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Unlocking mysteries of brain cancer, stroke
Date:4/4/2008

nervous system, because the blood-brain barrier should normally prevent any cells including cancer cells from infiltrating the brain.

We will examine whether neuropeptides play any role in enabling these cancerous cells to cross the blood-brain barrier and facilitate secondary tumour development, Professor Vink says.

This year, the Centre for Neurological Diseases has also begun two new research projects investigating the role that a specific neuropeptide known as substance P can play in helping to prevent injury and death in victims of stroke. Substance P is a neurotransmitter and modulator that appears to be connected with brain haemorrhage.

These haemorrhages exacerbate the injury caused by stroke or brain trauma and are known to significantly increase mortality and worsen outcome in survivors. However, the mechanisms associated with how this exacerbation occurs are still unknown, Professor Vink says.

Our lab has evidence to suggest that substance P may play a major role in the injury process, and the use of antagonists which act to block substance P may therefore be highly beneficial in improving a patient's outcome.


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Contact: Robert Vink
robert.vink@adelaide.edu.au
61-883-034-533
University of Adelaide
Source:Eurekalert

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