Navigation Links
University of Maryland researchers discover possible drug targets for common non-Hodgkin's lymphoma
Date:7/19/2011

cancer cells lose this ability and consequently grow uncontrollably.

E. Albert Reece, M.D., Ph.D., M.B.A., vice president of medical affairs at the University of Maryland and dean of the University of Maryland School of Medicine, says, "This is a very important discovery that may ultimately benefit patients with diffuse large B-cell lymphoma, a common hematological malignancy that can be difficult to treat. These findings provide valuable new insight into the molecular make-up of this cancer that may lead to new targeted drug therapies."

Lymphoma is a cancer that originates in the lymphocytes (a type of white blood cell) of the immune system. Diffuse large B-cell lymphoma is a fast-growing, aggressive form of non-Hodgkin's lymphoma. It accounts for about 30 to 35 percent of all non-Hodgkin's lymphomas, and about 25,000 new cases are diagnosed each year. Non-Hodgkin's lymphomas usually are treated with several types of chemotherapy cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) and a biological therapy, such as the monoclonal antibody rituximab (Rituxan). Radiation therapy may be used on occasion, and bone marrow or stem cell transplantation may also be a treatment option.

Dr. Gartenhaus says researchers hope the study findings will help to develop new therapies that will be effective and well-tolerated by patients. "We believe it is important to identify drugs that can improve the efficacy and reduce the toxicity of standard anti-lymphoma therapy," he says.

The new research showed that using compounds to inhibit ERK and CHK2 did not cause any significant damage to normal cells or tissue examined in the lab, according to Bojie Dai, Ph.D., a postdoctoral fellow at the University of Maryland School of Medicine and the lead author. "We hope that new therapies directed at these two proteins would have modest side effects because they would target only the lymphoma cells," Dr. Dai says.

Dr. Gartenhaus say
'/>"/>

Contact: Karen E. Warmkessel
kwarmkessel@umm.edu
410-328-8919
University of Maryland Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Columbia University Medical Center receives $38.9 million to help translate science into treatment
2. Wayne State University engineering student receives American Tinnitus Association award
3. Mainz University Medical Center deploys new system for therapy of metastatic spinal tumors
4. Wayne State University researcher argues that sex reduces genetic variation
5. New book by Indiana University physicians slays health myths we all thought were true
6. Health providers should emphasize breast cancer screening, Wayne State University research finds
7. Researchers at Oregon Health & Science University discover MS-like disease in monkeys
8. Religion benefits traumatic brain injury victims, Wayne State University research finds
9. Internationally recognized BME professor to join University of Texas as visiting scholar
10. Three senior Hebrew University faculty members receive Kaye Awards for innovations
11. Wayne State University researchers win grant from the NSF to target tinnitus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... In a July 9th article in the Money ... Lotus Blossom Consulting LLC , was quoted in a Family ... Cut the High Cost of Infertility . Her advice began ... maximize your chance of success from the first attempt.” The ... “I am always happy to talk with the media ...
(Date:7/24/2014)... its 2014 Power of A Award winners, including two ... , The ASA Global Humanitarian Outreach (GHO) program ... the top honors from ASAE. GHO was honored for ... on the global anesthesia crisis and supporting low income ... honored with a Power of A Silver Award for ...
(Date:7/24/2014)... Kathleen Doheny HealthDay Reporter ... children often don,t view their kids as unhealthy or recognize ... a new study. The children of the families surveyed ... the Hasbro Children,s Hospital in Providence, R.I. "A third ... study researcher Dr. Kyung Rhee, now an assistant professor of ...
(Date:7/24/2014)... Pools and beaches are the place to be ... especially for small children, so Amica Insurance is ... the Centers for Disease Control and Prevention, children between the ... water-related injuries and deaths. It’s important to know the best ... is offering the following tips from the American Red Cross:, ...
(Date:7/24/2014)... treatment of overweight and obese preschoolers works better when ... only the child is targeted, according to research published ... the University at Buffalo and Women and Children,s Hospital ... or obese and had one parent who participated in ... to body mass index (BMI) measurements, calculated based on ...
Breaking Medicine News(10 mins):Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 2Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 3Health News:Parents of Obese Kids Often View Them as Healthy 2Health News:Parents of Obese Kids Often View Them as Healthy 3Health News:Keep Kids Safe in the Water with 5 Tips from Amica 2Health News:Overweight and obese preschoolers lose more weight when parent is also treated 2Health News:Overweight and obese preschoolers lose more weight when parent is also treated 3
... Formulary, the leading provider of access to and ... to customized formulary data and co-pay reports. Fingertip ... now offers subscribers the ability to save report ... offers eleven comprehensive reports that provide real-time current ...
... opens new office outside of Seattle, expands workforceTAMPA, ... Targeted Population Health Management company focused on the ... expanding its workforce to include more than 40 ... Lynnwood, Wash. The new site is the Company,s ...
... Full Year Highlights:- Fourth quarter net service revenues increased ... increased 61% to $212.6 million- Fourth quarter Visiting Nurse ... full year VN net revenues rose 80% to $173.0 ... million; full year net income increased 114% to $16.3 ...
... Demonstrates Ability to Treat Subcutaneous InfectionsEMERYVILLE, Calif., March ... a clinical stage biopharmaceutical company, today announced that ... molecule in NovaBay,s, proprietary Aganocide(R) class of compounds, ... Dermatology (AAD) 67th Annual Meeting in San Francisco ...
... LOUIS, Missouri, March 4 Elsevier,world-leading publisher of ... pleased to announce the July 2009 launch of ... American College of,Osteopathic Family Physicians (ACOFP), Osteopathic Family ... Physician, Official Journal of the American College of,Osteopathic ...
... help him find the surgeon in India his U.S. cardiologist recommended. Just ... overseas completed. He,s now home and enjoying his new lease on life. ... ... his chronic fatigue was due to a problem with his heart,s mitral valve, ...
Cached Medicine News:Health News:Fingertip Formulary Analytics(R) Offers One-Click Access to Customized Formulary Data and Co-Pay Reports 2Health News:Health Integrated Enjoys Steady Growth 2Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 2Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 3Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 4Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 5Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 6Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 7Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 8Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 9Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 10Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 11Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 12Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 13Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 14Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 15Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 16Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 17Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 18Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 19Health News:Almost Family Reports Fourth Quarter and Full Year 2008 Results 20Health News:NovaBay Pharmaceuticals Announces New Preclinical Data to be Presented at the American Academy of Dermatology (AAD) 67th Annual Meeting 2Health News:NovaBay Pharmaceuticals Announces New Preclinical Data to be Presented at the American Academy of Dermatology (AAD) 67th Annual Meeting 3Health News:Elsevier Announces Launch of Osteopathic Family Physician Publishing Partnership Formed With American College of Osteopathic Family Physicians 2Health News:Elsevier Announces Launch of Osteopathic Family Physician Publishing Partnership Formed With American College of Osteopathic Family Physicians 3Health News:Ohio Patient Thanks India and WorldMed Assist For Heart Surgery Overseas; His Indian Surgeon Thanks U.S. for Superb Training 2Health News:Ohio Patient Thanks India and WorldMed Assist For Heart Surgery Overseas; His Indian Surgeon Thanks U.S. for Superb Training 3
(Date:7/24/2014)... , July 24, 2014 LSI Medience ... an Agreement with Kineticos, a Raleigh-Durham, ... Kineticos will support LSI Medience in identifying opportunities ... to demonstrate utility in clinical trials. ... utility in diagnosis of sepsis, prognosis of septic ...
(Date:7/24/2014)... , July 24, 2014  Lazarus Effect, ... of novel interventional devices to facilitate removal of ... Patent and Trademark Office has issued a new ... behind the company,s Lazarus Cover TM and ... Lazarus ReCover is a single-component stent-retriever (stentriever) with ...
(Date:7/24/2014)... July 24, 2014 /PRNewswire-iReach/ -- "North America Orthopedic Braces ... data on the North America Orthopedic Braces and Supports ... dollars, and volume (in units) and average price data ... Knee Braces and Supports , Ankle Braces and ... Upper Extremities Braces and Supports. ...
Breaking Medicine Technology:LSI Medience Corporation and Kineticos Sign Agreement Related to the Presepsin Biomarker in Sepsis Management and Treatment 2Lazarus Effect Receives Notice of Allowance for New US Patent Covering Core Protection Technology 2North America Orthopedic Braces and Supports Market (Knee, Ankle & Spinal Braces) to 2020 2North America Orthopedic Braces and Supports Market (Knee, Ankle & Spinal Braces) to 2020 3North America Orthopedic Braces and Supports Market (Knee, Ankle & Spinal Braces) to 2020 4North America Orthopedic Braces and Supports Market (Knee, Ankle & Spinal Braces) to 2020 5
... , POTOMAC FALLS, Va., Nov. 9 TessArae® ... announces the launch of new integrated product solutions ... human hereditary diseases. The combination of TessArae,s ... basecalling algorithms and analysis software enables screening for ...
... /PRNewswire/ -- On Sept. 11, 2001, thousands of ... save as many lives as possible in New York City. ... responders. Now he is fighting to save his own life. ... cancer in 2006. He has undergone surgery and extensive chemotherapy ...
Cached Medicine Technology:TessArae Delivers Lower Cost Option to Genetic Testing Market 2The SCOOTER Store Surprises 9/11 First Responder & Merrick Firefighter With Power Chair 2The SCOOTER Store Surprises 9/11 First Responder & Merrick Firefighter With Power Chair 3
... Basic ergonomic chairs with concave seats ... • Select options like seats, backrests, ... BTC/1Q chairs are recommended for the ... room, static control, health care and ...
... concave seats and standard-sized backrests with ... seats, backrests, armrests, and casters and ... for the following environments: industry, education, ... care and office. • With cast ...
... ergonomic chairs with concave seats and ... Select options like seats, backrests, armrests, ... chairs are recommended for the following ... static control, health care and office. ...
... chairs with concave seats and standard-sized ... options like seats, backrests, armrests, and ... are recommended for the following environments: ... control, health care and office. • ...
Medicine Products: