ANN ARBOR, Mich. A potent new inhibitor of HIV, derived from bananas, may open the door to new treatments to prevent sexual transmission of HIV, according to a University of Michigan Medical School study published this week.
Scientists have an emerging interest in lectins, naturally occurring chemicals in plants, because of their ability to halt the chain of reaction that leads to a variety of infections.
In laboratory tests, BanLec, the lectin found in bananas, was as potent as two current anti-HIV drugs. Based on the findings published March 19 in the Journal of Biological Chemistry, BanLec may become a less expensive new component of applied vaginal microbicides, researchers say.
New ways of stopping the spread of the HIV are vitally needed. The rate of new infections of HIV is outpacing the rate of new individuals getting anti-retroviral drugs by 2.5 to1, and at present it appears an effective vaccine is years away.
"HIV is still rampant in the U.S. and the explosion in poorer countries continues to be a bad problem because of tremendous human suffering and the cost of treating it," says study senior author David Marvovitz, M.D., professor of internal medicine at the U-M Medical School.
Although condom use is quite effective, condoms are most successful in preventing infection if used consistently and correctly, which is often not the case.
"That's particularly true in developing countries where women have little control over sexual encounters so development of a long-lasting, self-applied microbicide is very attractive," Markovitz says.
Some of the most promising compounds for inhibiting vaginal and rectal HIV transmission are agents that block HIV prior to integration into its target cell.
The new research describes the complex actions of lectins and their ability to outsmart HIV. Lectins are sugar-binding proteins. They can identify foreign invaders, like a virus,
|Contact: Shantell M. Kirkendoll|
University of Michigan Health System