Navigation Links
University of Minnesota research finds key piece to cancer cell survival puzzle
Date:8/7/2014

An international team led by Eric A. Hendrickson of the University of Minnesota and Duncan Baird of Cardiff University has solved a key mystery in cancer research: What allows some malignant cells to circumvent the normal process of cell death that occurs when chromosomes get too old to maintain themselves properly?

Researchers have long known that chromosomal defects that occur as cells repeatedly divide over time are linked to the onset of cancer. Now, Hendrickson, Baird and colleagues have identified a specific gene that human cells require in order to survive these types of defects.

"We have identified a gene that, as cells age, seems to regulate whether the cells become cancerous or not," Hendrickson said. "This gene has never been identified before in this role, so this makes it a potentially very important therapeutic target."

As cells divide their telomeres the DNA "caps" that protect the ends of chromosomes from damage shorten, leaving the chromosomes vulnerable to sticking to each other. In normal cells, this chromosome stickiness is a death knell a signal to defective-cell cleanup crews to move in and finish them off. Malignant cells, however, are somehow able to elude the cleanup crews.

The current research, published in the August 7 issue of the journal Cell Reports, identifies an essential component that allows older cells to evade death. Using sophisticated gene-targeting techniques to disable particular genes in human cells and then studying the impact on telomere fusion, the researchers found that cells escaped death only when the gene Ligase 3 was active but not when its action, which appears to promote fusion within like chromosomes rather than between different chromosomes, was blocked.

"Telomere dysfunction has been identified in many human cancers, and as we have shown previously, short telomeres can predict the outcome of patients with [chronic lymphocytic leukemia] and probably man
'/>"/>

Contact: Stephanie Xenos
sxenos@umn.edu
612-624-8723
University of Minnesota
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Young Cancer Patients at Loma Linda University Children's Hospital Treated to an Afternoon of Fun with UCLA Football Players, Sponsored by Stater Bros
2. Drexel University College of Medicine Research May Lead to Improved Alzheimer’s/Vascular Dementia Diagnostic Guidelines
3. West Coast University Launches New Doctorate of Pharmacy Program
4. University of Florida Startup Launches Million-dollar Indiegogo Campaign to Eliminate Painful Needle Injections for Insulin
5. Frontier Nursing University Receives $700,000 in Scholarships for Advanced Practice Nursing and Midwifery Students
6. Frontier Nursing University Busts Midwifery Myths In Celebration of 75th Anniversary
7. MyMobileUniversity and Fortech International Form Strategic Alliance That Will Enhance the Global Health and Medical Channel on Its Website
8. MyMobileUniversity Inviting Individuals, Who Are Passionate about the Universal Right to Education, to Come on Board as Goodwill Ambassadors
9. National League for Nursing Congratulates League President Marsha Adams on Appointment as Dean of College of Nursing at University of Alabama-Huntsville
10. Vedic living in a modern world: International conference at Maharishi University
11. New network unites university health care research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... Myoderm announced today the ... their CentralSource service. Matthew will play ... drug sourcing, distribution, and management service for international ... of industry experience, in both business development and ... their international success to help clients manage their ...
(Date:10/20/2014)... Collins, CO (PRWEB) October 20, 2014 ... dGH assays are the only imaging assays capable ... in a single test.  With these three dimensions ... their ability to detect the widest range of ... translocations—mutations usually missed by other genomic tools, including ...
(Date:10/20/2014)... October 20, 2014 Unveiled at the Sept. ... Direction Scorecard conservatively estimates member hospital ROI on membership dues ... dues, The Center provides $12.50 in value to member hospitals. ... Value – Member Dues)/Member Dues. , “This is the ... number and we think the methodology is really sound,” said ...
(Date:10/20/2014)... Houston plastic surgeon Dr. Christopher Patronella ... his innovative True Form Tummy Tuck® method ... faculty at The University of Texas Medical Branch ... a medical student. Patronella, who is a founding partner ... practices in Texas, The Aesthetic Center for Plastic ...
(Date:10/19/2014)... The leading review website, Top10BestSEOHosting.com, has recently ... are the best Dedicated Server Hosting suppliers. Their ... to buy high quality hosting and save money ... of Top10BestSEOHosting.com says, “We believe that iPage and ... A lot of the global clients enjoy using ...
Breaking Medicine News(10 mins):Health News:Myoderm Hires Matthew Voicheck to Lead Turnkey Drug Sourcing Service 2Health News:KromaTiD Launches Genome Screening and Discovery Services 2Health News:KromaTiD Launches Genome Screening and Discovery Services 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 2Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 3Health News:Scorecard Estimates Hospital ROI at $12.50 for every $1 Spent on Dues 4Health News:Plastic Surgeon Patronella Presents Artistically-Inspired Tummy Tuck Method to Future Generation of Plastic Surgeons in Texas 2Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2
... ,KO Cancer, with Susan G. Komen for the Cure, ... boxers,Felix "Tito" Trinidad and Roy Jones Jr. -- who will ... Jan. 19 -- have teamed with Susan G.,Komen for the ... activists, to help educate and raise awareness regarding the,deadly disease., ...
... diagnostic imaging, BLOOMINGTON, Minn., Dec. 21 ... efficiency of care reduced,medical expenses by $74 million ... introduced in February, reduced unnecessary,tests by more than ... from the American College of Radiology to confirm ...
... BROOK, Ill. December 21, 2007 The ... for the role of endoscopy in treating dyspepsia, discomfort ... a fourth of the population in Western countries. ... instrument to evaluate the inside of the esophagus, stomach ...
... for 2007, CONCORD, Ontario, Dec. 21 ... ,OTG, ,the Company,), a,leading multi- industry computer hardware, ... received an order for 100TB SAN dedicated,to pioneering ... oncology hospitals. The EqualLogic iSCSI SAN order is ...
... HLS ) announced today that its Board of Directors ... on its 6.5%,Series A Convertible Perpetual Preferred Stock, payable ... 2, 2008., About HealthSouth, HealthSouth is the ... states across the country and in,Puerto Rico, HealthSouth serves ...
... by Dr. Steve Bailey, an internationally recognized sports historian, ... the beginnings, achievements and events that shaped the Paralympic ... Movement and other able-bodied sports. , In addition ... First establishes key players in administration and sports politics, ...
Cached Medicine News:Health News:Don King Enlists Prizefighters Felix 'Tito' Trinidad and Roy Jones Jr. to Strike a Blow against Breast Cancer 2Health News:Don King Enlists Prizefighters Felix 'Tito' Trinidad and Roy Jones Jr. to Strike a Blow against Breast Cancer 3Health News:HealthPartners Reports 2007 Most Cost Effective Programs Reduce Expenses by $74 Million 2Health News:ASGE offers guidelines on endoscopic treatment of dyspepsia 2Health News:ASGE offers guidelines on endoscopic treatment of dyspepsia 3Health News:On The Go Ships 100TB Hardware Order for Ground-Breaking Cancer Imaging and Therapy Projects 2Health News:On The Go Ships 100TB Hardware Order for Ground-Breaking Cancer Imaging and Therapy Projects 3Health News:HealthSouth Declares Dividend on 6.5% Series A Convertible Perpetual Preferred Stock 2Health News:First reputable book on the history of the Paralympic Movement 2
(Date:10/17/2014)... , Oct. 17, 2014 UBM Medica US announces ... leading online community and information resource for neurologists and other ... and Alzheimer disease , with discussions of the latest ... 1 million Americans have Parkinson disease , more than the ... Lou Gehrig disease. Diagnosis can be difficult because ...
(Date:10/17/2014)... -- A victim of medical negligence at the hands of ... history of alcohol abuse, a physician and consumer advocates unveiled ... highlighting how Prop 46 will identify and deter physician substance ... The ad pictures a doctor drinking at a bar as ... will enact the first law in the nation requiring random ...
(Date:10/17/2014)... Inc ., reported on results of 59 glaucoma patients treated ... to 3 years with the InnFocus MicroShunt® at the 2014 ... . The Summit was held prior ... American Academy of Ophthalmology . The Company also said it ... countries by early 2015. Logo - http://photos.prnewswire.com/prnh/20141016/152617LOGO ...
Breaking Medicine Technology:Neurology Times Features Coverage of Parkinson and Alzheimer Disease 2Neurology Times Features Coverage of Parkinson and Alzheimer Disease 3Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 2Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 3Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 4InnFocus Featured at the Ophthalmology Innovation Summit In Chicago 2
All-silicone construction provides maximum softness and biocompatibility for enhanced patient comfort. Supplied sterile in peel-open packages. Intended for one-time use....
The 100% Silicone construction is ideal for pediatric and latex-sensitive patients....
BARDEX Red Rubber Urethral Catheter (Robinson Model)...
Used for injection into urethral strictures, bladder neck contracture, and the bladder wall. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: