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University of Kentucky spinoff licensed to develop Alzheimer's treatment
Date:9/22/2011

LEXINGTON, Ky. (Sept. 21, 2011) -- CoPlex Therapeutics has signed an exclusive global license agreement with Hawthorn Pharmaceuticals to develop and commercialize hawAD14, a preclinical oral small molecule candidate for the treatment of Alzheimer's and other neurodegenerative diseases.

According to a released statement from Hawthorn Pharmaceuticals, a commercial-stage specialty drug company, research indicates hawAD14 significantly decreases production of amyloid beta (Aβ) the major component of senile plaques and alters proteins associated with hyperphosphorylation of tau which is associated with neurofibrillary tangles present in Alzheimer's disease.

"In terms of the discovery's uniqueness, it's one of only a few programs in the world demonstrating multiple protective effects against the predominant pathogenic pathways of Alzhiemer's disease," said Rob Lewis, chief scientific officer at Hawthorn. "We are in the process of completing necessary preclinical studies in order to file an IND (investigational new drug) with the FDA," said Hawthorn CEO Max Draughn.

CoPlex co-founder and CEO John Beran said, "University of Kentucky researchers and CoPlex founding scientists Mark Lovell and Bert Lynn discovered an aberrant protein complex linked to Alzheimer's which gave them a unique approach to begin to interrupt pathogenic mechanisms associated with the disease. They evaluated multiple compounds to see if they could minimize events on the path toward Alzheimer's and the leading candidate was hawAD14."

"The discovery of hawAD14 may be the most promising research of our professional careers," said Mark Lovell, Jack & Linda Gill Professor of Chemistry and research faculty with the UK Sanders-Brown Center on Aging. "We are extremely excited by the potential this compound holds to slow the progression of Alzhiemer's and significantly improve the lives of individuals impacted by this terrible disease." Lovell worked as a graduate
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Contact: Allison Elliott
allison.elliott@uky.edu
University of Kentucky
Source:Eurekalert  

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University of Kentucky spinoff licensed to develop Alzheimer's treatment
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