Navigation Links
Unlocking the Immune System's Response to Infection and Injury
Date:6/16/2010

Scientists at The Feinstein Institute for Medical Research, in collaboration with colleagues at the Karolinska Institute, have identified the protein signals at the heart of infection and/or injury, a finding that offers hope for the development of new drugs that selectively block this pathway and prevent sickness syndromes.

Manhasset, NY (Vocus) June 16, 2010 -- It is termed “sickness syndrome,” the clinical response to injury or infection, which includes fever, weight loss, behavioral withdrawal and inflammation. Although it has been known for years that toxins associated with infectious agents can produce this syndrome, until now it has been a mystery as to why patients develop nearly identical clinical signs after sterile injury, absent infection. Scientists at The Feinstein Institute for Medical Research, in collaboration with colleagues at the Karolinska Institute, have identified the protein signals at the heart of this response, a finding that offers hope for the development of new drugs that selectively block this pathway and prevent sickness syndromes.

The study is published in the latest issue of the Proceedings of the National Academy of Sciences.

Feinstein President Kevin J. Tracey, MD, Karolinska’s Ulf Andersson, MD, and colleagues at both institutions have been mining the immune system pathways that play a critical role in the body’s response to infection and trauma. The pathophysiological response that results in sickness syndrome is mediated by cytokines, molecules that ignite an inflammatory immune response. Most of the time it is a measured response to the conditions at hand, but sometimes the system goes awry and sends out too many inflammatory foot soldiers. The results can be disastrous. Understanding how this process works should lead to effective treatments to prevent sepsis and similar conditions.

In the latest study, Dr. Tracey and his colleagues followed the path of an important cytokine called high-mobility group box 1 (HMGB1,) a housekeeping protein that stimulates the release of other cytokines in response to infection or injury. According to the latest study, HMGB1, which is released during both infection and sterile injury, selectively binds and signals through Toll-like receptor 4 (TLR4), an essential component of the immune system that sets in motion the release of other cytokines which produce sickness syndrome. Surprisingly, they also found that the interaction between these two central proteins (HMGB1 and TLR4) requires a single cysteine, because when they substituted this amino acid for another, the signals leading to cytokine release were blocked.

“These results have implications for the rational design and development of experimental therapeutics for use in sterile and infectious inflammation, because the molecular nature of the interaction is localized to a very small region, encompassing a single amino acid,” the authors wrote. Dr. Tracey added: “This is encouraging for future clinical trials, which are needed to block HMGB1 and stop it from interacting with TLR4 in order to prevent sickness syndrome.”

About The Feinstein Institute for Medical Research: Headquartered in Manhasset, NY, The Feinstein Institute for Medical Research is home to international scientific leaders in Parkinson's disease, Alzheimer’s disease, psychiatric disorders, rheumatoid arthritis, lupus, sepsis, inflammatory bowel disease, diabetes, human genetics, leukemia, lymphoma, neuroimmunology, and medicinal chemistry. The Feinstein Institute, part of the North Shore-LIJ Health System, ranks in the top 6th percentile of all National Institutes of Health grants awarded to research centers. Feinstein researchers are developing new drugs and drug targets, and producing results where science meets the patient. For more information, please visit www.FeinsteinInstitute.org or http://feinsteininstitute.typepad.com/feinsteinweblog/

Contact: Jamie Talan, science writer-in-residence
516-562-1232
###


Read the full story at http://www.prweb.com/releases/Feinstein_Institute/Infection_Injury/prweb4154434.htm.


'/>"/>
Source: PRWeb
Copyright©2010 Vocus, Inc.
All rights reserved  

Related medicine news :

1. Unlocking the Secrets to a Healthier Body
2. Organ Transplant Drug Keeps Immune System in Check
3. Immune memory formation seen in early stages of viral infection
4. Immune Deficiency Foundation Praises ACHDNC Recommendation for SCID Screening in Newborns
5. Immune Response Better With Skin Scratch Vaccination
6. Cancer stem cells suppress immune response against brain tumor
7. DNA Test May Detect Immune Disorder in Infants
8. The Chopra Center for Wellbeing Launches Vedamune: An Ayurvedic Supplement to Support The Immune System
9. Reportlinker Adds The Future of Autoimmune Diseases Therapeutics - Market Forecasts to 2015, Competitive Benchmarking, Product Pipeline and Deals Analysis
10. Immune cell activity linked to worsening COPD
11. Free Sample of Proven Health Mushroom Supplement Offered By ImmuneResponse247.com
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unlocking the Immune System's Response to Infection and Injury
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their ... Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. , ... Pro X users can now reveal the media of their split screens with ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, and ... in the eye of the beholder, according to experts who offered insights and commentary ... of Managed Care. For the full issue, click here . , For the ...
(Date:6/26/2016)... Lake Orion, Clarkston, Michigan (PRWEB) , ... June ... ... direction with respect to fertility once they have been diagnosed with endometriosis. These ... tolerable intercourse but they also require a comprehensive approach that can help for ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... ... the United States, named Dr. Sesan Ogunleye, as the Medical Director of its new ... the facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... 24, 2016 Research and ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" report ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, ... Structural electronics involves electronic and/or electrical components ... replacing dumb structures such as vehicle bodies or ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
Breaking Medicine Technology: