Navigation Links
University of Michigan scientists discover bone marrow can harbor HIV-infected cells
Date:3/8/2010

ANN ARBOR, Mich. University of Michigan scientists have identified a new reservoir for hidden HIV-infected cells that can serve as a factory for new infections. The findings, which appear online March 7 in Nature Medicine, indicate a new target for curing the disease so those infected with the virus may someday no longer rely on AIDS drugs for a lifetime.

"Antiviral drugs have been effective at keeping the virus at bay. However once the drug therapy is stopped, the virus comes back," says senior author of the study Kathleen L. Collins, M.D., Ph.D., associate professor of both internal medicine and microbiology and immunology at the U-M Medical School.

In people infected with HIV (human immunodeficiency virus), the virus that causes AIDS, there's an unsolved problem with current anti-viral drugs. Though life-saving, they cannot root the virus out of the body. Infected cells are able to live on, undetected by the immune system, and provide the machinery for the virus to reproduce and spread.

Important new research by U-M has discovered that bone marrow, previously thought to be resistant to the virus, can contain latent forms of the infection. They are not affected by current anti-HIV drug regimens.

"This finding is important because it helps explain why it's hard to cure the disease," Collins says. "Ultimately to cure this disease, we're going to have to develop specific strategies aimed at targeting these latently infected cells."

"Currently people have to take anti-viral drugs for their entire life to control the infection," she says. "It would be easier to treat this disease in countries that don't have the same resources as we do with a course of therapy for a few months, or even years. But based on what we know now people have to stay on drugs for their entire life."

Using tissue samples, U-M researchers detected HIV genomes in bone marrow isolated from people effectively treated with antiv
'/>"/>

Contact: Shantell M. Kirkendoll
smkirk@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. University of Iowa professor identifies new eating disorder
2. University of Wisconsin Hospitals and Clinics Complete System-Wide Conversion to Masimo SET Pulse Oximetry Technology
3. University of Texas Study Details Lengthy Payment Delays for Medicare Part D Prescription Drug Claims, Confirming Need for Legislative Fix
4. Tulane University to receive $14M for international HIV/AIDS program
5. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
6. Boston University School of Medicine researcher recipient of Memory Ride Grant
7. Loma Linda University Medical Center Selects Beryl to Manage Call Center Interactions for Womens Services Programs and Departments
8. Medina General Hospital and University Hospitals Agree to Pursue Affiliation
9. J.D. Power and Associates Reports: Hackensack University Medical Center Recognized as First Hospital to Achieve Distinction for Providing an Outstanding Inpatient Experience in All Four Service Areas
10. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
11. George Mason University professor receives $2.6 million NIH grant to study Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... Angeldress.co.uk, the distinguished wedding dress manufacturer ... dress fans. The company has recently updated its official ... the holiday season, Angeldress Blog has recommended ... , Angeldress.co.uk prides itself in offering a huge selection ... All the company’s outfits are very carefully selected based ...
(Date:12/20/2014)... York, NY (PRWEB) December 20, 2014 The ... has caused quite a stir, not only in Hollywood, but ... on December 18th , the ripples of that attack are ... executives’ very jobs at risk. But they are not ... correspondences exposed could be in for some embarrassing times ahead, ...
(Date:12/20/2014)... Xarelto bleeding lawsuits filed by men ... and other serious side effects will be consolidated in ... coordinated pretrial proceedings, Wright & Schulte LLC reports. The ... order Friday to transfer 21 Xarelto lawsuits and over ... to the Louisiana district court for coordination by Judge ...
(Date:12/20/2014)... Today, Balfleet.com, one of the most outstanding dressmakers in ... on its Mother of the Bride Dresses ... bride dresses from Balfleet.com feature gorgeous looks and delicate ... pride in providing high quality dresses to its clients ... on our mother of the bride dresses, and we ...
(Date:12/19/2014)... Sweetdressy.com , a leading wedding dress manufacturer ... of cheap prom dresses for ladies worldwide. The prom ... and clients can buy these dresses at the website ... cool cuts and delicate craftsmanship, and most of them ... Discount shipping costs are available for all of their ...
Breaking Medicine News(10 mins):Health News:Trendy Professional Wedding Apparel Recommended by Angeldress Blog 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 3Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 5Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 2Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 3Health News:Xarelto Bleeding Lawsuits Consolidated To Louisiana Federal Court For Multi-District Litigation Reports Wright & Schulte LLC 4Health News:Balfleet.com is Offering 50%-70% Off of its Mother of the Bride Dresses 2Health News:Cheap Prom Dresses Online Now at Sweetdressy.com 2
... in midlife underreport the number of hot flashes that they ... are linked to poor verbal memory, according to a study ... The study is published online and will appear in the ... is the first study to explore the relationship between objectively ...
... 16 The American,Association for Homecare (AAHomecare) applauded ... that will delay for at least 18 months ... home,medical equipment and services. The bill, H.R. 6252, ... of 2008.", The competitive acquisition or "competitive ...
... as surgery and pharmaceuticals were important to medicine in the ... the 21st century,and biofeedback is an important component of Behavioral ... Basmajian, Member ... One of the World,s Leading Sport,Psychologists that trained Canada,s top ...
... can lessen the cholesterol-lowering drugs, effectiveness , , MONDAY, June ... production of one protein helps explain why some people ... researchers report. , Statins include blockbuster medications such as ... as HMGCR, plays a critical role in production of ...
... where, but calls it ,most fruitful, lead in ongoing ... News) -- Although a U.S. government investigation into ... for the contamination, health officials said Monday they are ... nine cases in one location. , "The cluster ...
... Staff, and 7 other HFI usability, experts speak ... research topics including, ,Who are We ... YORK, June 16 Human Factors International (HFI),the ... "platinum",sponsorship of the 2008 Usability Professionals, Association International,Conference. ...
Cached Medicine News:Health News:Hot flashes underreported and linked to forgetfulness 2Health News:American Association for Homecare Applauds Bill to Delay the Flawed Medicare Bidding Program for Home Medical Equipment 2Health News:American Association for Homecare Applauds Bill to Delay the Flawed Medicare Bidding Program for Home Medical Equipment 3Health News:Biofeedback Workshops & Distance Learning Offer Credits and Training Options 2Health News:Research Shows Why Statins Don't Work for Everyone 2Health News:FDA Narrowing Tainted Tomato Probe to One Cluster 2Health News:FDA Narrowing Tainted Tomato Probe to One Cluster 3Health News:Human Factors International Sponsors Usability Professionals' Association (UPA) 2008 International Conference 2Health News:Human Factors International Sponsors Usability Professionals' Association (UPA) 2008 International Conference 3
(Date:12/17/2014)... , The new Dompé website aims ... the biopharmaceutical Group,s national and international clinical research activities ... launched institutional website that is receiving accolades from all over ... chapter in the fascinating story of Drug Discovery   , ... on the world of clinical research, ranging from information for ...
(Date:12/17/2014)... N.J. , Dec. 17, 2014  IGI Laboratories, ... today the closing of its offering of $125 million ... 2019 (the "Notes").  The Notes were offered and sold ... under the Securities Act of 1933, as amended (the ... a fixed rate of 3.75% per year, payable semiannually ...
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 17, ... (CTMC), and Integrated Clinical Trial Services, LLC (ICTS), ... for clinical trials announce that they have formed ... Services (i-CTMS). i-CTMS will provide a broad range ... biotechnology and medical device companies. i-CTMS ...
Breaking Medicine Technology:Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 2Dompé Offers a New "Window" on the World of Scientific Research, with the http://www.dompetrials.com Website, Dedicated to Clinical Trials 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 2IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 3IGI Laboratories Announces Closing of $125 Million of 3.75% Convertible Senior Notes Due 2019 4Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3
... Oct. 10, 2011 Complementary and alternative medical (CAM) ... in the United States, especially among older patients and ... can have serious and potentially harmful side effects when ... to a review article in the Journal of ...
... 10, 2011 Groupe Athena, Inc. (Pink sheets GATA.PK) announced ... September 30, 2011 which generated pretax earnings of $1,566,906, or ... same period. With the most recent strong quarter, trailing twelve ... record quarterly revenue was significant in that it equaled nearly ...
Cached Medicine Technology:Herbal Supplements May Cause Dangerous Drug Interactions in Orthopaedic Surgery Patients 2Herbal Supplements May Cause Dangerous Drug Interactions in Orthopaedic Surgery Patients 3Herbal Supplements May Cause Dangerous Drug Interactions in Orthopaedic Surgery Patients 4Groupe Athena, Inc. Reports Record First Quarter Revenues 2Groupe Athena, Inc. Reports Record First Quarter Revenues 3
4.625 inches, curved blade 4 mm....
Alvis foreign body spud 4 3/4 inches, oval curette 1 x 3 mm with fine point....
DIX foreign body spud 4 3/4 inches, 1.7 x 15 mm blade....
In reversible handle for removing foreign bodies....
Medicine Products: