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University of Arizona researchers seek safer cystic fibrosis test
Date:9/10/2009

he tube. This fluid then can be analyzed for a variety of factors.

Bronchoalveolar lavage is invasive and carries some risk. The aim of Dr. Snyder's study is to develop a safer, non-invasive procedure that can measure some of the data that can be taken with a bronchoalveolar lavage with comparable accuracy.

The non-invasive procedure that Dr. Snyder's research will explore involves measuring signs of lung dryness by using a patient's breath that is condensed in a cooling chamber. To do this, the team first will have a patient breathe into a machine in Dr. Snyder's laboratory in the College of Pharmacy. Breathing on this machine condenses the patient's breath in a cooling chamber so that the research team can measure the amount of sodium, potassium and chloride it contains. Immediately after this non-invasive test, the patient will go to University Medical Center for a bronchoalveolar lavage performed under the direction of Drs. Daines and Morgan.

Once the brochoalveolar lavage is completed, the team will compare the amount of sodium, potassium, and chloride ions gathered in that test to the amount gathered non-invasively in the breath test. This will allow the team to see if the non-invasive test is as accurate as the invasive technique.

"This research will provide data to further explore the development of a non-invasive tool to measure airway fluid composition," says Dr. Snyder. "It will provide important preliminary data for future, larger studies in this patient population. Our goal is to invent a non-invasive test that will aid in the assessment and treatment of cystic fibrosis."


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Contact: Karin Lorentzen
lorentzen@pharmacy.arizona.edu
520-626-3725
University of Arizona, College of Pharmacy
Source:Eurekalert  

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