Navigation Links
University of Pennsylvania study reveals inconspicuous hosts in the Lyme disease epidemic
Date:11/29/2007

PHILADELPHIA - A study led by a University of Pennsylvania biologist in the tick-infested woods of the Hudson Valley is challenging the widely held belief that mice are the main animal reservoir for Lyme disease in the U.S.

The paper, published in the Proceedings of the Royal Society B, demonstrates that chipmunks and two shrew species, not just mice, are the four species that account for major outbreaks.

According to the study, white-footed mice account for about a quarter of infected ticks. Short-tailed shrews and masked shrews were responsible for a quarter each and chipmunks for as much as 13 percent. According to the team, vaccination strategies aimed solely at mice are unlikely to bring the disease under control. Efforts to control Lyme disease and prevent its spread, the team said, must include strategies that account for multi-species carriers.

The majority of zoonotic diseases, those that can be transmitted from wild or domestic animals to humans, are generally assumed to have one natural animal host, Dustin Brisson, professor of biology in the School of Arts and Science at Penn, said. For Lyme disease, this host has been the white-footed mouse. Data are beginning to accumulate to suggest that the story is much more complex, mice being one of an assemblage of vertebrate species contributing to feeding ticks and transmitting B. burgdorferi. Deer, a popular culprit of the Lyme disease epidemic, play a rather minor role in transmitting the bacteria to feeding ticks, although they are a major cause of the elevated tick densities that are important for the spread of the disease to humans.

Borrelia burgdorferi sensu stricto, the bacterium that causes Lyme disease, is transmitted to humans by infected, blacklegged ticks. The ticks, infected as larvae during their first meal the blood of a vertebrate are middle men.

Mice were thought to be the primary natural reservoir of the disease because nearly 90 percent of ticks feeding on an infected mouse contract the disease, nearly twice as much as any other species. In addition, mice are common, conspicuous and easy to research in the field and in the lab, promoting their status as primary natural reservoir. Yet other factors, such as population densities and tick burdens of other disease-carrying species, led investigators to rethink mice as the principal reservoir species for the disease.

The team employed genetic and ecological data, including dynamics of an outer surface protein of Lyme disease that provides clues about how the disease was transmitted, to discover that mice feed only 10 percent of all ticks and 25 percent of B. burgdorferi-infected ticks in the northeastern Lyme disease endemic zone. Shrews feed 35 percent of all ticks and 55 percent of infected ticks.

Emerging zoonotic pathogens, the 132 infectious diseases that cross the line between animal and human species, like Lyme disease, are a constant threat to world health. The research team, focused on improving existing strategies to protect the public health, is promoting the notion that targeting a single host species, in this case the white-footed mouse, may have been a faulty assumption.

While public-health strategies to control Lyme disease in North America have focused on interrupting transmission between blacklegged ticks and white-footed mice, Lyme disease infects more than a dozen vertebrate species, any of which can infect feeding ticks and increase human Lyme disease risk.


'/>"/>

Contact: Jordan Reese
jreese@pobox.upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Related medicine news :

1. University of Iowa professor identifies new eating disorder
2. University of Wisconsin Hospitals and Clinics Complete System-Wide Conversion to Masimo SET Pulse Oximetry Technology
3. University of Texas Study Details Lengthy Payment Delays for Medicare Part D Prescription Drug Claims, Confirming Need for Legislative Fix
4. Tulane University to receive $14M for international HIV/AIDS program
5. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
6. Boston University School of Medicine researcher recipient of Memory Ride Grant
7. Loma Linda University Medical Center Selects Beryl to Manage Call Center Interactions for Womens Services Programs and Departments
8. Medina General Hospital and University Hospitals Agree to Pursue Affiliation
9. J.D. Power and Associates Reports: Hackensack University Medical Center Recognized as First Hospital to Achieve Distinction for Providing an Outstanding Inpatient Experience in All Four Service Areas
10. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
11. George Mason University professor receives $2.6 million NIH grant to study Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ... June 23, 2017 , ... All-Star Insurance, a family managed agency that offers ... Texas, is announcing the launch of a new charity drive to benefit women in ... United States reveal that an estimated 252, 710 new cases of invasive or high ...
(Date:6/22/2017)... Santa Rosa, CA (PRWEB) , ... June 22, 2017 , ... ... has been named as a Top Doctor for 2017. Each year, research and information ... the country. First winning the title in 2015, this marks the 3rd time that ...
(Date:6/22/2017)... ... ... Despite its pervasiveness, many physicians are unfamiliar with how best to treat ... practice. Now, however, a timely review has been published in the Journal of ... NeuP and educating preclinical scientists on its diagnosis and choice of treatment. , The ...
(Date:6/22/2017)... ... June 23, 2017 , ... ... fight against hunger on June 21, 2017, at the Emeryville Center of Community ... and malnutrition around the world. , Rise Against Hunger (formerly Stop Hunger Now) ...
(Date:6/20/2017)... ... June 20, 2017 , ... After months of negotiations, FaceCradle USA is proud to ... on Wednesday, June 21. , “Introducing our product on QVC is something we all worked ... our travel pillow to more than 90 million homes in the United States,” said FaceCradle ...
Breaking Medicine News(10 mins):
(Date:6/20/2017)... , June 19, 2017  Hill-Rom Holdings, Inc. (NYSE: ... call and webcast on Friday, July 28, 2017, beginning at ... Call Audio Only Dial-in information: To participate in the conference ... dial into the call at least 10 minutes prior to ... is 34090339.  Webcast: ...
(Date:6/14/2017)... Calif. , June 14, 2017 The ... the City of Fremont and ... of the bio-pharma industry in California ... technology, enabling executive networking, and fostering workforce development. The ... development and growth of start-ups, as well as small ...
(Date:6/10/2017)... Ala. , June 9, 2017  Shane K. Burchfield, DPM, ... recognized for excellence as a Podiatrist in Alabama ... Podiatry at Family First Foot Care. He brings over 20 years ... medicine, pain management and healthcare, to his role. ... First Foot Care, PC is pleased to welcome you ...
Breaking Medicine Technology: