Navigation Links
University of Maryland researchers identify fish protein that may inhibit cancer metastasis
Date:3/19/2013

BALTIMORE March 19, 2013. Researchers at the University of Maryland School of Medicine have identified a peptide, or protein, derived from Pacific cod that may inhibit prostate cancer and possibly other cancers from spreading, according to preclinical research published online in the Proceedings of the National Academy of Sciences (PNAS).

"The use of natural dietary products with anti-tumor activity is an important and emerging field of research," says senior author Hafiz Ahmed, Ph.D., assistant professor of biochemistry and molecular biology at the University of Maryland School of Medicine and scientist at the Institute for Marine and Environmental Technology (IMET). "Understanding how these products work could allow us to develop foods that also act as cancer therapeutics and agents for immunotherapy."

Most people who succumb to cancer die because tumor cells invade the surrounding tissue and migrate into the nearby blood and lymph vessels, a process known as metastasis. For example, prostate cancer typically spreads to the bones, lungs and liver. Cancer cells that metastasize to other parts of the body grow new blood supplies and eventually overcome the person's organ systems.

"This study is among the first to explore the therapeutic utility of a bioactive cod TFD-containing glycopeptide to inhibit prostate cancer from progressing," says Dr. Ahmed, who also is affiliated with the University of Maryland Marlene and Stewart Greenebaum Cancer Center. The TFD (Thomsen-Friedenreich disaccharide) antigen in the fish protein is hidden in normal human cells but is exposed on the surface of cancer cells and is believed to play a key role in how cancer spreads.

Polar fish, such as northern cod, express glycoproteins that are rich in the TFD antigen, which protect them from freezing. The research team developed a special form of TFD, called TFD100, purified from Pacific cod.

Using animal models, the researchers found that TFD100 binds to galectin-3, a protein that is overexpressed in prostate cancer cells, and blocks its interaction with the TFD antigen found on the surface of the cells. Galectin-3 (gal3) enables cancer cells to adhere to the walls of blood vessels and also kills activated T-cells, a type of white blood cell, which helps the cancer cells to spread throughout the body and evade the immune system. The researchers observed that TFD100 prevents cancer cells from attaching to the vessel walls, suppresses T-cell death and boosts the immune response.

"Because the gal3-TFD interaction is a key factor driving metastasis in most epithelial cancers, this high-affinity TFD100 should be a promising anti-metastatic agent for the treatment of various cancers, including prostate adenocarcinoma," the researchers conclude in the study, which was published online March 11 in PNAS' Early Edition.

"This research breaks new ground in our ongoing quest to discover new ways to prevent cancers from metastasizing to distant parts of the body," says E. Albert Reece, M.D., Ph.D., M.B.A., Vice President for Medical Affairs at the University of Maryland and the John Z. and Akiko K. Bowers Distinguished Professor and dean of the University of Maryland School of Medicine. "If we could one day offer patients a natural dietary supplement, derived from fish proteins, which could help to block that process, we could have a significant impact on improving patients' outcomes and survival."

Co-investigator Dhan V. Kalvakolanu, Ph.D., a professor of microbiology and immunology at the School of Medicine, notes that additional research is needed to develop a dietary supplement from the cod peptide that could complement chemotherapy and other standard treatments. "No single drug on its own is going to offer protection against advanced cancers. We need a multi-pronged approach to successfully treat this disease," he adds.

The study was conducted by researchers from Dr. Ahmed's laboratory, in collaboration with Dr. Kalvakolanu and other investigators at the University of Maryland Greenebaum Cancer Center and the IMET. Prasun Guha, Ph.D., a postdoctoral fellow in Dr. Ahmed's laboratory, was the study's lead author.


'/>"/>

Contact: Karen Warmkessel
kwarmkessel@umm.edu
410-328-8919
University of Maryland Medical Center
Source:Eurekalert

Related medicine news :

1. Loyola University New Orleans Presents a History of Nursing in its New Infographic: Nursing Evolution
2. Wexford University Spring Classes for Online Doctoral Degree in Applied Sport Psychology Begin April 1
3. University of Houston psychology professor honored with Lifetime Distinguished Career Award
4. American University researcher awarded $2.4 million NIH grant
5. Spring Quarter Classes for Wexford University Bachelor’s Degree in Health and Fitness Classes Begin April 1
6. Launch of Chinese-German Center for Bio-Inspired Materials at Mainz University Medical Center
7. Concordia University, Nebraska Faculty Member Headed to Guatemala for Mission Trip
8. Body Beast: Review Examining Beachbody’s Muscle-Building Workout Program Released By GentlemensUniversity.com
9. Sun Yat-sen University and Johns Hopkins sign collaboration agreement
10. Members of University Services Sleep Diagnostic & Treatment Centers Wake Up Industries and Communities to the Importance of Sleep for Sleep Awareness Week
11. Book by University of Oregon psychologists opens eyes on betrayal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... ST. PAUL, Minn. (PRWEB) , ... May 22, 2017 , ... ... one young man’s experience learning to live with Bipolar 1. Donald Rodriguez takes readers ... icy mountain in Alaska in the dead of winter and to a dark place ...
(Date:5/21/2017)... , ... May 19, 2017 , ... Chris Cornell, 52, was found dead on the ... one of the most respected lead singers in the rock industry would take his own ... mental illness. FindaTopDoc investigates how mental illness played a role in the death of ...
(Date:5/21/2017)... ... May 21, 2017 , ... ... together a cross-disciplinary group of scholars, policymakers, and activists wanting to address equity ... Equity is the third book from a recent series of from this ...
(Date:5/19/2017)... Delaware (PRWEB) , ... May 19, 2017 , ... In ... home, PlushBeds , a luxury online mattress company that specializes in natural and ... (the nation’s leading grassroots autism organization) for every unique share their recent viral ...
(Date:5/19/2017)... ... May 19, 2017 , ... The Hill Agencies, a family managed ... throughout the California Central Valley, is announcing a joint charity initiative with the Boys ... a local kid’s camp event. , The Boys and Girls Club of Kern County ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... 10, 2017 Hologic, Inc. (Nasdaq: ... the fiscal second quarter ended April 1, 2017 . ... increased 666.7% compared to the prior year period as ... a significant gain, while non-GAAP diluted EPS of $0.50 ... 3.8% in constant currency terms.  Excluding the effects of ...
(Date:5/9/2017)... May 9, 2017 Zimmer Biomet Holdings, Inc. ... healthcare, today announced it has earned a spot on ... list. The Company was ranked among 500 U.S. employers ... and Healthcare Equipment and Services. The annual ... an anonymous, independent survey of over 30,000 employees across ...
(Date:5/8/2017)... , May 8, 2017  Diplomat Pharmacy, Inc. ... Communications, Inc. ("WRB"), a health care service center ... WRB specializes in relationship management programs for ... WRB will join ... commercialization support services for manufacturers, biotech firms, and other ...
Breaking Medicine Technology: