Navigation Links
University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene
Date:2/17/2009

OTTAWA, Feb. 17 /PRNewswire/ - A University of Ottawa Heart Institute (UOHI) research team has unlocked the mechanism that turns on a weight-loss gene in muscle. A new UOHI study shows that the mechanism - a DNA sequence variant identified as rs2419621 - increases the activity levels of ACSL5, among the first genes associated with weight loss, and enables rapid weight loss in people who are dieting.

Heart Institute scientists working with The Ottawa Hospital Weight Management Clinic had previously identified the ACSL5 gene, which influences how quickly overweight people lose weight in response to diet. Unlocking the mechanism to activate this gene represents a major step forward in developing new treatments for chronic illnesses such as cardiovascular diseases and diabetes, which are increased as a consequence of obesity. Diet and exercise are both important in weight loss. But individual response to diet and exercise vary dramatically - something that has long perplexed medical professionals.

"Weight loss, especially among people who are dieting, is affected by several factors and we've long suspected that personal genetic makeup is a real influence. We are learning that genes which make you fat are not the same as the genes that help you lose weight. And now we can put our finger on just how the weight-loss gene is activated," said Alexandre Stewart, PhD, principal investigator of the Ruddy Canadian Cardiovascular Genetics Research Centre, UOHI.

The UOHI research is expected to lead to the development of therapies to fuel ACLS5 activity in people. Further, medical professionals will be able to identify people who won't respond to diet and target drug treatment to help them lose weight more quickly.

Details of the latest UOHI discovery were published online in the Journal of the Federation of American Societies for Experimental Biology (http://www.fasebj.org/cgi/content/abstract/fj.08-120998v) The research was undertaken by molecular biologists at UOHI's Ruddy Canadian Cardiovascular Genetics Centre, led by Alexandre Stewart, PhD, and Frederique Tesson, PhD.

UOHI scientists found that the people who carry the ACSL5 DNA variant are able to lose weight faster when following a low calorie diet than those who do not. About 33% Caucasians carry this genetic variant, as do 50% of Blacks, and 29% of Orientals.

Obesity and weight-related illness have been the focus of major scientific projects at UOHI and is part of a global drive to fight obesity. One UOHI research team led by Dr. Ruth McPherson has been investigating the genetics behind obesity - considered a serious risk factor for coronary artery disease. They are searching for patterns among obese people to help explain why one obese person suffers from heart disease or diabetes when an equally heavy person does not.

"We know that controlling obesity is hugely important in managing serious chronic disease such as heart disease and diabetes. But clearly we also know the problem is much more complex than just teaching people how to eat better and get more exercise. We need to understand the genetics and biology of obesity in order to individualize treatment," said Dr. McPherson, Director of the Lipid Clinic, UOHI.

About UOHI

The University of Ottawa Heart Institute is Canada's largest and foremost cardiovascular health centre dedicated to understanding, treating and preventing heart disease. We deliver high-tech care with a personal touch, shape the way cardiovascular medicine is practiced, and revolutionize cardiac treatment and understanding. We build knowledge through research and translate discoveries into advanced care. We serve the local, national and international community, and are pioneering a new era in heart health. For more information, visit www.ottawaheart.ca


'/>"/>
SOURCE Ottawa Heart Institute, University of Ottawa
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. University of Iowa professor identifies new eating disorder
2. University of Wisconsin Hospitals and Clinics Complete System-Wide Conversion to Masimo SET Pulse Oximetry Technology
3. University of Texas Study Details Lengthy Payment Delays for Medicare Part D Prescription Drug Claims, Confirming Need for Legislative Fix
4. Tulane University to receive $14M for international HIV/AIDS program
5. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
6. Boston University School of Medicine researcher recipient of Memory Ride Grant
7. Loma Linda University Medical Center Selects Beryl to Manage Call Center Interactions for Womens Services Programs and Departments
8. Medina General Hospital and University Hospitals Agree to Pursue Affiliation
9. J.D. Power and Associates Reports: Hackensack University Medical Center Recognized as First Hospital to Achieve Distinction for Providing an Outstanding Inpatient Experience in All Four Service Areas
10. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
11. George Mason University professor receives $2.6 million NIH grant to study Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... ... The Smart Machine Age is here, and it’s disrupting everything. Not only could ... in the United States may be taken over by technology in the next five ... steamrolls over colleagues is drawing to a close. Success will belong to those who ...
(Date:2/24/2017)... ... ... With millions of Americans and people worldwide struggling with ... aware of our options and are empowered with strength and information throughout the ... newest edition of "Vision and Hearing" in USA Today, that will educate readers ...
(Date:2/24/2017)... ... February 24, 2017 , ... The narrative in “ Signal 8: ... ’s true account of his paramedic experiences. Schanssema describes the tragedies he saw, as ... attempts to overcome them. , Schanssema, initially unsure of the career path he wanted ...
(Date:2/24/2017)... ... 2017 , ... The California State University Institute for Palliative Care ... interested in palliative care education and research. The Symposium, “Innovate. Investigate. Educate: Advancing ... Diego on Sept. 28 and 29, 2017, on the campus of California State University ...
(Date:2/24/2017)... ... ... The International Association of Eating Disorders Professionals (iaedp) announces the 2017 top five ... art competition. Selected from 15 submissions from around the nation, the top five finalists ... iaedp Symposium, March 22 – 26 in Las Vegas. , This year, the competition ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Ind. , Feb. 24, 2017 Zimmer ... leader in musculoskeletal healthcare, will present at the Cowen ... at the Boston Marriott Copley Place on Tuesday, March ... A live webcast of the presentation can be ... archived for replay following the conference via Zimmer Biomet,s ...
(Date:2/24/2017)... Feb. 24, 2017 Physician General Dr. ... Alcohol Programs Jennifer Smith commended South Central ... for and using naloxone, a life-saving overdose reversal drug. ... a recovery specialist and overdose survivor who was saved ... "A significant part of fighting the opioid ...
(Date:2/24/2017)... 2017 The U.S. Food and Drug ... Kit, performed on the Pheno System. This is ... bloodstream infections and provide information about which antibiotics ... sensitivity). The test also reduces the amount of ... which can guide antibiotic treatment recommendations more quickly. ...
Breaking Medicine Technology: