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University of Minnesota research finds key piece to cancer cell survival puzzle
Date:8/7/2014

y other tumor types," said Baird. "Thus, the discovery that Ligase 3 is required for this process is fundamentally important."

Interestingly, the research was made possible by a chance meeting between Hendrickson, who is an expert in using gene targeting to create cells missing key components (such as Ligase 3), and Baird, who is a leading expert in analyzing telomeres. When the two discovered at a scientific conference that they were both looking at the role of Ligase 3 in cancer, they decided to collaborate.

"The collaboration paid off as we were able to uncover something that neither one of us could have done on our own," Hendrickson says.

Importantly, additional studies are already underway. In particular, the reliance on Ligase 3 appears, in turn, to be dependent upon the activity of another key DNA repair gene, p53.

"Since p53 is the most commonly mutated gene in human cancer, it now behooves us to discover how these two genes are interacting and to see if we can't use that information to develop synergistic treatment modalities," says Hendrickson.


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Contact: Stephanie Xenos
sxenos@umn.edu
612-624-8723
University of Minnesota
Source:Eurekalert

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