Navigation Links
University of Hawaii at Manoa CRCH scientists report adulthood body size associated with cancer risk
Date:9/11/2009

A team of scientists led by researcher Brenda Hernandez, Ph.D., M.P.H.an assistant professor at the University of Hawai'i at Mānoa's Cancer Research Center of Hawai'ihas reported that body mass in younger and older adulthood, and weight gain between these life periods, may influence a man's risk for prostate cancer. This risk varies among different ethnic groups, according to findings reported in a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Dr. Hernandez and colleagues studied the relationship in a multiethnic population consisting of blacks, Japanese, Hispanics, Native Hawaiians and whites, and compared differences among age groups using the Multiethnic Cohort, a longitudinal study of men 45-75 years of age established in Hawai'i and California from 1993-1996. Of the 83,879 men who participated in the study, 5,554 developed prostate cancer. Overall, men who were overweight or obese by age 21 had a decreased risk of localized and low-grade prostate cancer, according to Dr. Hernandez.

Their results suggested that being overweight in older adulthood was associated with increased prostate cancer risk among white and Native Hawaiian men, but a decreased risk among Japanese men. While excessive weight gain between younger and older adulthood was observed to increase the risk of advanced and high-grade prostate cancers in white men and increase the risk of localized and low-grade disease in black men, it appeared to decrease the risk of localized prostate cancer in Japanese men.

Dr. Hernandez said, "The relationship of certain characteristics, such as body size, with cancer risk may vary across ethnic groups due to the combined influence of both genes and lifestyle."

Obesity is a known risk factor in other common cancers, including colorectal cancer and breast cancer in post-menopausal women. However, the relationship between body size and prostate cancer risk is not entirely understood.

Excess fat is associated with a number of conditions that contribute to cancer development including low-grade chronic inflammation, insulin resistance, metabolic abnormalities, and hormone imbalances. These conditions may in turn contribute to more aggressive prostate malignancies.

Ethnic differences in cancer risk may be explained by differences in the distribution of stored body fat that could have a differential effect on the development of prostate cancer. For example, in comparison to whites, Asian men and women tend to accumulate more fat in their upper bodies and less fat in their lower bodies (including legs and buttocks). These differences in the distribution of body fat may influence the specific way that excess fat influences cancer risk.

Elizabeth A. Platz, Sc.D., M.P.H., associated professor of epidemiology at the Johns Hopkins Bloomberg School of Public Health, Baltimore, and an editorial board member for Cancer Epidemiology, Biomarkers & Prevention, emphasized as a strength of this study, in spite of its inconsistency across racial/ethnic groups, that it was conducted prospectively and consisted of large numbers of men in most of the ethnic groups studied. An estimated 30 percent of prostate cancer cases occurred among Japanese men, 25 percent among white men, 27 percent among Hispanic men, 13 percent among black men, and seven percent among Native Hawaiian men. According to Dr. Hernandez, their findings do not warrant a change in public health messages about obesity that all men of normal weight should be encouraged to avoid weight gain and those who are overweight or obese should be encouraged to lose weight to achieve good health.


'/>"/>

Contact: Sharon Shigemasa
sharon@crch.hawaii.edu
808-586-3011
University of Hawaii at Manoa
Source:Eurekalert

Related medicine news :

1. University of Iowa professor identifies new eating disorder
2. University of Wisconsin Hospitals and Clinics Complete System-Wide Conversion to Masimo SET Pulse Oximetry Technology
3. University of Texas Study Details Lengthy Payment Delays for Medicare Part D Prescription Drug Claims, Confirming Need for Legislative Fix
4. Tulane University to receive $14M for international HIV/AIDS program
5. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
6. Boston University School of Medicine researcher recipient of Memory Ride Grant
7. Loma Linda University Medical Center Selects Beryl to Manage Call Center Interactions for Womens Services Programs and Departments
8. Medina General Hospital and University Hospitals Agree to Pursue Affiliation
9. J.D. Power and Associates Reports: Hackensack University Medical Center Recognized as First Hospital to Achieve Distinction for Providing an Outstanding Inpatient Experience in All Four Service Areas
10. The First Incisionless Transoral Fundoplication for Treatment of Gastroesophageal Reflux is Performed in the U.S. at Ohio State University and Oregon Health & Science University Medical Centers
11. George Mason University professor receives $2.6 million NIH grant to study Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: