Navigation Links
University of Colorado team identifies new colon cancer marker
Date:3/25/2011

Aurora, Colo. (March 24, 2011)A research team at the University of Colorado Cancer Center has identified an enzyme that could be used to diagnose colon cancer earlier. It is possible that this enzyme also could be a key to stopping the cancer.

Colon cancer is the third most common cancer in Americans, with a one in 20 chance of developing it, according to the American Cancer Society. This enzyme biomarker could help physicians identify more colon cancers and do so at earlier stages when the cancer is more successfully treated.

The research was led by Cancer Center investigator Vasilis Vasiliou, PhD, professor of molecular toxicology at the University of Colorado School of Pharmacy, and published online in Biochemical and Biophysical Research Communications. Vasiliou's laboratory specializes in understanding the role of enzymes called aldehyde dehydrogenases in drug metabolism, metabolic diseases, cancer and normal and cancer stem cells.

Vasiliou's team studied colon cancers from 40 patients and found a form of this enzyme known as ALDH1B1 present in every colon cancer cell in 39 out of the 40 cases. The enzyme, which is normally found only in stem cells, was detected at extraordinarily high levels.

"Other potential colon cancer biomarkers have been identified in the past, but none thus far are present in such a high percent of the cancer cells and virtually none are overexpressed like this one," says Cancer Center investigator David Orlicky, PhD, associate professor of pathology at the CU medical school and a member of the research team.

This finding is particularly timely as it was recommended last week at the Human Genome 2011 annual meeting that a chemical analysis for biomarkers should always accompany genotyping in early detection of colon cancer, says Vasiliou, who attended the meeting in Dubai.

It appears that ALDH1B1 aids the development or growth of these cancer cells because it would not be present in every cell at
'/>"/>

Contact: Lynn Clark
lynn.clark@ucdenver.edu
303-724-3160
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. University of Virginia Health System Medical Laboratories Selects Sunquest's Specimen Collection Solution
2. Akron Institute of Herzing University Launches Its First Bachelors Degree Programs to Prepare Students for Even Greater Success in Business, Health Care and IT
3. Most pandemic plans in Ontario hospitals have not been tested: Queens University study
4. San Diego State University and BIOCOM Institute Receive $4.95 Million Grant: The BRIDGE Project, Linking Education to Employment in San Diegos Life Sciences Industry
5. Smithsonian Institution, Arizona State University announce education and research partnership
6. Untreated poor vision in elderly linked to dementia, University of Michigan study shows
7. Giarmarco, Mullins & Horton, P.C. President Joseph F. Page to Speak at University of Michigan
8. Arizona State Universitys Decision Theater offers balance to an off-kilter world
9. Forest City Announces Joint Venture with Health Care REIT for University Park Life Science Properties
10. Herzing University Online Launches Master and Bachelor of Science Degrees in Nursing
11. Nurtur Acquires ActivHealth and Wellness by Choice; Gains Exclusive Partnership with Duke University Center for Living
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... (PRWEB) April 25, 2015 Parker and Sons ... and cooling, has spiked in Arizona alongside the growing economy. ... additional forty employees for April to help account for the ... forty employees in April is something we are enthusiastic about. ... said Paul Kelly, president at Parker and Sons. , Indeed, ...
(Date:4/25/2015)... 25, 2015 On Friday, April 17, ... Journal’s annual Best Implementation Award. This award is ... best use of RFID technology to improve its manufacturing, ... company that best demonstrates how RFID is delivering real ... RFID Journal Live! 2015 in San Diego, the RFID ...
(Date:4/24/2015)... York, NY (PRWEB) April 24, 2015 ... sober living residence in Westchester County. Just 35 miles ... help transition individuals back into everyday life while recovering ... Thursday, May 7, 2015, will allow therapists, doctors and ... areas and learn more about the opportunities offered by ...
(Date:4/24/2015)... California (PRWEB) April 24, 2015 Ryadon ... a wide range of capabilities and services to complement ... , Ryadon's Quantity Discount Program will be offered on ... follows: , Order 4-19: Receive 10% discount - Order ... by Using the Drawer Slides Products, ...
(Date:4/24/2015)... York (PRWEB) April 24, 2015 ... move forward in the federal multidistrict litigation underway ... According to court documents, the parties involved in ... April 16th detailing, among other things, preparation for ... that counsel for both plaintiffs and defendants have ...
Breaking Medicine News(10 mins):Health News:Parker and Sons Plans to Expand in 2015 2Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 3Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3Health News:Federal Lipitor Lawsuits Progress, as New Status Report Details Preparation for Upcoming Bellwether Trials 2Health News:Federal Lipitor Lawsuits Progress, as New Status Report Details Preparation for Upcoming Bellwether Trials 3
... have an occasional "bad day" are at increased risk of ... ,It is not uncommon for people over age 70 to ... least half a day and/or cutting back on usual activities ... this is just a normal sign of aging and not ...
... women with endometriosis may one day lead to new ... new research suggests. What's more, the researchers may have ... unfortunate consequence of the condition. ,Anywhere from 10 to ... occurs when the tissue //that lines the uterus, the ...
... biopsy will tell you it’s not a pleasant experience. Now ... for prostate cancer and eliminate the need for unnecessary biopsies ... his prostate after blood tests revealed elevated levels of PSA ... prostate cancer. "Every time they take a section through the ...
... The first major conference on the deadly SARS epidemic ... today. More than 1,000 scientists and clinicians gathered to ... scientific findings and talk about control strategies for a ... infected 8,460. ,The meeting in Kuala Lumpur will also ...
... including non-smokers, are misusing nicotine patches and gum. The authors ... up for health trouble if they smoke and use the ... use the products to maintain their nicotine levels. ,But an ... have lied on the survey. And even if they weren't, ...
... study shows young children with high cholesterol levels are ... and adulthood. Researchers studied the eating habits and cholesterol ... years. The children were examined by doctors and had ... cholesterol, measured periodically. ,Results of the study show children ...
Cached Medicine News:Health News:Teens Misusing Nicotine-Replacement Products 2
(Date:4/24/2015)... , April 24, 2015  Elekta has CE ... Monaco® treatment planning system , enabling European clinics to ... major treatment techniques including advanced 3D planning, IMRT, VMAT ... Monaco ® ... well improved workflow efficiency. Advancements in 3D planning as ...
(Date:4/23/2015)... Calif., April 23, 2015  Edwards Lifesciences Corporation (NYSE: ... heart valves and hemodynamic monitoring, today reported net income ... or $1.12 per diluted share.  Net income for the ... $0.56 per diluted share, and non-GAAP net income was ... Net sales for the quarter ended March 31, 2015 increased ...
(Date:4/23/2015)... - Health Canada is working with the Canadian manufacturers ... information regarding the risk of serious cardiovascular side effects ... used at high doses (at or above 2400 mg/day). ... Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) ... inflammation. The majority of ibuprofen products in ...
Breaking Medicine Technology:Elekta CE marks for Monaco v5.10 treatment planning system 2Edwards Lifesciences Reports First Quarter Results 2Edwards Lifesciences Reports First Quarter Results 3Edwards Lifesciences Reports First Quarter Results 4Edwards Lifesciences Reports First Quarter Results 5Edwards Lifesciences Reports First Quarter Results 6Edwards Lifesciences Reports First Quarter Results 7Edwards Lifesciences Reports First Quarter Results 8Edwards Lifesciences Reports First Quarter Results 9Edwards Lifesciences Reports First Quarter Results 10Edwards Lifesciences Reports First Quarter Results 11Edwards Lifesciences Reports First Quarter Results 12Edwards Lifesciences Reports First Quarter Results 13Edwards Lifesciences Reports First Quarter Results 14Edwards Lifesciences Reports First Quarter Results 15Edwards Lifesciences Reports First Quarter Results 16Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 2Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 3Information Update - New safety information for prescription-strength ibuprofen: Risk of heart attack and stroke at high doses 4
... Corporation ("Futuremed") (TSX: FMD) and Cardinal Health Canada Inc. ... Inc. (NYSE: CAH ), announced today that ... morning regarding Cardinal Health Canada,s proposed acquisition of all ... for CAD $8.15 per Common Share in cash (the ...
... WORTH, Texas, February 16, 2012 Medical ... in Fort Worth, Texas on March 14-15, 2012. In ... and MD&M East (Philadelphia, PA), MD&M Texas Conference is ... device design and development presented by experienced medtech industry ...
Cached Medicine Technology:Cardinal Health Canada Inc. Receives Competition Bureau Clearance for Acquisition of Futuremed 2Cardinal Health Canada Inc. Receives Competition Bureau Clearance for Acquisition of Futuremed 3Cardinal Health Canada Inc. Receives Competition Bureau Clearance for Acquisition of Futuremed 4Medical Design & Manufacturing Conference to be Launched in Texas in March 2012 2
... Inverness Medical Professional Diagnostics is a ... extensive IFA and DFA test menu that ... and STDs as well as miscellaneous conjugates ... give you a wide assortment of substrates ...
... a leading provider of immunofluorescence assays, with ... that includes kits for autoimmune diseases, infectious ... conjugates and components. Our Impact IFA Test ... substrates and kit sizes to choose from. ...
... Diagnostics is a leading provider of immunofluorescence ... test menu that includes kits for autoimmune ... as miscellaneous conjugates and components. Our Impact ... assortment of substrates and kit sizes to ...
... Inverness Medical Professional Diagnostics is a ... extensive IFA and DFA test menu that ... and STDs as well as miscellaneous conjugates ... give you a wide assortment of substrates ...
Medicine Products: