC researchers inch closer to unlocking potential of synthetic blood
3. Unlocking the secret of beauty: Scientists discover the complexities of attractive female bodies
4. Unlocking the Immune System's Response to Infection and Injury
5. CU-Boulder led study of smoking twins points to growing influence of genetic factors
6. Increasing dosage of clopidogrel for patients with genetic variation improves response to medication
7. Combination epigenetic therapy clinical trial results
8. Epigenetic therapy shows promise in hard-to-treat lung cancer
9. Breakthrough in understanding the genetics of high blood pressure
10. Possible Genetic Link to Autism Identified
11. Ohio State researchers design a viral vector to treat a genetic form of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unlocking the genetic and molecular mystery of soft-tissue sarcoma
(Date:4/23/2014)... pilot study by Massachusetts General Hospital (MGH) investigators may ... treatment for a serious medical problem use of ... caused by the Clostridium difficile ( C. ... online in the journal Clinical Infectious Diseases , ... material from donors unrelated to patients was as successful ...
(Date:4/23/2014)... Moffitt Cancer Center researchers say clinical trials for ... leukemia (AML) are very promising. Patients treated with ... and daunorubicin, are showing better responses than patients ... , "Acute myeloid leukemia is an aggressive ... success, especially in older patients," explained Jeffrey Lancet, ...
(Date:4/23/2014)... researcher is looking to give exercise enthusiasts the extra ... research shows that a cyber buddy can help. , ... Health Journal , is the first to indicate that ... during exercise, a software-generated partner also can be effective. ... real can still motivate people to give greater effort ...
(Date:4/23/2014)... - Purdue University researchers have developed a way to ... by using tiny gold particles with tails of synthetic ... agricultural and biological engineering, used gold nanoparticles to target ... BRCA1 messenger RNA splice variants, which can indicate the ... these mRNA splice variants in a cell can be ...
(Date:4/23/2014)... the gastro-intestinal tract has long been considered to be ... Sahlgrenska Academy have used refined microscopic techniques that indicate ... of the gastro-intestinal tract is only as large as ... The digestive tract, which passes from the mouth through ... length of about 5 meters in a normal adult, ...
Breaking Medicine News(10 mins):Health News:Use of frozen material for fecal transplant successfully treats C. difficile infection 2Health News:Use of frozen material for fecal transplant successfully treats C. difficile infection 3Health News:Moffitt Cancer Center's phase 3 study may be game-changer for acute myeloid leukemia 2Health News:Cyber buddy is better than 'no buddy' 2Health News:Gold nanoparticles help target, quantify breast cancer segments in a living cell 2Health News:The surface area of the digestive tract 'only' as large as a studio apartment 2
... remain stableWASHINGTON, Jan. 6 Karen Ignagni, President and CEO ... data released by CMS today showing that health spending in ... decade at 6.1 percent in 2007. According to the ... 2007, the same rate as in 2006, but much lower ...
... MAQUET Inc., a subsidiary of the Swedish-based ... largest surgical equipment companies in the world, has ... installation of its advanced, prefabricated VARIOP operating ... enables hospitals and surgical centers to reconfigure spaces ...
... University of California, San Francisco has received a $7.5 ... to address the shortage of healthcare workers in Tanzania. ... UCSF Global Health Sciences and the Muhimbili University of ... and document strategies to enable MUHAS and other African ...
... 6 For veterans struggling financially due to a job ... offers an assortment of programs that can relieve the costs ... "With the downturn in the economy, VA recognizes that many ... Dr. James B. Peake. "Therefore, it is important that eligible ...
... can cut down on pounds in middle age, study says ... less. , While it may sound painfully obvious, nutrition experts ... weight loss, because the practice can sometimes boomerang, triggering binge ... eating less can pay big dividends, particularly as you age. ...
... survey recently conducted by the Society of Corporate Compliance ... (HCCA) reveals that the declining economy may be increasing ... In addition, this increased risk is occurring at ... expected to at best hold steady, if not decline.The ...
Cached Medicine News:Health News:AHIP Statement on National Health Expenditure Data 2Health News:MAQUET opens North America's first VARIOP prefabricated operating suite system 2Health News:UCSF-Tanzania get $7.5M from Gates Foundation for partnership to train African health workers 2Health News:It Pays to Eat Less as You Age 2Health News:Legal and Ethical Violations Risks Seen Rising, But Not Resources to Control the Risk 2Health News:Legal and Ethical Violations Risks Seen Rising, But Not Resources to Control the Risk 3
(Date:1/15/2014)... Texas , Jan. 15, 2014  Novation, the leading ... awarded several new IT value-added reseller (VAR) national contracts ... IT goods and services at lower costs. These include ... services such as initiative assistance and ongoing IT consulting ...
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces that ... to the announced tender offer for all of the outstanding shares ... of the waiver, the transaction is no longer conditional on OFT ... 24, 2014 following the currently scheduled expiration time, subject to the ...
(Date:1/15/2014)... LOUISVILLE, Ky. , Jan. 15, 2014  Manufacturers, ... technologies must be able to protect their most ... (Logo: http://photos.prnewswire.com/prnh/20130716/CL46586LOGO ) Because ... Industry, it steadfastly remains one of the most ...
Breaking Medicine Technology:New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Intellectual Property Insurance for Medical-related Products and Services 2
... Nov. 10, 2011 The Medical Oncology Association ... Solutions recently signed an agreement to work together ... the quality and costs of cancer care in ... provides clinical, reimbursement and distribution services to help ...
... DENVER, Nov. 10, 2011 The American Society of Bariatric ... Bubba Smith.  Our condolences go out to his family, friends ... the medication phentermine was a contributing factor to his death ... using such medications as prescribed. While the ...
Cached Medicine Technology:Medical Oncology Association of Southern California, Cardinal Health Specialty Solutions Collaborate With Payors to Improve Quality, Costs, Accessibility of Cancer Care 2Medical Oncology Association of Southern California, Cardinal Health Specialty Solutions Collaborate With Payors to Improve Quality, Costs, Accessibility of Cancer Care 3Physicians Who Treat Obesity Respond to the News of Bubba Smith's Overdose 2
... for use with GIA DST ... with Titanium Staples)., ,The ... and the SGIA™ Knifeless Stapler ... pediatric and thoracic surgical procedures ...
The Reusable Purse String Clamp is intended for use in the mechanical construction of a purse string suture. The clamp can be used on any part of the gastrointestinal tract except the esophagus....
... Device for use with VALTRAC™ ... Ring)., ,The Purstring™ Device ... and esophageal surgery for the ... and is intended for use ...
... to create an automatic purse-string with ... 45 disposable instrument has application in ... surgery for temporary and permanent purse-string ... disposable instrument has application in intestinal, ...
Medicine Products: