Navigation Links
University of Leicester cancer researchers investigate 'smoking gun' trail
Date:10/10/2007

The University of Leicester has been selected as the hub of a worldwide network of researchers to investigate one of the causes of cancer.

The study into the smoking gun trail of devastation caused to the body by substances known as free radicals will also impact on our understanding of heart disease, neurodegenerative disease and arthritis.

Dr Marcus Cooke, Senior lecturer in the Radiation and Oxidative Stress Section at the University of Leicester, said: Most of us have heard of free radicals, and the benefits of antioxidants which mop them up - even if it is just from cosmetics commercials.

However, premature aging is just the tip of the iceberg for their detrimental effects. Free radicals have been implicated in many diseases. They are arguably the most prevalent cancer causing chemicals known.

Free radicals are highly reactive, and can cause widespread damage to cells, and in particular DNA - the cell's blueprint. Whilst it is very difficult to measure free radicals themselves, we can measure this damage as a 'smoking gun' signature of free radical activity.

Being able to accurately and sensitively measure this damage will allow us to:

  • get a better understanding of the role of this damage in disease

  • develop assays to determine disease risk, by measuring cell damage
  • design strategies to prevent, or encourage repair, of this damage, and hence prevent disease

This research is particularly important because it provides validated, non-invasive methods for assessing oxidative stress in humans. Being non-invasive this is ideal for looking in young and old patients.

It will allow us to develop reference ranges to identify what levels of damage in urine are normal, or abnormal, for clinical application and to develop disease risk/prognostic tests.

Dr. Cooke has been made PI of a project (Euros 45k) to undertake the Europe-wide validation of a urinary biomarker of oxidative stress.

This is one of two studies where Leicester is playing a lead role. Dr. Mark D. Evans is the Principal Investigator in a Euros 60k study to better understand the sources of biomarkers of oxidative stress in urine.

Both projects are spin-offs from a larger Euros 11 million EU Network of Excellence grant (Environment, Cancer, Nutrition and Individual Susceptibility, ECNIS, www.ecnis.org) of which Professor Peter Farmer, of the Department of Cancer Studies and Molecular Medicine, is the project lead at Leicester. (see link at end of release)

Dr Evans said: These are projects addressing fundamental questions that have been, for the most part, overlooked. Being awarded these two complimentary projects, back-to-back gives us the unique opportunity to address questions that we, and others in the scientific community, have wanted to examine for many years. Likewise, this project incorporates worldwide collaborations between Leicester, Collegium Medicum in Bydgoszcz, Poland; DKFZ (the German Cancer Institute), Heidelberg, Germany; Institute of Cancer Research Sutton, U.K; Medical Institute of Bioregulation, Fukuoka, Japan; and Department of Toxicogenetics, University of Leiden, The Netherlands.

Dr Cooke said: This is a further reflection of the international status of our group within the free radical and biomonitoring community. Through these projects, we are working closely with many of the top research institutes worldwide.

Dr Cooke said Leicester would act as the hub of a worldwide network of more than 17 laboratories comparing methods of measuring damage to DNA, in urine: Once we have agreement between methods, we can apply these methods to the study of DNA damage in disease.


'/>"/>

Contact: Dr. Marcus S. Cooke
msc5@le.ac.uk
University of Leicester
Source:Eurekalert

Related medicine news :

1. Researchers at Cornell University as been reported using research fund by false claims
2. A new study by John Hopkins University proposes formula for good health
3. James Cook University urges more medical seats
4. Pill splitting program of University of Michigan can save money
5. Distinguished Scientist Award Conferred on University of Rochester Scientists for Work on Preventing Cavities
6. Yale University guidelines for Physicians and Pharmaceutical industry
7. $ 1.7 Million NYSTAR Award for Binghamton University to Flex Electronics Research Muscle.
8. Florida State University declares a breathtaking study which might solve the Hepatitis C Virus maze and find a cure!
9. Hwang Woo Suk Suspended By Seoul National University
10. Vladeck to head the University of Medicine and Dentistry of New Jersey
11. Rice University wins Prestigious Grants from HHMI
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
(Date:6/23/2016)... -- In a startling report released today, National Safety Council ... comprehensive, proven plan to eliminate prescription opioid overdoses. Prescription ... are tackling the worst drug crisis in recorded U.S. history, assigned ... Kentucky , New Mexico , ... 28 failing states, three – Michigan , ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
Breaking Medicine Technology: