CINCINNATIResearchers from the University of Cincinnati (UC) have received a four-year, $3.7 million grant from the U.S. Department of Defense for investigations into circadian rhythms that could lead to enhanced understanding of disease treatments, trauma care and human combat performance.
The research will be conducted by an interdisciplinary team led by Christian Hong, PhD, an assistant professor in the department of molecular and cellular physiology. The team includes Sookkyung Lim, PhD, an assistant professor in UC's mathematical sciences department, Seongho Song, PhD, an associate professor of mathematical sciences, and Sean Moore, MD, an assistant professor of pediatrics who conducts research at Cincinnati Children's Hospital Medical Center.
The grant is from the Defense Advanced Research Projects Agency (DARPA), an agency of the Department of Defense. Founded in 1958 as a response to the Soviet Union's launch of Sputnik, DARPA's mission is to prevent and create strategic surprise.
"So many things cycle on a schedulefor instance, we anticipate getting up in the morning because there is an internal clock that communicates with other molecular mechanisms resulting in changes," says Hong. "Our body temperature, feeding rhythms, rate of metabolism, hormonal balanceseverything has a schedule, and the Department of Defense is interested in understanding these schedules at the molecular level.
"Soldiers are constantly moving around and facing interruptions in their circadian rhythms, such as sleep deprivation. Also, when soldiers get hurt, it's important to understand the best time and target to treat themthe fastest solution at the given moment. So if the Department of Defense has a map of the temporal information, it could apply the appropriate regimen more readily."
Research goals are twofold, according to Hong: First, to investigate temporal information of four distinct yet interconnected cellular processes (cir
|Contact: Keith Herrell|
University of Cincinnati Academic Health Center