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University of Granada researchers identify changes in tumor cells that lead to metastasis
Date:1/17/2012

sity of Granada professor Jos Antonio Lorente -GENYO manager director and coordinator of the research group- affirms that the study of Circulating Tumor Cells (CTCs) is crucial "not only because they may be responsible for the development of metastasis, but also because they have genetic characteristics different to those found in the primary tumor and in metastatic cells. Such characteristics make these very aggressive cells resistant to the immunologic system and to the therapeutic agents generally used in cancer patients". Most of these treatments are targeted against proliferating tumor cells. Conversely, CTCs are found in a "dormant" phase, i.e. in a "non-proliferation" phase.

As these cells may indicate negative response to treatment, if they were isolated and genetically characterized, patients could be classified according to their chances of relapse, which would allow individualized follow-up.


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Contact: Dr. Jos Antonio Lorente Acosta. GENYO manager director
jlorente@ugr.es
34-958-637-079
University of Granada
Source:Eurekalert

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