Navigation Links
University of Colorado Cancer Center earns major grant to develop new bladder cancer drugs
Date:8/15/2012

Bladder cancer kills by metastasizing usually to the lungs. A major grant from the National Cancer Institute will help the University of Colorado Cancer Center develop new drugs aimed at stopping bladder cancer's spread, which will kill an estimated 15,000 people in the United States this year.

"Strong preliminary work shows specific proteins that bladder cancer cells need in order to leave the bladder and attach to lung tissue. And additional work points to a number of drug candidates that block the activity of these proteins. The current project aims to select the best drug, use medicinal chemistry to boost its effectiveness, and move the optimized drug toward a human clinical trial," says Dan Theodorescu, MD, PhD, director of the University of Colorado Cancer Center, who will co-lead the project with David Ross, PhD, chair of the Department of Pharmaceutical Sciences at the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of Colorado.

The work is especially important in light of two current conditions: first, the extended absence of new drugs targeting bladder cancer, with the most recent advance being the addition of the drug gemcitabine, which earned FDA approval in 1997; and second, the recent explosion of technologies that allow the development of drugs that target a cancer's specific genetic abnormalities.

"We've seen a paradigm shift toward targeted therapies drugs that unlike the traditional chemotherapies selectively kill cancer cells while leaving healthy tissue unharmed. We hope to apply this paradigm to metastatic bladder cancer," says Colin Dinney, MD, co-principal investigator and chair of the Department of Urology at project partner MD Anderson.

"This project will target metastatic colonization in bladder cancer by targeting the proteins that drive these processes," says David McConkey, PhD, co-principal investigator at MD Anderson.

"We also hope to define the biomarkers of patients likely to respond to the drugs," Theodorescu says. Defining the population most likely to benefit from the new drugs would allow the group to select these patients for Phase I clinical trials the project's intended endpoint.

"We are all hopeful that three years from now, we'll have a drug in clinical trials that prevents or delays the development of metastatic disease high-risk patients following treatment of the primary tumor," Theodorescu says.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Hospital of the University of Pennsylvania selected to lead US nurse-training initiative
2. University of Pennsylvania and Novartis form alliance to expand use of personalized T cell cancer therapy
3. Boston University researchers expand synthetic biologys toolkit
4. Canadians super-sizing Canadas Food Guide servings: York University study
5. Tel Aviv University researcher says plants can see, smell, feel, and taste
6. Tel Aviv University research links childhood obesity to cancer risk
7. Marshall University scientist awarded NIH grant for lung cancer research
8. University of Texas Medical Branch to study hospital readmission
9. Oxford University Press acquires joint ownership of Journal of Surgical Case Reports
10. Tannins in sorghum and benefits focus of university, USDA study
11. ASHA grant funds cutting-edge AIDS research at Tel Aviv University
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... May 2016 – Lips ... central to popular cosmetic improvement efforts. Record numbers of clients now ask about lip ... or pouty, says Kally Papantoniou, MD, of Advanced Dermatology P.C. , The ...
(Date:5/26/2016)... (PRWEB) , ... May 26, ... ... organization promoting quality-based imaging practices, is seeking nominations to serve on its ... diagnostic imaging. , “RadSite’s quality-benchmarking activities incorporate key process and ...
(Date:5/26/2016)... ... May 26, 2016 , ... In Madeira Beach Florida, a ... a single drawbridge, citizens formed an organization, Madeira Beach United, to oppose two development ... the small town center to a high rise urban environment. , According to the ...
(Date:5/26/2016)... ... 26, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star ... High blood pressure affects millions of people worldwide, and many patients use prescription ... heart disease, stroke, kidney disease, and hardening of the arteries. However, prescription medications ...
(Date:5/26/2016)... ... May 26, 2016 , ... With long-term experience ... President of Business Intelligence and Informatics, effective immediately. http://www.fluidedgeconsulting.com , As ... as a healthcare business and financial strategist for over 20 years. By ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016  Zymo Research ... for their new reference materials that help researchers ... sample collection to analyses. The rapid growth of ... for researchers to have standard methods to improve ... generated. Biases inherently exist at every step of ...
(Date:5/25/2016)... As illustrated by the Spring ... the numbers and momentum of cannabis in the US ... billions, more research and development push the sector forward. ... Legal Marijuana Markets Report  from from ArcView Market Research ... the increase in sector is attributed to adult use ...
(Date:5/25/2016)... , May 25, 2016 MedDay, a ... announces that an oral presentation entitled "High doses of biotin ... trial" will be given by Professor Ayman Tourbah , ... Congress of the European Academy of Neurology (EAN) in ... related disorders 3" will take place on Sunday, 29 May ...
Breaking Medicine Technology: