Navigation Links
University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene
Date:2/17/2009

OTTAWA, Feb. 17 /PRNewswire/ - A University of Ottawa Heart Institute (UOHI) research team has unlocked the mechanism that turns on a weight-loss gene in muscle. A new UOHI study shows that the mechanism - a DNA sequence variant identified as rs2419621 - increases the activity levels of ACSL5, among the first genes associated with weight loss, and enables rapid weight loss in people who are dieting.

Heart Institute scientists working with The Ottawa Hospital Weight Management Clinic had previously identified the ACSL5 gene, which influences how quickly overweight people lose weight in response to diet. Unlocking the mechanism to activate this gene represents a major step forward in developing new treatments for chronic illnesses such as cardiovascular diseases and diabetes, which are increased as a consequence of obesity. Diet and exercise are both important in weight loss. But individual response to diet and exercise vary dramatically - something that has long perplexed medical professionals.

"Weight loss, especially among people who are dieting, is affected by several factors and we've long suspected that personal genetic makeup is a real influence. We are learning that genes which make you fat are not the same as the genes that help you lose weight. And now we can put our finger on just how the weight-loss gene is activated," said Alexandre Stewart, PhD, principal investigator of the Ruddy Canadian Cardiovascular Genetics Research Centre, UOHI.

The UOHI research is expected to lead to the development of therapies to fuel ACLS5 activity in people. Further, medical professionals will be able to identify people who won't respond to diet and target drug treatment to help them lose weight more quickly.

Details of the latest UOHI discovery were published online in the Journal of the Federation of American Societies for Experimental Biology ('/>"/>

SOURCE Ottawa Heart Institute, University of Ottawa
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. University of Iowa professor identifies new eating disorder
2. University of Wisconsin Hospitals and Clinics Complete System-Wide Conversion to Masimo SET Pulse Oximetry Technology
3. University of Texas Study Details Lengthy Payment Delays for Medicare Part D Prescription Drug Claims, Confirming Need for Legislative Fix
4. Tulane University to receive $14M for international HIV/AIDS program
5. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
6. Boston University School of Medicine researcher recipient of Memory Ride Grant
7. Loma Linda University Medical Center Selects Beryl to Manage Call Center Interactions for Womens Services Programs and Departments
8. Medina General Hospital and University Hospitals Agree to Pursue Affiliation
9. J.D. Power and Associates Reports: Hackensack University Medical Center Recognized as First Hospital to Achieve Distinction for Providing an Outstanding Inpatient Experience in All Four Service Areas
10. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
11. George Mason University professor receives $2.6 million NIH grant to study Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... (PRWEB) August 30, 2014 "My wife ... of a car accident," said one of two inventors ... strain in her shoulder and neck area. She tried ... reduced pain and pressure, assisting in comfort and providing ... patent-pending PILLOW CRADLE to support the head, neck and ...
(Date:8/30/2014)... Pittsburgh, PA (PRWEB) August 30, 2014 ... not sleep knowing that, at any moment, her fever ... "In order to keep me well aware of how ... He developed the TEMP ALARM to continuously monitor a ... child develops a fever. This ensures that prompt medical ...
(Date:8/30/2014)... 30, 2014 The federal judge ... ( http://www.injurybeacon.com/transvaginal-mesh/ ) filed against Boston Scientific Corp. ... cases selected for one of the proceeding’s bellwether ... 18, 2014, U.S. District Judge Joseph R. Goodwin ... with Boston Scientific’s contention that a consolidated trial ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 In today’s world, ... difficult to get. Snoring and sleep apnea (a medical problem ... people and their bed partners of the rest they need ... of the population snores and 20 million people in the ... have been diagnosed and treated; and of those treated, many ...
(Date:8/30/2014)... 30, 2014 Top10BestSEOHosting.com is a ... have announced that HostGator.com http://secure.hostgator.com/~affiliat/cgi-bin/affiliates/clickthru.cgi?id=seohosts is ... market. Also, they has announced that Bluehost and ... , Hostgator, one of the Top 10 Web ... cheap Windows hosting, and it offers rich features ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 3Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Top10BestSEOHosting.com: HostGator.com Is The Best Windows Hosting Supplier 2
... of Soy Trial (BEST), a Baltimore-based randomized controlled study ... pertaining to cholesterol reduction, metabolic syndrome, and recruitment for ... by Johns Hopkins University School of Nursing (JHUSON) researcher ... its findings this month in Menopause and Ethnicity and ...
... a condition that causes clogging and narrowing of the ... their walls. //Over a period of time, the plaque ... of arteries usually happens in adults. ,But, ... McMaster University in Hamilton, Ontario, have presented a report ...
... that lead to dehydration can signal a future attack for ... American// College of Rheumatology Annual Scientific Meeting in Washington DC. ... causes severe pain and swelling of the joints. The attacks, ... few days, most often the big toe, can also generate ...
... A new study published by CANCER (a peer-reviewed ... than 47% of the breast cancer patients met ... a psychiatric disorder, including major depression and post-traumatic ... virtually all of the women admitted have been ...
... Day is an opportune time to evaluate the support ... world coping with a galloping disease. Taking// cognizance of ... Care for Everyone, especially the disadvantaged and the vulnerable’ ... ,The global initiative in diabetes management seeks ...
... HIV infection among injection drug users in Taiwan has led ... year according to a// health official. ,Last ... only a 10th of the total budget for HIV programs, ... at Taiwan's Center for Disease Control. However, next year this ...
Cached Medicine News:Health News:Soy Protein Study Generates New Findings 2Health News:It's the Heat and the Humidity: How Each Worsens Gout Symptoms 2Health News:Breast Cancer Patients Suffer From Psychological Problems 2Health News:The Holy Grail of Diabetes Management 2Health News:The Holy Grail of Diabetes Management 3Health News:Surge of HIV Cases in Taiwan Prompts Doubling in Expenditure for HIV Prevention 2
(Date:8/29/2014)... -- Does your doctor know what you,re smoking?  Chances are, ... to the over 112,000 currently registered patients under ... other roughly 20,300+ active physicians listed with the Colorado Dept ... even though a poll in February 2014 showed 51% of ... it. "With marijuana legalization underway, every doctor ...
(Date:8/29/2014)... Md. , Aug. 29, 2014  United Therapeutics ... the U.S. District Court for the District of ... favor in the company,s case against Sandoz, Inc. regarding ... Peter Sheridan ruled that U.S. Patent No. ... and enjoined Sandoz from marketing its generic product until ...
(Date:8/29/2014)... , August 29, 2014 ... Market by Product & Services (Equipment, Reagent, Primer, ... Application (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, ... MarketsandMarkets, the global Oligonucleotide Synthesis Market is expected ... Million in 2014, growing at a CAGR of ...
Breaking Medicine Technology:Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4District Court Decision Received In Remodulin Patent Case 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4
Provides reliable information on the most commonly prescribed drugs, their side effects, interactions and cost of therapy....
... Handbook on Injectable Drugs is ... makes it quick and easy to ... Once you enter the selected drugs, ... displayed so you can quickly take ...
... Guide for Nurses with Integrated Calculators, based ... is a remarkable advance in drug reference. ... Davis s Drug Guide (9th Edition) and ... based medications. This product merges many of ...
Instant access to drug-drug and drug-food interaction between thousands of brand and generic drugs plus A to Z Drug Facts monographs. Includes free updates for one year....
Medicine Products: