Navigation Links
University of Minnesota researchers discover enzyme behind breast cancer mutations
Date:2/6/2013

MINNEAPOLIS/SAINT PAUL (February 6, 2013) Researchers at the University of Minnesota have uncovered a human enzyme responsible for causing DNA mutations found in the majority of breast cancers. The discovery of this enzyme called APOBEC3B may change the way breast cancer is diagnosed and treated.

The findings from a team of researchers led by Reuben Harris, Ph.D., associate professor of biochemistry, molecular biology and biophysics and also a researcher at the Masonic Cancer Center, University of Minnesota, are published in the latest edition of Nature.

"We strongly believe this discovery will change the way mutations in cancer are viewed and, hopefully, it will allow cancer researchers to develop new treatments approaches that can prevent these mutations before they become harmful," said Harris.

Harris' quest to learn more about mutations in cancer initially began with HIV research. This previous work by Harris' lab and others indicated that APOBEC3B and related enzymes function normally to protect from infectious viruses like HIV-1.

During these studies, Harris' team developed specific tests to quantify the expression of each of the seven APOBEC3 genes, including APOBEC3B.

Harris and his team were able to apply these tests to the problem of mutation in breast cancer, showing only APOBEC3B is over-expressed in patients' breast cancer cell lines and tumors.

"DNA mutations are absolutely essential for cancer development," said Harris. "Our experiments showed the APOBEC3B enzyme causes mutations in the genome of breast cancer cells. From this, we were able to reasonably conclude that the APOBEC3B is a key influencer in breast cancer."

However, Harris points out that APOBEC3B appears to be a biological "double-edged sword." It protects some cells from viruses such as HIV-1 yet produces mutations giving rise to cancer in others.

Harris stresses the need for additional research. If further studies confirm that high APOBEC3B levels indicate the early presence of breast cancer, a simple blood test could be a strategy for early detection.

Another goal for Harris is finding a way to block APOBEC3B from causing mutation, just as sunscreen prevents sun from causing mutations leading to melanoma. His collaborative HIV studies are already pointing toward such drug possibilities.

"Our next steps will focus on the connections between high levels of APOBEC3B, age and other genetic risk factors that are known breast cancer markers. Ultimately, we hope our discovery leads to better therapeutic outcomes for patients," said Harris.


'/>"/>

Contact: Matt DePoint
mdepoint@umn.edu
612-625-4110
University of Minnesota Academic Health Center
Source:Eurekalert

Related medicine news :

1. University of California Irvine, Medical Center Selects Jvion as their ICD-10 Risk Assessment and Crosswalk Provider
2. Mainz University Medical Center receives further DFG funding for cardiovascular research
3. University of Tennessee researcher finds first time could predict sexual satisfaction
4. Lavender Languages Conference celebrates 20 years at American University
5. Spring Classes for Wexford University’s Online Doctoral Degree in Applied Sport Psychology Begin April 1
6. To Meet Growing Demand for Sports Psychology Experts, Wexford University Offers Master’s Degree in Applied Sport Psychology: Classes Begin April 1
7. Wexford University’s Master’s Degree in Nutrition and Exercises Prepares Weight Management Coaches and Consultants: Spring Quarter Launches April 1
8. Wayne State University researcher to evaluate success of text message diabetes intervention
9. University of Southern Mississippi Department of Marine Science Researches Marine Algae as Alternative Fuel Source
10. McGill University Launches a Major New Study on HPV Prevention Using Divine 9 Personal Lubricants with Carragel
11. Hospital of the University of Pennsylvania receives Comprehensive Stroke Center Certification
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Aliso Viejo, California (PRWEB) , ... June 27, 2016 , ... ... that are fully customizable inside of Final Cut Pro X," said Christina Austin - ... with another unique style. Final Cut Pro X users can now reveal ...
(Date:6/27/2016)... , ... June 27, 2016 , ... TopConsumerReviews.com recently awarded ... Eyeglasses . , Millions of individuals in the United States and Canada wear ... a way to both correct vision and make a fashion statement. Even celebrities use ...
(Date:6/26/2016)... Cary, North Carolina (PRWEB) , ... June 26, 2016 , ... ... the release of a new product that was developed to enhance the health of ... harvested for centuries. , The two main herbs in the PawPaws Cat Kidney ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... report to their offering. ... a favourable commercial environment for MedImmune to enter. The US ... will serve to drive considerable growth for effective anti-influenza medications. ... cap sales considerably, but development is still in its infancy. ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
Breaking Medicine Technology: