Navigation Links
University of East Anglia makes cancer breakthrough

Scientists at the University of East Anglia have made an important breakthrough in the way anti-cancer drugs are tested.

A tumour cannot grow to a large size or spread until it has developed its own blood supply and leading research has looked for a way of halting capillary formation to stop tumours taking hold.

But new findings published today in the Journal of Cell Science have shown that scientists testing such treatments may not have been studying exactly what they thought they were.

The research proves that cells are able to switch their genetic profile turning off genes expressed by blood vessel cells and turning on genes specific to lymphatic cells.

This "switch" was previously thought to be impossible and means that scientists may have been researching lymphatic cells, rather than blood vessel cells. It is hoped the discovery will propel the race to find revolutionary new treatments.

Lead author Dr Lin Cooley, said: "It has always been thought that cells could not change from blood to lymphatic vascular cells.

"Other researchers have been doing experiments thinking they were looking at blood vessel cells, when in fact they were looking at lymphatic vascular cells. This breakthrough is important because they have not been studying what they think they have been studying.

"It is a big discovery and will be very important in testing potential anti-cancer drugs."

Researchers used human vein cells in experiments where they form capillaries - the smallest of the body's blood vessels - when cultured in various environments similar to the body.

The human vascular system is made up of two separate circulatory networks the blood and lymphatic vasculature. Blood vessels and lymphatic vessels are structurally similar, but have very different roles, and are made up of two distinct cell types.

Dr Cooley said: "We have discovered that when vein cells form tube structures, they appear to "switch" their genetic profile, turning off genes expressed by blood vessel cells, and turning on genes specific to lymphatic vessels.

"This change can be reversed, and is dependent on the particular environment they are cultured in.

"We have also shown that their identity changes in response to the cell's environment rather than only being specified by signals during early embryonic development".


Contact: Lisa Horton
University of East Anglia

Related medicine news :

1. University of Miami receives grant to increase the number of family nurse practitioners
2. University of Colorado gets federal award for Cord Blood Bank
3. UC San Diego partners with Mozambique University to deliver quality health care
4. Better cholesterol drugs may follow Saint Louis University researchers breakthrough
5. U-M Medical School creates joint institute with Peking University
6. University Hospitals Case Medical Centers neuroscience intensive care unit earns Beacon Award
7. Researchers at the University of Granada associate trigger points with shoulder injury
8. The University of Warsaw obtains 3-year site license to Science to provide site-wide access to research institutions in Poland
9. McGill to host inter-university Family Medicine Student Symposium
10. University Hospitals Case Medical Center implements AutoLITT system for treatment of brain tumors
11. Queens University researchers locate impulse control center in brain
Post Your Comments:
Related Image:
University of East Anglia makes cancer breakthrough
(Date:11/30/2015)... ... , ... While powdered supplements and drinks can reduce food preparation time, locating ... Va., has found an easy to keep track of the scoop. , He developed ... in a canister or other container handy and readily accessible. As such, it prevents ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... just publishing magazines and websites specializing in independent living, assisted living and all ... paramount, and Alzheimer’s awareness and research remains a top priority. ...
(Date:11/30/2015)... Morton Grove, IL (PRWEB) , ... November 30, 2015 , ... ... milestone for an emerging pharmaceutical company. Because it is so important to this key ... titled “Success Factors in your IND Filing” on December 4th at 11am EST. , ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... of critical importance to the medical schools of the future. To reach an ... suite at the 2015 ChangeMedEd conference in Chicago, organized by the American Medical ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... are pleased to announce their strategic partnership at the Radiological Society of ... Service, Inc., and Winscribe, global providers of cutting-edge dictation and speech-enabled documentation ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015  Precision Image ... services, is pleased to announce a dramatic expansion ... imaging services. Building on its ISO-9001:2008 certification for ... implemented comprehensive Core Lab protocols and procedures. This ... of research activities.  Their Core Lab services include ...
(Date:11/30/2015)... Sectra (STO: SECT B) ... into a multi-year agreement to provide Breast Imaging PACS ... Breast Care to increase collaboration with sub-specialists around the ... --> Sectra (STO: SECT B) ... into a multi-year agreement to provide Breast Imaging PACS ...
(Date:11/29/2015)... Nov. 29, 2015 CIVCO Medical Solutions ... at the Radiological Society of North ... Chicago November 29 – December 4, ... to offer customers unrivaled versatility, enhanced user experience ... --> ...
Breaking Medicine Technology: