Navigation Links
University of Pittsburgh researchers crack code of 3-D structure in key metabolic protein
Date:3/10/2008

PITTSBURGH, March 10 Using X-ray crystallography, researchers at the University of Pittsburgh School of Medicine led by structural biologist Joanne I. Yeh, Ph.D., have become the first to decipher the three-dimensional structure of a membrane-bound enzyme that plays a crucial role in glycerol metabolism a discovery that could lead to important advances against obesity, diabetes and a potential host of other diseases. Their findings are reported in the March 4 issue of the Proceedings of the National Academy of Sciences.

The sugar-alcohol glycerol is an essential source of energy that is required to help drive cellular respiration. In addition to powering some of the most central reactions of the body, glycerol also provides key precursors needed to regulate fatty acid and sugar metabolism. Figuring out the complex ways that cells break down or produce glycerol and use this vital chemical could be critical to combating obesity, diabetes and other chronic disorders. Recent findings also have linked glycerol metabolism to cellular processes related to aging, infectivity in certain organisms such as Mycobacterium tuberculosis, and in other energy-related illnesses.

Everybody wants a golden bullet for obesity, and certainly we need better ways of controlling diabetes, said Dr. Yeh, the studys senior author and associate professor of structural biology at Pitt. I think that glycerol metabolism will be on the forefront of developing treatments for these diseases, and so many others, since it is a pivotal yet underappreciated link among some very important metabolic pathways.

The protein structure Dr. Yehs team solved is a large enzyme called Sn-glycerol-3-phosphate dehydrogenase known simply as GlpD found in abundance in the cell membranes of almost all organisms, including humans. GlpD is a monotopic membrane protein, which means that although it is embedded partially into the cell membrane, the protein does not span the entire membran
'/>"/>

Contact: Michele Baum
BaumMD@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Case Western Reserve University researchers identify colorectal cancer gene
2. New research from the University of Bristol aims to eliminate Streptococcus infections
3. Iowa State University researcher identifies eye disease in canines
4. Robert H. Smith Feeding the Future with $15 Million Gift to Hebrew University of Jerusalem
5. AT&T Provides In-Building Wireless Services to Thomas Jefferson University and Hospital
6. St. Louis University Hospital Purchases Second CyberKnife(R) System
7. Loma Linda University Medical Center Celebrates Groundbreaking on Inland Empires Most Comprehensive Rehabilitation Center
8. Alimera Sciences Signs Second Agreement With Emory University for Potential Treatments Using New Class of Antioxidants
9. University of Sydney researchers find new evidence linking kava to liver damage
10. University of Denver bullying victimization study
11. The Northern Illinois University Murders Due to Chemical Imbalances or Chemical Balancers - Drugs? - Fred A. Baughman Jr., MD, Neurologist/Child Neurologist
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Controlled application of vacuum pressure is a promising approach ... suggests an experimental study in the August issue of ... Congress of Neurological Surgeons . The journal is ... part of Wolters Kluwer Health . , ... injured area of the brainshows promise as a safe ...
(Date:7/31/2014)... and Las Vegas, Nevada (PRWEB) July 31, 2014 ... LaunchKey to provide next generation authentication services to cloud ... secure way to utilize hardware protected multi-factor authentication with ... in the Internet's reliance on password-based authentication. It is ... global data breaches taking place around the globe. Instead ...
(Date:7/31/2014)... Texas (PRWEB) July 31, 2014 The ... Patient Experience Executive Board and four new members ... strengthening its role as the global community of practice ... in healthcare. , Executive board members are industry ... plans, and provide valuable insight into market and industry ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Web Programming ... ISO 9001:2008 certified internet marketing firm, has recently launched ... to make this service affordable for everyone, the company ... the service. , Web Programming Services has tailored ... world of brochure designing and likely expectations of the ...
(Date:7/31/2014)... Steven Reinberg HealthDay Reporter ... Strict regulation of electronic cigarettes isn,t warranted based on ... the contrary, allowing e-cigarettes to compete with regular cigarettes ... after reviewing 81 prior studies on the use and ... evidence suggests that there is a potential for smokers ...
Breaking Medicine News(10 mins):Health News:Vacuum treatment may limit damage after traumatic brain injury 2Health News:Rivetz Partners with LaunchKey to Offer Next Generation Authentication for Accounts Leveraging Trusted Execution Technology. 2Health News:Rivetz Partners with LaunchKey to Offer Next Generation Authentication for Accounts Leveraging Trusted Execution Technology. 3Health News:The Beryl Institute Announces Seven New Patient Experience Board Members 2Health News:The Beryl Institute Announces Seven New Patient Experience Board Members 3Health News:Web Programming Services Introduces Affordable Brochure Designing Service 2Health News:Benefits of E-Cigarettes May Outweigh Harms, Study Finds 2Health News:Benefits of E-Cigarettes May Outweigh Harms, Study Finds 3
... trigger urge to smoke, researchers say , WEDNESDAY, Sept. 9 ... component in cigarettes, "tricks" the brain into creating memory associations ... why former smokers miss lighting up when they are in ... from researchers at Baylor College of Medicine are in the ...
... response , WEDNESDAY, Sept. 9 (HealthDay News) -- Early day ... and illnesses at an early age, thereby protecting them from ... the ,hygiene hypothesis," but a new study casts doubt on ... asthma and allergy rates at age 8. , An unexplained ...
... , SOUTHFIELD, Mich., Sept. 9 The Wild ... employee health screenings. While national and local regulations cover finger sticks ... national standards and monitors on-site health screenings or flu shot programs. ... approaches, a new white paper from wellness screening provider Summit Health, ...
... PRINCETON, N.J., Sept. 9 From October 5-9, contact center ... Mandalay Bay Convention Center to attend the sixth annual 2009 ... Produced by the International Customer Management Institute (ICMI), this year,s ... the Customer Experience." Intensive, daylong pre-conference summits for financial services ...
... , CHICAGO, Sept. 9 Morrisey ... high-risk, complex patients outside the acute-care setting. , ... (MCCM(TM)) Continuum of Care software enables organizations to extend their ... are able to reduce unnecessary hospital admissions, emergency department visits ...
... , , , SHREVEPORT, La., ... set out on her life-finding mission with a book contract in her pocket. ... giant in Italy, she was just living. She had no notion that what ... , But life took this Louisiana-raised girl and her endearing ...
Cached Medicine News:Health News:Nicotine Plays Tricks on Brain: Study 2Health News:Day Care May Not Shield Kids From Asthma, Allergies 2Health News:Day Care May Not Shield Kids From Asthma, Allergies 3Health News:Summit Health Helps Employers Navigate the 'Wild West' of Flu Shots and Workplace Health Screenings 2Health News:Global Gathering for Contact Center Professionals to Focus On 'Thinking Forward - The Power of the Customer Experience' at ICMI's Annual Call Center Exhibition Conference and Expo, Oct. 5-9 in Las Vegas 2Health News:Global Gathering for Contact Center Professionals to Focus On 'Thinking Forward - The Power of the Customer Experience' at ICMI's Annual Call Center Exhibition Conference and Expo, Oct. 5-9 in Las Vegas 3Health News:Morrisey Associates Helps Healthcare Organizations Improve Patient Management Outside the Acute-Care Setting 2Health News:Exotic Adventure and Clean Food: The Adventure Cookbook 2
(Date:7/31/2014)... Ariz. , July 31 2014  Northsight Capital, ... has been named Chairman and CEO of the ... risk management, legal matters, business development and investment banking. ... the securities industry.  Before his career on Wall Street, ... Division of the U.S, Securities and Exchange Commission in ...
(Date:7/31/2014)...  Columbia Laboratories, Inc. (Nasdaq: CBRX ... results for the three and six-month periods ended ... results benefited from the contribution of the Molecular ... partially offset an anticipated and temporary decline in ... license renewal in one high-volume, high-margin market. Throughout ...
(Date:7/31/2014)... 31, 2014  Today,s Consumer Reports story on ... important reminder for consumers of the importance of ... initiatives such as the Acetaminophen Awareness Coalition,s (AAC) ... education campaign. Formed in 2010, the Coalition is ... consumer organizations dedicated to educating consumers on safe ...
Breaking Medicine Technology:Northsight Capital, Inc. Names Wall Street Veteran John Bluher, Former EVP And General Counsel Of Knight Trading Group, Chairman And CEO. 2Columbia Laboratories Reports Second Quarter 2014 Financial Results 2Columbia Laboratories Reports Second Quarter 2014 Financial Results 3Columbia Laboratories Reports Second Quarter 2014 Financial Results 4Columbia Laboratories Reports Second Quarter 2014 Financial Results 5Columbia Laboratories Reports Second Quarter 2014 Financial Results 6Columbia Laboratories Reports Second Quarter 2014 Financial Results 7Columbia Laboratories Reports Second Quarter 2014 Financial Results 8Columbia Laboratories Reports Second Quarter 2014 Financial Results 9Columbia Laboratories Reports Second Quarter 2014 Financial Results 10Columbia Laboratories Reports Second Quarter 2014 Financial Results 11Columbia Laboratories Reports Second Quarter 2014 Financial Results 12U.S. Health Coalition Calls for Continued Education on Acetaminophen, America's Most Common Drug Ingredient 2
... Nov. 17, 2011 Reportlinker.com announces that ... in its catalogue: Asia-Pacific ... http://www.reportlinker.com/p0336611/Asia-Pacific-Diagnostic-Imaging-Market-Outlook-to-2017.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=NoCategory ... Summary ...
... Biotherapeutics (OTC.BB: NWBO) (Northwest Bio) today announced $2.4 million ... as an agreement to purchase the first $3 million ... agreement for an equity facility of up to $25 ... http://photos.prnewswire.com/prnh/20110329/SF73084LOGO ) The $2.4 million ...
Cached Medicine Technology:Asia-Pacific Diagnostic Imaging Market Outlook to 2017 2Asia-Pacific Diagnostic Imaging Market Outlook to 2017 3Asia-Pacific Diagnostic Imaging Market Outlook to 2017 4Asia-Pacific Diagnostic Imaging Market Outlook to 2017 5Asia-Pacific Diagnostic Imaging Market Outlook to 2017 6Asia-Pacific Diagnostic Imaging Market Outlook to 2017 7Asia-Pacific Diagnostic Imaging Market Outlook to 2017 8Asia-Pacific Diagnostic Imaging Market Outlook to 2017 9Asia-Pacific Diagnostic Imaging Market Outlook to 2017 10Asia-Pacific Diagnostic Imaging Market Outlook to 2017 11Asia-Pacific Diagnostic Imaging Market Outlook to 2017 12Asia-Pacific Diagnostic Imaging Market Outlook to 2017 13Asia-Pacific Diagnostic Imaging Market Outlook to 2017 14Asia-Pacific Diagnostic Imaging Market Outlook to 2017 15Asia-Pacific Diagnostic Imaging Market Outlook to 2017 16Asia-Pacific Diagnostic Imaging Market Outlook to 2017 17Asia-Pacific Diagnostic Imaging Market Outlook to 2017 18Asia-Pacific Diagnostic Imaging Market Outlook to 2017 19Northwest Bio Announces Transactions for $5.4 Million in New Financing 2Northwest Bio Announces Transactions for $5.4 Million in New Financing 3
... 2000 Pipette is a synonym for pipetting ... robust design, and superior operating comfort. Its ... the measuring stroke and blow-out as well ... system ensures utmost accuracy and precision. Ejection ...
... Remels newest member of the Xpect family, Xpect ... and B in one rapid test. The simple-to-perform ... available in 20 minutes. ,The Remel Xpect family ... range of rapid, direct specimen tests that combine ...
Inquire...
Inquire...
Medicine Products: