Navigation Links
University of Cincinnati team to track tumor DNA through bloodstream
Date:4/4/2011

CINCINNATIMedical scientists know this about glioblastoma multiforme: the malignant brain tumor is aggressive, it is elusive, and it appears in different permutations.

In a novel effort to unravel the multiple identities of glioblastoma, a team of University of Cincinnati (UC) researchers has begun sequencing individual glioblastoma genomes and tracking abnormalities through the bloodstream. They hope that by mapping the various DNA rearrangements of glioblastoma tumors they will be able to establish biomarkers that will help them track the cancer's progress and guide their efforts to treat patients more effectively. They also hope the biomarkers will help them identify targets for new, improved therapies for the future.

The effort involves researchers from the UC Neuroscience Institute's Brain Tumor Center and the UC Cancer Institute.

"Glioblastoma tumors show some similarities under the microscope," explains Olivier Rixe, MD, PhD, director of the UC Experimental Therapeutics Program in and a neuro-oncologist with UC Health and the UC Brain Tumor Center. "But when we go deeper and deeper, we see some significant differences, especially in the DNA and chromosomes. So there is no one single glioblastoma. Each tumor is different."

During the next few months, the team will use a $50,000 grant from the Mayfield Education and Research Fund to map the DNA of glioblastoma cancer cells taken from tumors that have been surgically removed from 10 study participants. The genome of each tumor can be sequenced for about $3,000.

Genome sequencing has been done previously for glioblastoma multiforme (GBM) by the National Institutes of Health (NIH). The Cincinnati study's innovation lies in its quest to identify genetic abnormalities in individual tumors and then follow those abnormalities through the bloodstream. Researchers at Johns Hopkins University have employed the technique for a limited number of patients diagnosed with
'/>"/>

Contact: Cindy Starr
cstarr@mayfieldclinic.com
513-558-3505
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. First for Emory -- Rare hand transplant surgery successfully performed at Emory University Hospital
2. University of Colorado team identifies new colon cancer marker
3. A safer, more effective morphine may be possible with Indiana University discovery
4. Boston University School of Medicine professor receives award for quality of care research
5. Queens University puts over 2,400 food scares under the microscope
6. US health care reforms should use model developed by Queens University professor
7. University of Michigan awarded $4.9 million to help reduce obesity in preschool children
8. Oxford Nanopore announces licence agreement with Harvard University for graphene DNA sequencing
9. University of Michigan Cardiovascular Center studies new treatment for high-risk aortic patients
10. University Hospitals Case Medical Center testing innovative heat therapy for premature ejaculation
11. University of South Florida researchers find blood-brain barrier damaged by disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... NY (PRWEB) September 22, 2014 Manhattan ... on the side of the hip , which could ... treatment in Manhattan. This treatment is now offered at New ... is also called trochanteric bursitis, occurs when the trochanteric ... fluid-filled sac in the hip, between the iliotibial band ...
(Date:9/22/2014)... Steven Reinberg HealthDay Reporter ... are urging that all children aged 6 months and older ... Academy of Pediatrics updated their influenza vaccine recommendations to advise ... vaccine to build immunity. The AAP also wants parents of ... the nasal spray vaccine instead of the flu shot if ...
(Date:9/22/2014)... to 40 percent of patients undergoing breast cancer surgery ... all the cancerous tissue in the initial operation. However, ... tested a tool they developed that will help surgeons ... decreasing the chances for repeat operations. ... September 22, 2014 in the Proceedings of the ...
(Date:9/22/2014)... today became a founding partner in the Global STEM ... promoting young talent in science, technology, engineering and math ... York Academy of Sciences (NYAS), Malaysian Prime Minister Najib ... Sept. 22. , With the goal of developing over ... by 2020, the initiative will create a host of ...
(Date:9/22/2014)... living in Canada have a higher rate of heart ... while people, McMaster researchers have found. , The ... Association Journal (CMAJ Open) and may be found ... ethnic groups in the country is the more than ... about three percent of the population. They include people ...
Breaking Medicine News(10 mins):Health News:DNR Clinic Offers Hip Bursitis Treatment in Manhattan 2Health News:DNR Clinic Offers Hip Bursitis Treatment in Manhattan 3Health News:Pediatricians Urge Flu Vaccine for All Kids 6 Months and Older 2Health News:Pediatricians Urge Flu Vaccine for All Kids 6 Months and Older 3Health News:The fine line between breast cancer and normal tissues 2Health News:Growing scientists: World's future jobs are rooted in STEM 2Health News:Growing scientists: World's future jobs are rooted in STEM 3Health News:Higher risk of heart disease for South Asians in Canada 2
... in need of blood or are you inclined in donating the ... way, the solution for it is just a few clicks away. ... amazingly useful venture in 2000. He works for Central Railway as ... venture too. ,If you're located in Kolkata and badly ...
... University immunologist and author of the study said that they have ... aim of the cure is to prevent the immune system before ... a window of time and the pancreatic cells can be rescued ... the disease. , The results were published in the ...
... of a suspected bird flu infection. After this incident ... shipments from out of town. ,The city ... for a final diagnosis of the case. Health authorities ... Her condition deteriorated quickly, and she died despite hospital ...
... the March of Dimes has shown that U.S pregnancy ... of 40 weeks//, which is a week shorter than ... the pregnancy term period is attributed to better capabilities ... assisted deliveries. As a result there are fewer stillbirths, ...
... Medical Center have found that teenagers who have used herbal ... and 15 times more likely to have // abused anabolic ... ,"The study points to the need for ... using herbal remedies and from there probe deeper for possible ...
... in China has revealed that just over 67 per cent ... ,This survey was conducted recently by a research institute at ... respondents in 24 colleges of 19 cities.,The results said that ... how HIV/AIDS is transmitted and 75.6 per cent know how ...
Cached Medicine News:Health News:New Network To Ease Blood donation In India 2Health News:Type 1 diabetes has a cure? 2Health News:Using Herbal Products Heightens Substance Abuse Risk in Teens 2
(Date:9/22/2014)... DUBLIN , Sept. 22, 2014 ... the "PCSK9 and Other Novel Hypercholesterolemia Drugs" ... indicate that there is a high cholesterol burden despite ... Out of all the available options, statins have been ... concluded that reduction of plasma LDL cholesterol (LDLC) is ...
(Date:9/22/2014)... 2014  Aethlon Medical, Inc. (OTCQB: AEMD), the ... infectious disease, cancer and other life-threatening conditions, disclosed ... (DARPA) has informed the Company that it plans ... four of a five-year $5.9 million contract that ... under DARPA,s Dialysis-Like Therapeutics (DLT) program. ...
(Date:9/22/2014)... , Sept. 22, 2014 /PRNewswire/-- CANTEL MEDICAL CORP. (NYSE: ... and fiscal 2014 ended July 31, 2014 on Monday, September ... to discuss the results at 11:00 AM ET. Participating in ... Andrew A. Krakauer , President and CEO; Jorgen ... A. Sheldon , Senior Vice President, CFO and Treasurer; and ...
Breaking Medicine Technology:PCSK9 and Other Novel Hypercholesterolemia Drugs 2PCSK9 and Other Novel Hypercholesterolemia Drugs 3Aethlon Medical Receives Notice of DARPA Contract Renewal 2Aethlon Medical Receives Notice of DARPA Contract Renewal 3Aethlon Medical Receives Notice of DARPA Contract Renewal 4Cantel Medical Corp. To Hold Conference Call To Discuss Results For Its Fourth Quarter And Fiscal 2014 Ended July 31, 2014 2
... N.J., Oct. 15 Watson Pharmaceuticals, Inc. (NYSE: ... Laboratories, Inc., has received approval from the United States ... Application (ANDA) for Amlodipine Besylate/Benazepril 5/20mg, 10/20mg, 2.5/10mg, and ... The ANDA was acquired as part of Watson,s acquisition ...
... Inc. (Nasdaq: REGN ) will webcast its ... Industry Conference on Friday, October 22, 2010.  The presentation ... may be accessed through the Company,s web site, ... version of the presentation will be available after the ...
Cached Medicine Technology:Watson's Generic Version of Lotrel ® Receives FDA Approval 2
... new thinking to address common problems associated ... mm diameter outer arthroscope sheath, the shorter, ... Videoscope has superior access and mobility in ... and especially in the elbow and ankle. ...
... is the second generation of the lens ... technology allows one-handed delivery of the C11UB ... colored plunger allows better visualization and is ... insertion. The modified 55-degree beveled tip eases ...
... Heart 2006 is a long-term Transtelephonic ... This device is the solution ... symptoms and their correlation to the ... it provides 2 lead loop recording ...
... cable and 4 metal chest electrodes ... 3-step procedure enabling a patient to ... lead ECG through a simple change ... seconds per lead and 10 seconds ...
Medicine Products: