Navigation Links
University of Hawaii cancer researchers discover gene defect responsible for cancer syndrome
Date:9/6/2012

HONOLULU, HI - University of Hawai'i Cancer Center researchers have discovered germline BAP1 mutations are associated with a novel cancer syndrome characterized by malignant mesothelioma, uveal melanoma, cutaneous melanoma and atypical melanocytic tumors. Germline mutations are hereditary gene defects that are present in every cell.

The study investigated two unrelated families with BAP1 defects and found an increase in the occurrence of mole-like melanocytic tumors that are non-cancerous flat or slightly elevated and pigmented skin lesions. These benign skin lesions were found to carry the BAP1 mutation and it was concluded that people with this specific type of melanocytic lesion are at higher risk of developing melanoma and mesothelioma.

This discovery provides physicians with a visual marker in identifying individuals that may carry germline BAP1 mutations. People having this syndrome should reduce their exposure to environmental risk factors such as UV radiation for melanoma and avoid erionite and asbestos exposure for mesothelioma. It will also help identify individuals who are at higher risk for melanomas which is usually cured with timely detection and to assist in the early detection of mesothelioma which typically leads to better prognosis.

"Identifying this gene as a cause of several cancers can tell us who is at risk in a family before the cancer develops," said Michele Carbone, MD, PhD, director of the UH Cancer Center and professor of pathology, John A. Burns School of Medicine. "We can advise patients to undergo routine exams and genetic testing for early diagnoses and treatment." Carbone is the leading author of the paper included in the August 30, 2012 issue of the Journal of Translational Medicine, published by BioMed Central.

This novel gene-testing has been patented by Carbone and colleagues and is performed exclusively at The Queen's Medical Center in Honolulu, Hawaii where they receive genetic samples from across the entire United States. Carbone previously discovered that individuals who carry BAP1 mutations are susceptible to developing mesothelioma and melanoma of the eye. This latest discovery builds on this and other research on the BAP1 mutation.


'/>"/>
Contact: Lori Strelow
lstrelow@cc.hawaii.edu
808-356-5753
University of Hawaii Cancer Center
Source:Eurekalert

Related medicine news :

1. Oxford University Press acquires American Journal of Hypertension
2. Queens University Belfast wins national environment award
3. Non-invasive treatment for children with obstructive sleep apnea suggested by Ben-Gurion University study
4. University of Colorado Cancer Center earns major grant to develop new bladder cancer drugs
5. Hospital of the University of Pennsylvania selected to lead US nurse-training initiative
6. University of Pennsylvania and Novartis form alliance to expand use of personalized T cell cancer therapy
7. Boston University researchers expand synthetic biologys toolkit
8. Canadians super-sizing Canadas Food Guide servings: York University study
9. Tel Aviv University researcher says plants can see, smell, feel, and taste
10. Tel Aviv University research links childhood obesity to cancer risk
11. Marshall University scientist awarded NIH grant for lung cancer research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... Marietta, GA (PRWEB) , ... April 25, 2017 ... ... implant and instrument solutions, announces the continuation of its strategic partnership with and ... surgeons in developing nations in the safe and effective management of complex spine ...
(Date:4/24/2017)... WASHINGTON, DC (PRWEB) , ... April 24, 2017 , ... ... was recognized during ATA 2017: Telehealth 2.0 — the American Telemedicine Association’s annual conference, ... the Santana Telehealth Project for using telemedicine to improve the lives of the poor ...
(Date:4/24/2017)... Antonio, TX (PRWEB) , ... April 24, 2017 , ... ... by the glitterati, those unreal icons inhabiting the rarified air of pop and film ... the paparazzi and anyone snapping pictures: the smile. Grins now run the gamut from ...
(Date:4/24/2017)... ... 24, 2017 , ... Veteran Theresa James awoke to the sound of her ... In “Healing Tears,” James depicts every parent’s worst nightmare, when her three children were ... conversations and situations throughout my divorce,” James said. “After the death of my children, ...
(Date:4/24/2017)... ... April 24, 2017 , ... My T Chai, a South African company ... available for purchase on RevNutrition.com, a popular website specializing in sales of nutritional products. ... in ancient India and Siam. It spread across Asia and Africa quickly, and today ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... , April 18, 2017  Cardinal Health (NYSE: ... 1 fiscal 2017 earnings per share (EPS) guidance ... 2019.  This is in conjunction with this morning,s announcement ... Vein Thrombosis and Nutritional Insufficiency businesses. Cardinal ... continuing operations will be at the bottom of its ...
(Date:4/18/2017)... , April 18, 2017 Research and Markets ... 2017-2021" report to their offering. ... The global arthroscopy devices market to grow at a CAGR ... Global Arthroscopy Devices Market 2017-2021, has been prepared based on an ... the market landscape and its growth prospects over the coming years. ...
(Date:4/18/2017)... SUNNYVALE, Calif. , April 18, 2017 /PRNewswire/ ... results of collaboration started in 2016, in which ... "Artificial Brain SOINN". The companies achieved initial results ... ultrasound solution by Artificial Brain SOINN. The results ... Tokyo Big Sight, April 19-21, at booths 4505 ...
Breaking Medicine Technology: