Navigation Links
Unlocking mysteries of brain cancer, stroke
Date:4/4/2008

New studies at the University of Adelaide, Australia, will delve into some of the crucial issues surrounding death by brain tumours and stroke.

The research, to be conducted in the joint University of Adelaide/IMVS Centre for Neurological Diseases, will aim to find links between chemical signals in the brain and the reasons why brain tumours or strokes become fatal.

There are still many mysteries around how the brain works, and this new research will help to unlock key elements we believe are involved in two separate but equally debilitating conditions, says Professor Robert Vink, Head of the University's School of Medical Sciences and NRF Chair of Neurosurgical Research.

Brain tumours account for approximately 2% of all cancer deaths. However, a much greater problem is the spread of cancer, with secondary tumours developing within the central nervous system. This accounts for almost 10 times as many deaths as primary brain tumours.

For the first time, the Centre for Neurological Diseases will begin studies of brain tumours focusing on two specific research questions. The first is concerned with the oedema (swelling) caused in neural tissue by tumours, which plays a major role in patient mortality.

We know that the cerebral blood vessels in the vicinity of the tumour become leaky, and this is what underlies the development of the swelling. However, the mechanism that causes this change in vascular permeability is unknown, Professor Vink says.

From our research into traumatic brain injury and stroke, we believe that neuropeptides (chains of amino acids in the neural tissue) may play a key role in changing the permeability of the blood-brain barrier. This could also offer a novel therapeutic approach to managing the oedema caused by tumours, and therefore play an important part in helping to save patients lives, he says.

The second research question focuses on how cancerous cells enter the central nervous system, because the blood-brain barrier should normally prevent any cells including cancer cells from infiltrating the brain.

We will examine whether neuropeptides play any role in enabling these cancerous cells to cross the blood-brain barrier and facilitate secondary tumour development, Professor Vink says.

This year, the Centre for Neurological Diseases has also begun two new research projects investigating the role that a specific neuropeptide known as substance P can play in helping to prevent injury and death in victims of stroke. Substance P is a neurotransmitter and modulator that appears to be connected with brain haemorrhage.

These haemorrhages exacerbate the injury caused by stroke or brain trauma and are known to significantly increase mortality and worsen outcome in survivors. However, the mechanisms associated with how this exacerbation occurs are still unknown, Professor Vink says.

Our lab has evidence to suggest that substance P may play a major role in the injury process, and the use of antagonists which act to block substance P may therefore be highly beneficial in improving a patient's outcome.


'/>"/>

Contact: Robert Vink
robert.vink@adelaide.edu.au
61-883-034-533
University of Adelaide
Source:Eurekalert

Related medicine news :

1. Rutgers researchers unlock mysteries of vitamin A metabolism during embryonic development
2. Hospital Clinic awarded by CEREBRA Foundation for its excellence in early diagnosis of brain damage
3. Brain DNA remodeled in alcoholism
4. Small Brain Lesions More Common Than Thought in Those Over 60
5. How dangerous is boxing for the brain?
6. Are teenage brains really different?
7. Omega-3 Fatty Acids Protect the Spinal Cord, Heart, Brain and Eyes
8. Key factor in brain development revealed, offers insight into disorder
9. Study validates Pittsburgh Compound-B in identifying Alzheimers disease brain toxins
10. Brain scientist shedding light on learning, memory
11. Heart failure treated in the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... Dr. ... New York, has recently begun offering three new minimally invasive procedures to patients ... procedures and reducing downtime, Dr. Rubinstein is excited to bring microneedling, microneedling facials, ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ensuring meat ... new videos highlight the importance of correctly using a meat thermometer. The videos ... done extensive research on consumer food safety habits. Dr. Bruhn explains the variety ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ross Insurance Agency ... the Federal Emergency Management Agency’s (FEMA) recent update of flood zones, more people ... the Biggert-Waters Act was enacted to reflect the actual risk in flood zone ...
(Date:6/23/2017)... ... June 23, 2017 , ... All-Star Insurance, a family managed agency that offers ... Texas, is announcing the launch of a new charity drive to benefit women in ... United States reveal that an estimated 252, 710 new cases of invasive or high ...
(Date:6/22/2017)... ... June 22, 2017 , ... United Benefit Advisors ... Whipple & Company as its newest Partner Firm. Headquartered in Coconut Creek, Florida, ... risk while tailoring optimized benefit packages that strengthen the relationship between employer and ...
Breaking Medicine News(10 mins):
(Date:6/12/2017)... 12, 2017 Kineta, Inc., a biotechnology company focused ... Vice President of R&D and Head of Virology Kristin ... Preparedness for the Northwest and Beyond meeting sponsored by ... 14, 2017 from 8:30-10:30 AM PDT at the Agora Conference ... Dr. Bedard will be joined by other leaders in ...
(Date:6/9/2017)... PALO ALTO, Calif. , June 9, 2017 /PRNewswire/ ... medical device company focused on the design, manufacture, sale ... updated the market on the progress of its commercial ... AeroForm is now available in more than one hundred ... country. AeroForm offers a needle-free alternative ...
(Date:6/8/2017)... Responding to Heath Ledger,s father,s recent call for ... Chris Cornell in May, the mental health watchdog group, ... psychiatric drug side effects search engine ... risks. The father of the late actor ... has called for tighter rules on prescription drugs. Speaking at ...
Breaking Medicine Technology: