Navigation Links
University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene
Date:2/17/2009

OTTAWA, Feb. 17 /PRNewswire/ - A University of Ottawa Heart Institute (UOHI) research team has unlocked the mechanism that turns on a weight-loss gene in muscle. A new UOHI study shows that the mechanism - a DNA sequence variant identified as rs2419621 - increases the activity levels of ACSL5, among the first genes associated with weight loss, and enables rapid weight loss in people who are dieting.

Heart Institute scientists working with The Ottawa Hospital Weight Management Clinic had previously identified the ACSL5 gene, which influences how quickly overweight people lose weight in response to diet. Unlocking the mechanism to activate this gene represents a major step forward in developing new treatments for chronic illnesses such as cardiovascular diseases and diabetes, which are increased as a consequence of obesity. Diet and exercise are both important in weight loss. But individual response to diet and exercise vary dramatically - something that has long perplexed medical professionals.

"Weight loss, especially among people who are dieting, is affected by several factors and we've long suspected that personal genetic makeup is a real influence. We are learning that genes which make you fat are not the same as the genes that help you lose weight. And now we can put our finger on just how the weight-loss gene is activated," said Alexandre Stewart, PhD, principal investigator of the Ruddy Canadian Cardiovascular Genetics Research Centre, UOHI.

The UOHI research is expected to lead to the development of therapies to fuel ACLS5 activity in people. Further, medical professionals will be able to identify people who won't respond to diet and target drug treatment to help them lose weight more quickly.

Details of the latest UOHI discovery were published online in the Journal of the Federation of American Societies for Experimental Biology (http://www.fasebj.org/cgi/content/abstract/fj.08-120998v) The research was undertaken by molecular biologists at UOHI's Ruddy Canadian Cardiovascular Genetics Centre, led by Alexandre Stewart, PhD, and Frederique Tesson, PhD.

UOHI scientists found that the people who carry the ACSL5 DNA variant are able to lose weight faster when following a low calorie diet than those who do not. About 33% Caucasians carry this genetic variant, as do 50% of Blacks, and 29% of Orientals.

Obesity and weight-related illness have been the focus of major scientific projects at UOHI and is part of a global drive to fight obesity. One UOHI research team led by Dr. Ruth McPherson has been investigating the genetics behind obesity - considered a serious risk factor for coronary artery disease. They are searching for patterns among obese people to help explain why one obese person suffers from heart disease or diabetes when an equally heavy person does not.

"We know that controlling obesity is hugely important in managing serious chronic disease such as heart disease and diabetes. But clearly we also know the problem is much more complex than just teaching people how to eat better and get more exercise. We need to understand the genetics and biology of obesity in order to individualize treatment," said Dr. McPherson, Director of the Lipid Clinic, UOHI.

About UOHI

The University of Ottawa Heart Institute is Canada's largest and foremost cardiovascular health centre dedicated to understanding, treating and preventing heart disease. We deliver high-tech care with a personal touch, shape the way cardiovascular medicine is practiced, and revolutionize cardiac treatment and understanding. We build knowledge through research and translate discoveries into advanced care. We serve the local, national and international community, and are pioneering a new era in heart health. For more information, visit www.ottawaheart.ca


'/>"/>
SOURCE Ottawa Heart Institute, University of Ottawa
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. University of Iowa professor identifies new eating disorder
2. University of Wisconsin Hospitals and Clinics Complete System-Wide Conversion to Masimo SET Pulse Oximetry Technology
3. University of Texas Study Details Lengthy Payment Delays for Medicare Part D Prescription Drug Claims, Confirming Need for Legislative Fix
4. Tulane University to receive $14M for international HIV/AIDS program
5. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
6. Boston University School of Medicine researcher recipient of Memory Ride Grant
7. Loma Linda University Medical Center Selects Beryl to Manage Call Center Interactions for Womens Services Programs and Departments
8. Medina General Hospital and University Hospitals Agree to Pursue Affiliation
9. J.D. Power and Associates Reports: Hackensack University Medical Center Recognized as First Hospital to Achieve Distinction for Providing an Outstanding Inpatient Experience in All Four Service Areas
10. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
11. George Mason University professor receives $2.6 million NIH grant to study Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... Fla. (PRWEB) , ... May 02, 2016 , ... ... fat,” wraps itself around major organs, such as the kidneys, liver and pancreas. ... Robert Drapkin, M.D ., a board-certified physician in Internal Medicine, Medical Oncology and ...
(Date:5/2/2016)... ... May 02, 2016 , ... According to an American Psychological Association ... sexually abused before the age of 18. Of those who survive, many still face ... others. , In her new book, Lyah! Lyah! Pants on Fyah!, she shares ...
(Date:5/2/2016)... ... , ... TeleMedCo™, a new company developing real time technology ... rapid diagnosis, triage and admission of patients leveraging IBM Watson’s software and healthcare ... the first time at GENBAND’s Perspectives16 conference. , TeleMedCo selected GENBAND’s Kandy ...
(Date:5/2/2016)... ... ... Dr. Jonathan Kulbersh of Carolina Facial Plastics isn’t surprised that Charlotte, NC, the city where ... 5 US Cities with the Highest Plastic Rates .” The other cities that made ... calculated using a survey by RealSelf and combining that data with the number ...
(Date:5/2/2016)... ... 2016 , ... For many artists, the act of blending paint is based ... a science. , Using the new, highly precise METTLER TOLEDO ML204T balance to ... and meaning to his works. What’s more, it has allowed him to recreate these ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... April 29, 2016 Acquisition ... Sciences, Product Development Capabilities in North ... Base . Indegene ( http://www.indegene.com ... the acquisition of Skura Corporation,s life science business. ... adaptive sales enablement technology for life science organizations ...
(Date:4/28/2016)... 2016  While Abbott,s announced purchase of St. ... repair and stent business, healthcare research firm Kalorama ... firmly into patient monitoring.  Kalorama said that patient ... areas, with double-digit growth expected the next 5 ... Remote Patient Monitoring . Abbott Laboratories agreed ...
(Date:4/28/2016)... , April 28, 2016 ... insights on healthcare, announced today that it has been ... Cool Vendor in Life Sciences, 2016, ... 2016.  The report focuses on life-science- oriented analytics, algorithms ... from patients and doctors, confirm medication ingestion, and analyze ...
Breaking Medicine Technology: