Navigation Links
University of East Anglia makes cancer breakthrough

Scientists at the University of East Anglia have made an important breakthrough in the way anti-cancer drugs are tested.

A tumour cannot grow to a large size or spread until it has developed its own blood supply and leading research has looked for a way of halting capillary formation to stop tumours taking hold.

But new findings published today in the Journal of Cell Science have shown that scientists testing such treatments may not have been studying exactly what they thought they were.

The research proves that cells are able to switch their genetic profile turning off genes expressed by blood vessel cells and turning on genes specific to lymphatic cells.

This "switch" was previously thought to be impossible and means that scientists may have been researching lymphatic cells, rather than blood vessel cells. It is hoped the discovery will propel the race to find revolutionary new treatments.

Lead author Dr Lin Cooley, said: "It has always been thought that cells could not change from blood to lymphatic vascular cells.

"Other researchers have been doing experiments thinking they were looking at blood vessel cells, when in fact they were looking at lymphatic vascular cells. This breakthrough is important because they have not been studying what they think they have been studying.

"It is a big discovery and will be very important in testing potential anti-cancer drugs."

Researchers used human vein cells in experiments where they form capillaries - the smallest of the body's blood vessels - when cultured in various environments similar to the body.

The human vascular system is made up of two separate circulatory networks the blood and lymphatic vasculature. Blood vessels and lymphatic vessels are structurally similar, but have very different roles, and are made up of two distinct cell types.

Dr Cooley said: "We have discovered that when vein cells form tube structures, they appear to "switch" their genetic profile, turning off genes expressed by blood vessel cells, and turning on genes specific to lymphatic vessels.

"This change can be reversed, and is dependent on the particular environment they are cultured in.

"We have also shown that their identity changes in response to the cell's environment rather than only being specified by signals during early embryonic development".


Contact: Lisa Horton
University of East Anglia

Related medicine news :

1. University of Miami receives grant to increase the number of family nurse practitioners
2. University of Colorado gets federal award for Cord Blood Bank
3. UC San Diego partners with Mozambique University to deliver quality health care
4. Better cholesterol drugs may follow Saint Louis University researchers breakthrough
5. U-M Medical School creates joint institute with Peking University
6. University Hospitals Case Medical Centers neuroscience intensive care unit earns Beacon Award
7. Researchers at the University of Granada associate trigger points with shoulder injury
8. The University of Warsaw obtains 3-year site license to Science to provide site-wide access to research institutions in Poland
9. McGill to host inter-university Family Medicine Student Symposium
10. University Hospitals Case Medical Center implements AutoLITT system for treatment of brain tumors
11. Queens University researchers locate impulse control center in brain
Post Your Comments:
Related Image:
University of East Anglia makes cancer breakthrough
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... District , the only authorized OSHA Training Institute Education Center headquartered in Northern ... protecting their workers from extreme heat at their worksites. Employers with workers ...
(Date:6/27/2016)... ... 2016 , ... "FCPX editors can now reveal their media with growing colorful ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Color brings the ... can now reveal the media of their split screens with growing colorful panels. , ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... announced today its affiliation with Tennessee Counseling Association. This new relationship ... of the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... strategic partnership with Connance, a healthcare industry leader providing predictive analytics to ... technology combine to provide health systems, hospitals and ambulatory surgical centers with ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is ... emergency ambulance transport experience for the millions of people who require these medical ... the taxi industry through the use of technology. Now, SmartEMS has put forth ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical ... the "Company"), which develops, markets and sells medical devices ... , signed a strategic cooperation agreement with Hongyuan ... "Hongyuan Supply Chain") on June 20, 2016, to develop ... the strategic cooperation agreement, Dehaier will leverage Hongyuan Supply ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: